Tomás Di Domenico
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tdido.eu
Tomás Di Domenico
@tdido.eu
44 followers 100 following 9 posts
Bioinformatics and Scientific Computing at @bioinformatics.cnio.es, @cniostopcancer.bsky.social
Posts Replies Media Videos
Reposted by Tomás Di Domenico
bioinformatics.cnio.es
#PorLaCiencia que hacemos en
@cniostopcancer.bsky.social.
November 26, 2025 at 9:25 AM
Reposted by Tomás Di Domenico
bioinformatics.cnio.es
📣 We are hiring a Postdoc in @bioinformatics.cnio.es at @cniostopcancer.bsky.social!

🔬 Cancer genomics, NGS, single-cell & spatial transcriptomics
💻 R/Bioconductor, Python, Linux HPC
🇬🇧 Fluent English

📩 Send your CV with Ref: AIPOSBIOINFCAM25II to empleo@cnio.es

ℹ️ Full info: tinyurl.com/4hcskvtt
Postdoctoral Research Assistant for the Bioinformatics Unit
DescripciónThe Bioinformatics Unit within the Cancer Genomics programme is seeking to recruit a highly motivated and talented post-doctoral bioinformatician. The selected candidate will work in the co...
www.cnio.es
November 24, 2025 at 9:25 AM
Reposted by Tomás Di Domenico
stephenturner.us
The Drain of Scientific Publishing arxiv.org/abs/2511.04820
November 13, 2025 at 9:31 AM
Reposted by Tomás Di Domenico
jpascualanaya.bsky.social
🚨 We're hiring! 🚨 Our lab at the University of Málaga, Spain🇪🇸 is looking for a bioinformatician researcher for a postdoc position (1+1 years). Check the ad, and if you're interested, get in touch!
📅 Starting date early 2026, with some flexibility.
🙏Please, RT!
October 30, 2025 at 5:50 PM
Reposted by Tomás Di Domenico
cniostopcancer.bsky.social
La 'biología del big data' ya ajusta más las terapias a cada paciente. 
300 especialistas han presentado sus últimos avances en las XV Jornadas de Bioinformática #JBI2025 (Madrid).
Organizadores:  @bioinformatics.cnio.es, INB/ELIXIR-ES @cnb-csic.bsky.social y @biodata.pt 

La revolución de la bioinformática: descifrar el código de la vida para hacer realidad la medicina personalizada
En biología, descubrir ya no es lo que era. La investigación húmeda, de microscopio y pipeta, ya casi no existe sin la de silicio: programas informáticos que extraen la información oculta en un mar de datos. Esta disciplina en auge, la bioinformática, es la que ayuda a entender qué hace cada variante genética, cada proteína: […]
bit.ly
October 30, 2025 at 12:43 PM
Reposted by Tomás Di Domenico
ebi.embl.org
Learn more in the open access Nature Genetics paper: www.nature.com/articles/s41...
Complete genome assemblies of two mouse subspecies reveal structural diversity of telomeres and centromeres - Nature Genetics
Telomere-to-telomere assemblies of two mouse inbred strains, C57BL/6J and CAST/EiJ, offer improvements over the current mouse reference genome by adding telomere and centromere sequences that lead to ...
www.nature.com
October 27, 2025 at 11:51 AM
Reposted by Tomás Di Domenico
stephenturner.us
What a time to be alive
October 22, 2025 at 8:34 AM
Reposted by Tomás Di Domenico
cniostopcancer.bsky.social
La Fundación Instituto Roche ofrece 4 becas de formación para cursar este máster. Suponen el 80% de la matrícula y este año las han conseguido David Dueñas, Jorge Santos, Mario López y Sofía Trigo. 

¡Enhorabuena!

#CienciaDatosMPP #MPP

El máster que ha impulsado la bioinformática en España se enfoca en la medicina personalizada de precisión
Todos los avances médicos y de investigación de las últimas décadas se sustentan sobre una capacidad humana recientemente adquirida: extraer información valiosa de cantidades ingentes de datos. Es lo que hace la bioinformática, en sí misma un área de investigación cada vez más importante y que en los últimos años también crece de forma sinérgica […]
bit.ly
October 13, 2025 at 11:50 AM
Reposted by Tomás Di Domenico
bsc-cns.bsky.social
🔘Nueva edición del Máster de Bioinformática del BSC, @cniostopcancer.bsky.social, @saludisciii.bsky.social ciii.bsky.social y SEBiot

▶ Codirigido por Fatima Al-Shahrour y @alfonsovalencia.bsky.social, es el segundo en el mundo con la certificación de la @iscb.bsky.social

➡ lnkd.in/gQcwWzi
October 13, 2025 at 1:29 PM
Reposted by Tomás Di Domenico
mrclmb.bsky.social
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Black and white portrait of John Gurdon, 1971
October 8, 2025 at 8:49 AM
Reposted by Tomás Di Domenico
rcastellsg.bsky.social
We’re looking for an enthusiastic postdoc to join our team. 😊

The project focuses on protein design and cryo-EM applied to cancer research. 🔬🧪

The position is fully funded for 3 years.

Please share 🙏

Job description and application details (deadline: October 11th): www.cnio.es/en/empleo/po...
Postdoctoral Research Assistant for the Biomolecular Design and Structural Nanomedicine Group
DescriptionWe are looking for a Postdoctoral Researcher to join Roger Castells-Graells’ lab at the Spanish National Cancer Research Centre (CNIO). The successful candidate will work on innovative biom...
www.cnio.es
October 5, 2025 at 2:32 PM
Reposted by Tomás Di Domenico
bioinformatics.cnio.es
⏰ ¡Última semana para inscribirse en el Máster de Bioinformática del ISCIII! ¡Aún estas a tiempo!
ℹ️ masterbioinformatica.com
📌 Organizado por el @saludisciii.bsky.social @cniostopcancer.bsky.social @bsc-cns.bsky.social
🏅 Acreditación oficial @iscb.bsky.social
🤝 Colaboran SEBiot e Instituto Roche
September 8, 2025 at 9:31 AM
Reposted by Tomás Di Domenico
andrejpaleo.bsky.social
The grave risks for science as the whole of leaving fundamental scientific infrastructure in the hands of for-profit capitalist company. Essential scholarly services should be internationally curated by value-based societies/orders/colleges.
🧪
August 13, 2025 at 8:34 AM
Reposted by Tomás Di Domenico
hpc.social
New #HPC Job! 😎️
HPC Engineer
Location: Madrid, Spain
Employer: Spanish National Cancer Research Centre
Remote: Remote friendly
August 7, 2025 at 3:28 AM
tdido.eu
If you ever thought banking apps blocking you if you don't have a Google account was frustrating, imagine a world where the EU blocks you from accessing resources unless you accept Google's ToS...

github.com/eu-digital-i...
Do not add Google Play Integrity integration · Issue #10 · eu-digital-identity-wallet/av-app-android-wallet-ui
In the README, the following is listed: App and device verification based on Google Play Integrity API and Apple App Attestation I would like to strongly urge to abandon this plan. Requiring a depe...
github.com
July 28, 2025 at 8:22 AM
tdido.eu
At @bioinformatics.cnio.es, we're looking for an HPC engineer to help us boost the scientific computing infrastructure at @cniostopcancer.bsky.social. Apply or get in touch for more details!

www.cnio.es/empleo/advan...
Advanced Degree for the Bioinformatics Unit
DescripciónThe Bioinformatics Unit within the Cancer Genomics programme is seeking to recruit a highly a highly motivated and talented High-Performance Computing (HPC) expert specialized in scientific...
www.cnio.es
July 17, 2025 at 11:03 AM
Reposted by Tomás Di Domenico
bioinformatics.cnio.es
🔔 Abierto el 2º plazo de preinscripción del Máster en Bioinformática del ISCIII
🧬 Aún nos quedan plazas...¡pero son limitadas!
📆 ¡No pierdas la oportunidad! ¡Aún estás a tiempo!
📚 Organizado por @saludisciii.bsky.social @cniostopcancer.bsky.social @bsc-cns.bsky.social
👉 masterbioinformatica.com
July 15, 2025 at 8:27 AM
Reposted by Tomás Di Domenico
carlbergstrom.com
A few months ago, Nature published how-to guide for using ChatGPT to write your peer reviews in 30 minutes.

This is, of course, a horrible idea. Here’s my response with @jbakcoleman.bsky.social .
AI, peer review and the human activity of science
When researchers cede their scientific judgement to machines, we lose something important.
www.nature.com
June 25, 2025 at 1:01 PM
Reposted by Tomás Di Domenico
jjvincent.bsky.social
clear, depressing set of observations from @randomwalker.bsky.social - "The decline of reading-for-pleasure (due to video) and reading-for-information (due to AI) will accelerate each other, as reading text without an intermediary will come to be seen as a chore."
"A hypothesis on the accelerating decline of reading: * Broadly speaking, people read for pleasure/entertainment and for learning/obtaining information. * Reading for pleasure has been declining for a while and is being replaced by videos (very sharply among young people). This trend will surely continue. * Reading for obtaining information is getting intermediated by chatbots. We are in the very early stages of this shift, so I think people underappreciate the magnitude of what's coming. It's not just that AI replacing traditional web search. Even when it comes to reading news articles, business documents, or scientific papers, the vision that tech companies are pushing on us is AI summarization + synthesis + Q&A. * We don't have to accept this, but I predict that most people will. It's a tradeoff between speed/convenience and accuracy/depth of understanding — the same tradeoff that was once offered to us when it became possible to search the web to look up a quick fact as opposed to reading about the topic in depth in an encyclopedia. * Just as most people in most cases prefer a shallow web search over deeper reading, most people in most cases will prefer AI-intermediated access to knowledge. Traditional reading won't disappear, but people will do it vastly less often, except in hobbyist reading communities and professions where traditional reading is needed. * The decline of reading-for-pleasure (due to video) and reading-for-information (due to AI) will accelerate each other, as reading text without an intermediary will come to be seen as a chore. * Personally, I find this sad. But while it's tempting to moralize all this, I think that's unproductive. Yelling at individuals to resist new media has been done for centuries and has never worked. * Even if people individually rationally choose these tradeoffs, I think we collectively lose something; critical reading skills are arguably essential for a democracy. We need to figure out what to do about that.
May 22, 2025 at 2:31 PM
Reposted by Tomás Di Domenico
navinbr.bsky.social
Glad to see this out, and to have contributed in a miniscule way to what will hopefully be an excellent resource: long read assemblies of 17 strains of mice www.biorxiv.org/content/10.1...
The mouse pangenome reveals the structural complexity of the murine protein coding landscape
We present the first mouse pangenome consisting of 17 high-quality inbred mouse strain genomes with complete annotation. This collection includes 12 widely used classical laboratory strains and 5 wild...
www.biorxiv.org
May 14, 2025 at 11:00 AM
Reposted by Tomás Di Domenico
bioinformatics.cnio.es
¡Abierta la preinscripción del Máster en Bioinformática y Ciencias de Datos en Medicina Personalizada de Precisión y Salud 2025/26!
📍Organizan: @saludisciii.bsky.social @cniostopcancer.bsky.social @bsc-cns.bsky.social
🤝 Colaboran: SEBiot,Instituto Roche
📅 Plazas limitadas
🔗 masterbioinformatica.com
May 12, 2025 at 8:45 AM
Reposted by Tomás Di Domenico
bioinformatics.cnio.es
🚀 Registration and abstract submissions are NOW OPEN for #JBI2025!
🗓️ Oct 22–24, 2025, in Madrid, Spain
🤝 Spain and Portugal #Bioinformatics and #ComputationalBiology communities

📰 Submit your work: abstract for talk/poster and highlight papers
🔗 jbi2025.cnb.csic.es
April 23, 2025 at 8:57 AM
tdido.eu
I started experimenting with @nanoporetech.com long-read sequencing technology more than 10 years ago. A couple of years back it became my main focus, and we finally have our first results out:

www.medrxiv.org/content/10.1...
Multi-Omic Profiling Reveals Epigenetic Drivers of Immunotherapy Resistance in Multiple Myeloma
Targeted immunotherapies against B-cell maturation antigen (BCMA) have transformed the treatment landscape of Multiple Myeloma (MM). Fc receptor-like 5 (FCRL5) has emerged as an alternative target. Ho...
www.medrxiv.org
April 22, 2025 at 9:12 AM
tdido.eu
When the first (promising) image-generating models appeared a few years ago I thought that maybe ~10 years later we'd be able to prompt our way into fixing the disaster that Episode IX was.

I think my prediction may not be too far off.
March 26, 2025 at 10:43 AM
tdido.eu
"We estimate the supply-side value of widely-used OSS is $4.15 billion, but that the demand-side value is much larger at $8.8 trillion. We find that firms would need to spend 3.5 times more on software than they currently do if OSS did not exist."

simonwillison.net/2025/Mar/26/...
A quote from Manuel Hoffmann, Frank Nagle, Yanuo Zhou
We estimate the supply-side value of widely-used OSS is $4.15 billion, but that the demand-side value is much larger at $8.8 trillion. We find that firms would need to spend …
simonwillison.net
March 26, 2025 at 9:23 AM