We report that a physiologically relevant small-molecule metabolite decouples functional phase separation from age-dependent fibrillization via a distinct mechanism of action, thereby preserving the biochemical activity of Tau condensates.

In our new preprint, we study the physical aging of biochemically active condensates of an engineered Tau protein into disease-linked fibrils — and investigate whether small molecules can counteract this transition.
@priya-r-banerjee.bsky.social
biorxiv.org/content/10.1101/2025.03.18.643977v1
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