The American Society for Clinical Investigation
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the-asci.org
The American Society for Clinical Investigation
@the-asci.org
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The ASCI is a nonprofit honor society of physician-scientists. Founded in 1908, the Society is home to 3,500+ members across academic medicine and industry.

https://the-asci.org

Take action for federal funding of research:

https://www.fundresearch.org/
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the-asci.org
A promising therapeutic approach for glioblastoma

ASCI member Markus D. Siegelin & team detail a strategy targeting CDK12 in mouse models that prolongs survival and eliminates tumors in combination with standard treatment.

insight.jci.org/articles/vie...
November 14, 2025 at 5:05 PM
the-asci.org
New insights into lipid redistribution!

ASCI member Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease.

www.jci.org/articles/vie...

The figure shows MASH liver has elevated S100A8+ macrophages.
November 14, 2025 at 12:16 AM
the-asci.org
A Research Letter by ASCI member Joshua T. Schiffer & team:

Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
November 13, 2025 at 8:30 PM
the-asci.org
Excessive aldosterone production can lead to cardiovascular problems, but therapeutic limitations remain

ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
November 13, 2025 at 5:08 PM
the-asci.org
Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome

ASCI member Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms.

www.jci.org/articles/vie...
November 12, 2025 at 5:05 PM
the-asci.org
Spinal & bulbar muscular atrophy is a degenerative disorder of the neuromuscular system with no cure

ASCI member Andrew P. Lieberman & team find AR-targeted ASOs rescue disease in SBMA mice, showing unanticipated benefits on the spinal cord transcriptional landscape: 10.1172/JCI182955
November 11, 2025 at 5:05 PM
the-asci.org
Osteoarthritis is the most common joint disease, but there are no approved disease-modifying treatments

ASCI member Martin K. Lotz & team discover histamine H1 receptor inverse agonists improve structure & pain in osteoarthritis mice: www.jci.org/articles/vie...
November 10, 2025 at 5:07 PM
the-asci.org
Overcoming resistance to immune checkpoint inhibitors remains a major objective in cancer

Here, ASCI member Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
November 6, 2025 at 5:07 PM
the-asci.org
A stretch for gut cells extends our understanding in #BowelDisease

ASCI member Robert O. Heuckeroth & team subjected human intestinal smooth muscle cells to pathological stretch, revealing gene-expression changes and a proinflammatory phenotype: insight.jci.org/articles/vie...
October 30, 2025 at 5:38 PM
the-asci.org
Little progress has been made in treatment of anaplastic thyroid cancer

ASCI member James A. Fagin & team now find mice with aggressive ATC respond to inhibitor combination dabrafenib/trametinib by affecting cancer cell MHCII expression & increasing T-cell infiltration: www.jci.org/articles/vie...
October 30, 2025 at 4:06 PM
the-asci.org
A new paradigm for ion channel regulation!

ASCI member @geoffrey-pitt.bsky.social & team reveal FGF13 regulates cardiac sodium channels (no binding required) by affecting membrane cholesterol.

www.jci.org/articles/vie...
October 29, 2025 at 4:09 PM
the-asci.org
A healing holdup for skin infections

ASCI member Richard L. Gallo & team find Staphylococcus aureus inhibits the expression of lipid synthesis genes in skin cells, delaying wound healing and impairing barrier formation: www.jci.org/articles/vie...
October 28, 2025 at 4:09 PM
the-asci.org
Protection against the fungus among us after mold spore inhalation…

ASCI member @fungalspore.bsky.social investigate Aspergillus fumigatus infection in mice, revealing communication between plasmacytoid DCs & neutrophils in the lung is necessary for antifungal activity: www.jci.org/articles/vie...
October 27, 2025 at 4:08 PM
the-asci.org
Join us for ASCI Scientific Session on November 10th:

Brian K. Kobilka discusses his career as a physician-scientist with mentor and Nobel co-laureate (2012) Robert J. Lefkowitz

Register: buff.ly/PnkJgtQ
October 24, 2025 at 5:38 PM
the-asci.org
Stress, plasticity, and fibrosis: unfolding the role of the IRE1α/RIDD/Fgfr2 axis: www.jci.org/articles/vie...

YPSA awardee SeungHye Han comments on Vincent C. Auyeung et al. (www.jci.org/articles/vie...)
October 24, 2025 at 4:09 PM
the-asci.org
DNA damage provides a bright spot in rhabdoid & epithelioid sarcomas

ASCI member Mark Kentis @kentsisresearch.bsky.social show combined EZH2/ATR inhibition improves response in SMARCB1-deficient tumor models via epigenetic induction of transposase-derived PGBD5: www.jci.org/articles/vie...
October 23, 2025 at 4:08 PM
the-asci.org
How hypertension promotes bone loss…

ASCI member David G. Harrison & team comprehensively characterize the effect of hypertension on bone properties, finding inflammatory activation and IL-17A-producing T cells as targetable mediators in hypertension-related bone loss: www.jci.org/articles/vie...
October 22, 2025 at 5:38 PM
the-asci.org
This issue’s Cover features work by ASCI member Ankit Bharat & team on an integrative single-cell transcriptomic analysis of fibrosis-associated lung diseases, revealing signatures in CLAD.

insight.jci.org/articles/vie...
October 22, 2025 at 4:09 PM
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Can we treat pulmonary fibrosis by getting rid of RIDD activity?

ASCI member Feroz R. Papa & team find pharmacologic inhibition of IRE1α-dependent decay (RIDD) protects alveolar epithelial identity and prevents #PulmonaryFibrosis in mice: www.jci.org/articles/vie...
October 21, 2025 at 4:08 PM
the-asci.org
In Sweet syndrome, skin cells keep immune cells alive longer, worsening inflammation.

ASCI member Thomas H. Leung & team identify long-lived neutrophils that can be blocked, offering comparable efficacy to high-dose corticosteroids in coculture assays: www.jci.org/articles/vie...
October 20, 2025 at 4:40 PM
the-asci.org
Synaptic transmission promotes brain metastatic outgrowth in breast cancer

In this Research Letter, ASCI member Jason T. Huse & team use isogenic cell lines, mouse models, and human tissue and show GABA receptor antagonists impair brain metastasis in mice.

insight.jci.org/articles/vie...
October 17, 2025 at 4:09 PM
the-asci.org
Foundational work for angiogenesis strategies!

ASCI member Mark W. Feinberg & team report on a new lncRNA-miRNA signaling pathway with implications for the treatment of peripheral artery disease: www.jci.org/articles/vie...
October 16, 2025 at 5:38 PM
the-asci.org
Talc used in pleurodesis prevents pleural fluid/air reaccumulation by inducing inflammation & scarring

ASCI member Francis X. McCormack & team report an alternative—hydroxyapatite microspheres induce durable pleurodesis with rapid clearance in mice: insight.jci.org/articles/vie...
October 16, 2025 at 4:09 PM
the-asci.org
ASCI member Warren Shlomchik & team find donor-derived progenitor-like CD8 T cells expressing TCF-1 develop early post-transplant & sustain pathogenic T cell responses in GVHD tissues: insight.jci.org/articles/vie...
October 15, 2025 at 5:38 PM
the-asci.org
IL-17 antagonism as a treatment option for calciphylaxis?

ASCI member Arjun Deb & team report on the attenuation of calcific deposits in rat models of this rare, life-threatening disorder by pharmacological targeting of the IL17/neutrophil axis: www.jci.org/articles/vie...
October 15, 2025 at 4:09 PM