Tharun Selvam Mahendran
@tharun-mahendran.bsky.social
Pinned
In our new preprint, we study the physical aging of biochemically active condensates of an engineered Tau protein into disease-linked fibrils — and investigate whether small molecules can counteract this transition.
@priya-r-banerjee.bsky.social
biorxiv.org/content/10.1101/2025.03.18.643977v1
🧵1/3
@priya-r-banerjee.bsky.social
biorxiv.org/content/10.1101/2025.03.18.643977v1
🧵1/3
In our new preprint, we study the physical aging of biochemically active condensates of an engineered Tau protein into disease-linked fibrils — and investigate whether small molecules can counteract this transition.
@priya-r-banerjee.bsky.social
biorxiv.org/content/10.1101/2025.03.18.643977v1
🧵1/3
@priya-r-banerjee.bsky.social
biorxiv.org/content/10.1101/2025.03.18.643977v1
🧵1/3
April 2, 2025 at 4:17 AM
In our new preprint, we study the physical aging of biochemically active condensates of an engineered Tau protein into disease-linked fibrils — and investigate whether small molecules can counteract this transition.
@priya-r-banerjee.bsky.social
biorxiv.org/content/10.1101/2025.03.18.643977v1
🧵1/3
@priya-r-banerjee.bsky.social
biorxiv.org/content/10.1101/2025.03.18.643977v1
🧵1/3
Reposted by Tharun Selvam Mahendran
Decoupling Phase Separation and Fibrillization Preserves Activity of Biomolecular Condensates https://www.biorxiv.org/content/10.1101/2025.03.18.643977v1
March 19, 2025 at 6:48 PM
Decoupling Phase Separation and Fibrillization Preserves Activity of Biomolecular Condensates https://www.biorxiv.org/content/10.1101/2025.03.18.643977v1