Taki Nishimura
@takinishimura.bsky.social
Professor at Osaka University | CLiB assay, Lipid-binding probe, Autophagy and Membrane biology
Reposted by Taki Nishimura
Super cool: a glycosylated polyene polyketide that has potent antifungal activity by targeting several phospholipids to permeabilize membranes!
#lipidtime
#lipidtime
Discovery of a cool new anti-fungal natural project with new #lipidtime mechanism!
Nature research paper: A polyene macrolide targeting phospholipids in the fungal cell membrane ttps://www.nature.com/articles/s41586-025-08678-9
March 19, 2025 at 5:32 PM
Super cool: a glycosylated polyene polyketide that has potent antifungal activity by targeting several phospholipids to permeabilize membranes!
#lipidtime
#lipidtime
Reposted by Taki Nishimura
🚨New preprint: There's this overlooked phospholipid with 3 acyl tails called NAPE that is made during ischemia. We identified its interactome & found it regulates lactate flux, suggesting metabolic functions in response to hypoxia. Congrats to Dylan Chiu! doi.org/10.26434/che... #lipidtime #chembio
March 6, 2025 at 3:15 PM
🚨New preprint: There's this overlooked phospholipid with 3 acyl tails called NAPE that is made during ischemia. We identified its interactome & found it regulates lactate flux, suggesting metabolic functions in response to hypoxia. Congrats to Dylan Chiu! doi.org/10.26434/che... #lipidtime #chembio
Reposted by Taki Nishimura
Spatiotemporal temperature control by holographic heating microscopy unveils cellular thermosensitive calcium signaling https://www.biorxiv.org/content/10.1101/2025.01.09.632068v1
January 14, 2025 at 6:47 PM
Spatiotemporal temperature control by holographic heating microscopy unveils cellular thermosensitive calcium signaling https://www.biorxiv.org/content/10.1101/2025.01.09.632068v1
Reposted by Taki Nishimura
Very cool #lipidtime preprint from Taki Nishimura and colleagues: engineering of new lipid-binding probes from PH domains and nanobodies from a high-throughput assay where liposomes bind to cell surfaces displaying members of the protein probe library. www.biorxiv.org/content/10.1...
Rational engineering of lipid-binding probes via high-throughput protein-lipid interaction screening
Lipid-binding domains, originally isolated from natural proteins, are useful tools essential for analyzing membrane lipids in cells, and their applications are varied. Yet, there is no general strateg...
www.biorxiv.org
January 7, 2025 at 8:42 PM
Very cool #lipidtime preprint from Taki Nishimura and colleagues: engineering of new lipid-binding probes from PH domains and nanobodies from a high-throughput assay where liposomes bind to cell surfaces displaying members of the protein probe library. www.biorxiv.org/content/10.1...