Tobias Komar
@t-komar.bsky.social
PhD candidate exploring Innate Immunity and TLRs | Hornung lab @ Gene Center Munich LMU
Excited to share the first paper of my PhD, published in the Journal of Biological Chemistry.
Huge thanks to all authors, especially to co-first author Stefan Bauernfried, Alex Horswill‘s lab and @mannlab.bsky.social, and my supervisor @v-hornung.bsky.social.
www.jbc.org/article/S002...
Huge thanks to all authors, especially to co-first author Stefan Bauernfried, Alex Horswill‘s lab and @mannlab.bsky.social, and my supervisor @v-hornung.bsky.social.
www.jbc.org/article/S002...
Inflammasome-independent IL-1β activation via staphopain A protease of Staphylococcus aureus
Interleukin-1β (IL-1β) is a pivotal mediator of innate immunity, essential for orchestrating
the acute inflammatory response. While the canonical activation of IL-1β involves
cleavage of its inactive ...
www.jbc.org
August 9, 2025 at 4:59 PM
Excited to share the first paper of my PhD, published in the Journal of Biological Chemistry.
Huge thanks to all authors, especially to co-first author Stefan Bauernfried, Alex Horswill‘s lab and @mannlab.bsky.social, and my supervisor @v-hornung.bsky.social.
www.jbc.org/article/S002...
Huge thanks to all authors, especially to co-first author Stefan Bauernfried, Alex Horswill‘s lab and @mannlab.bsky.social, and my supervisor @v-hornung.bsky.social.
www.jbc.org/article/S002...
Reposted by Tobias Komar
Now online! Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds that poor nuclease processing and selective TLR avoidance drive this evasion, offering insight into the molecular basis of immune tolerance to pseudouridine-containing RNA.
dlvr.it
June 27, 2025 at 3:00 PM
Now online! Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
Reposted by Tobias Komar
Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!
Online Now: Structural basis for OAS2 regulation and its antiviral function Online now:
Structural basis for OAS2 regulation and its antiviral function
Merold and Bekere et al. reveal that OAS2 exists as a zinc-mediated dimer in an autoinhibited state, preventing autoreactivity to short RNAs. Dimer-to-monomer transition, dsRNA binding to a non-canonical interface, and targeting to the Golgi by myristoylation are necessary for OAS2 activation and restriction of viruses that form double membrane vesicles.
dlvr.it
May 23, 2025 at 4:31 PM
Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!
Reposted by Tobias Komar
Wow, so cool!🌟
Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition
Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy
🥂🥳🤩
www.lmu.de/en/newsroom/...
@v-hornung.bsky.social
Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition
Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy
🥂🥳🤩
www.lmu.de/en/newsroom/...
@v-hornung.bsky.social
NUCLEATE Cluster of Excellence: beacon of nucleic acid research
The new NUCLEATE Cluster of Excellence is all about nucleic acids. The research alliance seeks to better understand their various functions and open up new areas of application.
www.lmu.de
May 22, 2025 at 6:03 PM
Wow, so cool!🌟
Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition
Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy
🥂🥳🤩
www.lmu.de/en/newsroom/...
@v-hornung.bsky.social
Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition
Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy
🥂🥳🤩
www.lmu.de/en/newsroom/...
@v-hornung.bsky.social
Reposted by Tobias Komar
The full videos are available! Check them out: VEIT HORNUNG @v-hornung.bsky.social @genecenter-lmu.bsky.social
youtu.be/YBVArSDgFMA
youtu.be/YBVArSDgFMA
Veit Hornung, winner of the 2025 Collen Jeantet Prize for Translational Medicine
YouTube video by Fondation Louis-Jeantet
youtu.be
April 17, 2025 at 8:25 AM
The full videos are available! Check them out: VEIT HORNUNG @v-hornung.bsky.social @genecenter-lmu.bsky.social
youtu.be/YBVArSDgFMA
youtu.be/YBVArSDgFMA
Reposted by Tobias Komar
🥂🤩first snapshot of yesterday's award ceremony👇
April 10, 2025 at 10:38 AM
🥂🤩first snapshot of yesterday's award ceremony👇
Reposted by Tobias Komar
I’m very excited to share our first preprint “Structural Basis for OAS2 Regulation and its Antiviral Function” from my postdoc together with Veronika Merold (Vroni) from NTase lab with @oliveiramann.bsky.social www.biorxiv.org/content/10.1...
January 29, 2025 at 7:14 AM
I’m very excited to share our first preprint “Structural Basis for OAS2 Regulation and its Antiviral Function” from my postdoc together with Veronika Merold (Vroni) from NTase lab with @oliveiramann.bsky.social www.biorxiv.org/content/10.1...
Reposted by Tobias Komar
Structural Basis for OAS2 Regulation and its Antiviral Function https://www.biorxiv.org/content/10.1101/2025.01.28.635220v1
January 29, 2025 at 2:46 AM
Structural Basis for OAS2 Regulation and its Antiviral Function https://www.biorxiv.org/content/10.1101/2025.01.28.635220v1
Reposted by Tobias Komar
Gomez-Diaz, @v-hornung.bsky.social et al. show that mice lacking RNase T2 display an inflammatory phenotype in a TLR13-dependent manner, even under germ-free conditions, suggesting that RNase T2 plays an important role in limiting self-RNA recognition https://buff.ly/4jG49Gy
January 24, 2025 at 7:30 PM
Gomez-Diaz, @v-hornung.bsky.social et al. show that mice lacking RNase T2 display an inflammatory phenotype in a TLR13-dependent manner, even under germ-free conditions, suggesting that RNase T2 plays an important role in limiting self-RNA recognition https://buff.ly/4jG49Gy
Reposted by Tobias Komar
VEIT HORNUNG @v-hornung.bsky.social @genecenter-lmu.bsky.social is awarded the 2025 Collen-Jeantet Prize for Translational Medicine for his important contributions to our understanding of how foreign nucleic acids and other non-self signals trigger the innate immune system.
January 21, 2025 at 10:18 AM
VEIT HORNUNG @v-hornung.bsky.social @genecenter-lmu.bsky.social is awarded the 2025 Collen-Jeantet Prize for Translational Medicine for his important contributions to our understanding of how foreign nucleic acids and other non-self signals trigger the innate immune system.