The American Society for Clinical Investigation
@the-asci.org
The ASCI is a nonprofit honor society of physician-scientists. Founded in 1908, the Society is home to 3,500+ members across academic medicine and industry.
https://the-asci.org
Take action for federal funding of research:
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https://the-asci.org
Take action for federal funding of research:
https://www.fundresearch.org/
A promising therapeutic approach for glioblastoma
ASCI member Markus D. Siegelin & team detail a strategy targeting CDK12 in mouse models that prolongs survival and eliminates tumors in combination with standard treatment.
insight.jci.org/articles/vie...
ASCI member Markus D. Siegelin & team detail a strategy targeting CDK12 in mouse models that prolongs survival and eliminates tumors in combination with standard treatment.
insight.jci.org/articles/vie...
November 14, 2025 at 5:05 PM
A promising therapeutic approach for glioblastoma
ASCI member Markus D. Siegelin & team detail a strategy targeting CDK12 in mouse models that prolongs survival and eliminates tumors in combination with standard treatment.
insight.jci.org/articles/vie...
ASCI member Markus D. Siegelin & team detail a strategy targeting CDK12 in mouse models that prolongs survival and eliminates tumors in combination with standard treatment.
insight.jci.org/articles/vie...
New insights into lipid redistribution!
ASCI member Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease.
www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
ASCI member Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease.
www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
November 14, 2025 at 12:16 AM
New insights into lipid redistribution!
ASCI member Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease.
www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
ASCI member Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease.
www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
A Research Letter by ASCI member Joshua T. Schiffer & team:
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
November 13, 2025 at 8:30 PM
A Research Letter by ASCI member Joshua T. Schiffer & team:
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
Excessive aldosterone production can lead to cardiovascular problems, but therapeutic limitations remain
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
November 13, 2025 at 5:08 PM
Excessive aldosterone production can lead to cardiovascular problems, but therapeutic limitations remain
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome
ASCI member Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms.
www.jci.org/articles/vie...
ASCI member Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms.
www.jci.org/articles/vie...
November 12, 2025 at 5:05 PM
Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome
ASCI member Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms.
www.jci.org/articles/vie...
ASCI member Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms.
www.jci.org/articles/vie...
Spinal & bulbar muscular atrophy is a degenerative disorder of the neuromuscular system with no cure
ASCI member Andrew P. Lieberman & team find AR-targeted ASOs rescue disease in SBMA mice, showing unanticipated benefits on the spinal cord transcriptional landscape: 10.1172/JCI182955
ASCI member Andrew P. Lieberman & team find AR-targeted ASOs rescue disease in SBMA mice, showing unanticipated benefits on the spinal cord transcriptional landscape: 10.1172/JCI182955
November 11, 2025 at 5:05 PM
Spinal & bulbar muscular atrophy is a degenerative disorder of the neuromuscular system with no cure
ASCI member Andrew P. Lieberman & team find AR-targeted ASOs rescue disease in SBMA mice, showing unanticipated benefits on the spinal cord transcriptional landscape: 10.1172/JCI182955
ASCI member Andrew P. Lieberman & team find AR-targeted ASOs rescue disease in SBMA mice, showing unanticipated benefits on the spinal cord transcriptional landscape: 10.1172/JCI182955
Osteoarthritis is the most common joint disease, but there are no approved disease-modifying treatments
ASCI member Martin K. Lotz & team discover histamine H1 receptor inverse agonists improve structure & pain in osteoarthritis mice: www.jci.org/articles/vie...
ASCI member Martin K. Lotz & team discover histamine H1 receptor inverse agonists improve structure & pain in osteoarthritis mice: www.jci.org/articles/vie...
November 10, 2025 at 5:07 PM
Osteoarthritis is the most common joint disease, but there are no approved disease-modifying treatments
ASCI member Martin K. Lotz & team discover histamine H1 receptor inverse agonists improve structure & pain in osteoarthritis mice: www.jci.org/articles/vie...
ASCI member Martin K. Lotz & team discover histamine H1 receptor inverse agonists improve structure & pain in osteoarthritis mice: www.jci.org/articles/vie...
Reposted by The American Society for Clinical Investigation
Alveolar macrophage-fibroblast crosstalk includes a feedforward arginase 1/IL-6 circuit implicated in pulmonary fibrosis: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
November 7, 2025 at 7:30 PM
Alveolar macrophage-fibroblast crosstalk includes a feedforward arginase 1/IL-6 circuit implicated in pulmonary fibrosis: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
Reposted by The American Society for Clinical Investigation
Commentary: Neutrophils take center stage in VEXAS syndrome pathogenesis
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
November 7, 2025 at 2:03 PM
Commentary: Neutrophils take center stage in VEXAS syndrome pathogenesis
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
Overcoming resistance to immune checkpoint inhibitors remains a major objective in cancer
Here, ASCI member Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Here, ASCI member Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
November 6, 2025 at 5:07 PM
Overcoming resistance to immune checkpoint inhibitors remains a major objective in cancer
Here, ASCI member Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Here, ASCI member Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Reposted by The American Society for Clinical Investigation
What's basic research? The "useless" science that changes everything.
Federal funding helps researchers take the long view that companies can't. That's how breakthrough treatments are born.
#SaveOurCures #FundNIH
Federal funding helps researchers take the long view that companies can't. That's how breakthrough treatments are born.
#SaveOurCures #FundNIH
November 3, 2025 at 6:07 PM
What's basic research? The "useless" science that changes everything.
Federal funding helps researchers take the long view that companies can't. That's how breakthrough treatments are born.
#SaveOurCures #FundNIH
Federal funding helps researchers take the long view that companies can't. That's how breakthrough treatments are born.
#SaveOurCures #FundNIH
New research by ASCI member Marc E. Rothenberg 👇
Rothenberg & team discover allergen-specific mRNA-lipid nanoparticle therapy modulates immune responses, reducing allergy symptoms while enhancing protection in mice: www.jci.org/articles/vie...
@jilianmelamed.bsky.social @drewweissmanlab.bsky.social @cincykidsallergyim.bsky.social
@jilianmelamed.bsky.social @drewweissmanlab.bsky.social @cincykidsallergyim.bsky.social
November 4, 2025 at 4:45 PM
New research by ASCI member Marc E. Rothenberg 👇
Out now by ASCI member Daniel Drucker @danieljdrucker.bsky.social
Anti-inflammatory actions of glucagon-like peptide 1 medicines beyond metabolic benefits
Chi Kin Wong & Daniel J. Drucker provide a Review for JCI’s Series on Clinical Innovation and Scientific Progress in GLP-1 Medicine: www.jci.org/articles/vie...
Chi Kin Wong & Daniel J. Drucker provide a Review for JCI’s Series on Clinical Innovation and Scientific Progress in GLP-1 Medicine: www.jci.org/articles/vie...
November 3, 2025 at 8:40 PM
Out now by ASCI member Daniel Drucker @danieljdrucker.bsky.social
Reposted by The American Society for Clinical Investigation
This paper made it to the top of our readership list:
SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress: www.jci.org/articles/vie...
SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress: www.jci.org/articles/vie...
November 1, 2025 at 1:01 PM
This paper made it to the top of our readership list:
SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress: www.jci.org/articles/vie...
SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress: www.jci.org/articles/vie...
A stretch for gut cells extends our understanding in #BowelDisease
ASCI member Robert O. Heuckeroth & team subjected human intestinal smooth muscle cells to pathological stretch, revealing gene-expression changes and a proinflammatory phenotype: insight.jci.org/articles/vie...
ASCI member Robert O. Heuckeroth & team subjected human intestinal smooth muscle cells to pathological stretch, revealing gene-expression changes and a proinflammatory phenotype: insight.jci.org/articles/vie...
October 30, 2025 at 5:38 PM
A stretch for gut cells extends our understanding in #BowelDisease
ASCI member Robert O. Heuckeroth & team subjected human intestinal smooth muscle cells to pathological stretch, revealing gene-expression changes and a proinflammatory phenotype: insight.jci.org/articles/vie...
ASCI member Robert O. Heuckeroth & team subjected human intestinal smooth muscle cells to pathological stretch, revealing gene-expression changes and a proinflammatory phenotype: insight.jci.org/articles/vie...
Little progress has been made in treatment of anaplastic thyroid cancer
ASCI member James A. Fagin & team now find mice with aggressive ATC respond to inhibitor combination dabrafenib/trametinib by affecting cancer cell MHCII expression & increasing T-cell infiltration: www.jci.org/articles/vie...
ASCI member James A. Fagin & team now find mice with aggressive ATC respond to inhibitor combination dabrafenib/trametinib by affecting cancer cell MHCII expression & increasing T-cell infiltration: www.jci.org/articles/vie...
October 30, 2025 at 4:06 PM
Little progress has been made in treatment of anaplastic thyroid cancer
ASCI member James A. Fagin & team now find mice with aggressive ATC respond to inhibitor combination dabrafenib/trametinib by affecting cancer cell MHCII expression & increasing T-cell infiltration: www.jci.org/articles/vie...
ASCI member James A. Fagin & team now find mice with aggressive ATC respond to inhibitor combination dabrafenib/trametinib by affecting cancer cell MHCII expression & increasing T-cell infiltration: www.jci.org/articles/vie...
Reposted by The American Society for Clinical Investigation
Today's research assistants, tomorrow's cure-finders:
Federal funding helps train the next generation of biomedical scientists. By investing in researchers today means investing in decades of future discoveries.
Speak up: http://fundresearch.org
#SaveOurCures #ScienceEducation #FutureReady
Federal funding helps train the next generation of biomedical scientists. By investing in researchers today means investing in decades of future discoveries.
Speak up: http://fundresearch.org
#SaveOurCures #ScienceEducation #FutureReady
October 29, 2025 at 4:04 PM
Today's research assistants, tomorrow's cure-finders:
Federal funding helps train the next generation of biomedical scientists. By investing in researchers today means investing in decades of future discoveries.
Speak up: http://fundresearch.org
#SaveOurCures #ScienceEducation #FutureReady
Federal funding helps train the next generation of biomedical scientists. By investing in researchers today means investing in decades of future discoveries.
Speak up: http://fundresearch.org
#SaveOurCures #ScienceEducation #FutureReady
A new paradigm for ion channel regulation!
ASCI member @geoffrey-pitt.bsky.social & team reveal FGF13 regulates cardiac sodium channels (no binding required) by affecting membrane cholesterol.
www.jci.org/articles/vie...
ASCI member @geoffrey-pitt.bsky.social & team reveal FGF13 regulates cardiac sodium channels (no binding required) by affecting membrane cholesterol.
www.jci.org/articles/vie...
October 29, 2025 at 4:09 PM
A new paradigm for ion channel regulation!
ASCI member @geoffrey-pitt.bsky.social & team reveal FGF13 regulates cardiac sodium channels (no binding required) by affecting membrane cholesterol.
www.jci.org/articles/vie...
ASCI member @geoffrey-pitt.bsky.social & team reveal FGF13 regulates cardiac sodium channels (no binding required) by affecting membrane cholesterol.
www.jci.org/articles/vie...
Reposted by The American Society for Clinical Investigation
Imagine running the same experiment 1,000 times. 999 might fail.
Imagine dedicating your career to a problem that might not be solved in your lifetime.
That's a biomedical researcher. 💙
They keep going because somewhere, a family is waiting for hope.
#SaveOurCures
Imagine dedicating your career to a problem that might not be solved in your lifetime.
That's a biomedical researcher. 💙
They keep going because somewhere, a family is waiting for hope.
#SaveOurCures
October 28, 2025 at 4:12 PM
Imagine running the same experiment 1,000 times. 999 might fail.
Imagine dedicating your career to a problem that might not be solved in your lifetime.
That's a biomedical researcher. 💙
They keep going because somewhere, a family is waiting for hope.
#SaveOurCures
Imagine dedicating your career to a problem that might not be solved in your lifetime.
That's a biomedical researcher. 💙
They keep going because somewhere, a family is waiting for hope.
#SaveOurCures
A healing holdup for skin infections
ASCI member Richard L. Gallo & team find Staphylococcus aureus inhibits the expression of lipid synthesis genes in skin cells, delaying wound healing and impairing barrier formation: www.jci.org/articles/vie...
ASCI member Richard L. Gallo & team find Staphylococcus aureus inhibits the expression of lipid synthesis genes in skin cells, delaying wound healing and impairing barrier formation: www.jci.org/articles/vie...
October 28, 2025 at 4:09 PM
A healing holdup for skin infections
ASCI member Richard L. Gallo & team find Staphylococcus aureus inhibits the expression of lipid synthesis genes in skin cells, delaying wound healing and impairing barrier formation: www.jci.org/articles/vie...
ASCI member Richard L. Gallo & team find Staphylococcus aureus inhibits the expression of lipid synthesis genes in skin cells, delaying wound healing and impairing barrier formation: www.jci.org/articles/vie...
Protection against the fungus among us after mold spore inhalation…
ASCI member @fungalspore.bsky.social investigate Aspergillus fumigatus infection in mice, revealing communication between plasmacytoid DCs & neutrophils in the lung is necessary for antifungal activity: www.jci.org/articles/vie...
ASCI member @fungalspore.bsky.social investigate Aspergillus fumigatus infection in mice, revealing communication between plasmacytoid DCs & neutrophils in the lung is necessary for antifungal activity: www.jci.org/articles/vie...
October 27, 2025 at 4:08 PM
Protection against the fungus among us after mold spore inhalation…
ASCI member @fungalspore.bsky.social investigate Aspergillus fumigatus infection in mice, revealing communication between plasmacytoid DCs & neutrophils in the lung is necessary for antifungal activity: www.jci.org/articles/vie...
ASCI member @fungalspore.bsky.social investigate Aspergillus fumigatus infection in mice, revealing communication between plasmacytoid DCs & neutrophils in the lung is necessary for antifungal activity: www.jci.org/articles/vie...
Join us for ASCI Scientific Session on November 10th:
Brian K. Kobilka discusses his career as a physician-scientist with mentor and Nobel co-laureate (2012) Robert J. Lefkowitz
Register: buff.ly/PnkJgtQ
Brian K. Kobilka discusses his career as a physician-scientist with mentor and Nobel co-laureate (2012) Robert J. Lefkowitz
Register: buff.ly/PnkJgtQ
October 24, 2025 at 5:38 PM
Join us for ASCI Scientific Session on November 10th:
Brian K. Kobilka discusses his career as a physician-scientist with mentor and Nobel co-laureate (2012) Robert J. Lefkowitz
Register: buff.ly/PnkJgtQ
Brian K. Kobilka discusses his career as a physician-scientist with mentor and Nobel co-laureate (2012) Robert J. Lefkowitz
Register: buff.ly/PnkJgtQ
Stress, plasticity, and fibrosis: unfolding the role of the IRE1α/RIDD/Fgfr2 axis: www.jci.org/articles/vie...
YPSA awardee SeungHye Han comments on Vincent C. Auyeung et al. (www.jci.org/articles/vie...)
YPSA awardee SeungHye Han comments on Vincent C. Auyeung et al. (www.jci.org/articles/vie...)
October 24, 2025 at 4:09 PM
Stress, plasticity, and fibrosis: unfolding the role of the IRE1α/RIDD/Fgfr2 axis: www.jci.org/articles/vie...
YPSA awardee SeungHye Han comments on Vincent C. Auyeung et al. (www.jci.org/articles/vie...)
YPSA awardee SeungHye Han comments on Vincent C. Auyeung et al. (www.jci.org/articles/vie...)
DNA damage provides a bright spot in rhabdoid & epithelioid sarcomas
ASCI member Mark Kentis @kentsisresearch.bsky.social show combined EZH2/ATR inhibition improves response in SMARCB1-deficient tumor models via epigenetic induction of transposase-derived PGBD5: www.jci.org/articles/vie...
ASCI member Mark Kentis @kentsisresearch.bsky.social show combined EZH2/ATR inhibition improves response in SMARCB1-deficient tumor models via epigenetic induction of transposase-derived PGBD5: www.jci.org/articles/vie...
October 23, 2025 at 4:08 PM
DNA damage provides a bright spot in rhabdoid & epithelioid sarcomas
ASCI member Mark Kentis @kentsisresearch.bsky.social show combined EZH2/ATR inhibition improves response in SMARCB1-deficient tumor models via epigenetic induction of transposase-derived PGBD5: www.jci.org/articles/vie...
ASCI member Mark Kentis @kentsisresearch.bsky.social show combined EZH2/ATR inhibition improves response in SMARCB1-deficient tumor models via epigenetic induction of transposase-derived PGBD5: www.jci.org/articles/vie...
How hypertension promotes bone loss…
ASCI member David G. Harrison & team comprehensively characterize the effect of hypertension on bone properties, finding inflammatory activation and IL-17A-producing T cells as targetable mediators in hypertension-related bone loss: www.jci.org/articles/vie...
ASCI member David G. Harrison & team comprehensively characterize the effect of hypertension on bone properties, finding inflammatory activation and IL-17A-producing T cells as targetable mediators in hypertension-related bone loss: www.jci.org/articles/vie...
October 22, 2025 at 5:38 PM
How hypertension promotes bone loss…
ASCI member David G. Harrison & team comprehensively characterize the effect of hypertension on bone properties, finding inflammatory activation and IL-17A-producing T cells as targetable mediators in hypertension-related bone loss: www.jci.org/articles/vie...
ASCI member David G. Harrison & team comprehensively characterize the effect of hypertension on bone properties, finding inflammatory activation and IL-17A-producing T cells as targetable mediators in hypertension-related bone loss: www.jci.org/articles/vie...