Synlett Journal
@synlettjournal.bsky.social
An international, peer-reviewed #Account and #Letter journal from Thieme reporting research results and current trends in #chemicalsynthesis.
🔗 https://www.thieme.de/de/synlett/journal-information-55964.htm
🔗 https://www.thieme.de/de/synlett/journal-information-55964.htm
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Are you an innovator in #ChemicalSynthesis? Find your audience with SYNLETT!
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...and more!
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Why SYNLETT:
👥 Rapid Select Crowd Review
🤝 Support for Early Career Researchers
💡 Diverse Editorial Board
...and more!
Submit today: buff.ly/2q3gEkL
#Rhodium catalysis with a self-assembling pyridone phosphine ligand enables chemoselective #hydroformylation of protected propargylic alcohols, yielding either 4-siloxy enals or protected 4-hydroxy aldehydes depending on conditions, by Bernhard Breit & co-workers⚡
👉 buff.ly/3XSPD0C
👉 buff.ly/3XSPD0C
November 21, 2025 at 8:01 AM
#Rhodium catalysis with a self-assembling pyridone phosphine ligand enables chemoselective #hydroformylation of protected propargylic alcohols, yielding either 4-siloxy enals or protected 4-hydroxy aldehydes depending on conditions, by Bernhard Breit & co-workers⚡
👉 buff.ly/3XSPD0C
👉 buff.ly/3XSPD0C
H₂-driven CuH catalysis with multifunctional NHC ligands⚡Guanidine- & iminopyridine-appended NHCs expand reactivity to challenging amides & conjugated substrates🔬 Unprecedented substrate scope & a step toward 3d-metal hydrogenations by Johannes Teichert & co-workers
👉 buff.ly/3K4tj1A
👉 buff.ly/3K4tj1A
November 19, 2025 at 8:01 AM
H₂-driven CuH catalysis with multifunctional NHC ligands⚡Guanidine- & iminopyridine-appended NHCs expand reactivity to challenging amides & conjugated substrates🔬 Unprecedented substrate scope & a step toward 3d-metal hydrogenations by Johannes Teichert & co-workers
👉 buff.ly/3K4tj1A
👉 buff.ly/3K4tj1A
Stannylated amino acids & peptides = versatile building blocks🧬 Easily modified via cross-couplings & metal–halogen exchange for natural product synthesis, active ingredients, or radiolabeling🔬 Overview of methods & applications by Uli Kazmaier
#OpenAcess 👉 buff.ly/pBahnhC
#OpenAcess 👉 buff.ly/pBahnhC
November 17, 2025 at 8:01 AM
Stannylated amino acids & peptides = versatile building blocks🧬 Easily modified via cross-couplings & metal–halogen exchange for natural product synthesis, active ingredients, or radiolabeling🔬 Overview of methods & applications by Uli Kazmaier
#OpenAcess 👉 buff.ly/pBahnhC
#OpenAcess 👉 buff.ly/pBahnhC
#Tetraethynylmethane: a rare, thermally unstable building block that’s fascinated chemists for decades🧪 Sebastian Beil @sebastianbeil.bsky.social report its synthesis and initial use in porous materials, though its full potential remains untapped🌟
#alkynes
👉 buff.ly/HTqx7iU
#alkynes
👉 buff.ly/HTqx7iU
November 14, 2025 at 8:01 AM
#Tetraethynylmethane: a rare, thermally unstable building block that’s fascinated chemists for decades🧪 Sebastian Beil @sebastianbeil.bsky.social report its synthesis and initial use in porous materials, though its full potential remains untapped🌟
#alkynes
👉 buff.ly/HTqx7iU
#alkynes
👉 buff.ly/HTqx7iU
Shigeki Sano & co-workers report bis(benzylthio)phosphoryl HWE-type reagents for conjugated allenyl esters, ketones, amides & phosphonodithioates. Higher reactivity vs traditional #HWE reagents & in-situ ketene preparation 🧪
#allenes
#OpenAccess 👉 buff.ly/3zpKRVt
#allenes
#OpenAccess 👉 buff.ly/3zpKRVt
November 12, 2025 at 8:01 AM
Shigeki Sano & co-workers report bis(benzylthio)phosphoryl HWE-type reagents for conjugated allenyl esters, ketones, amides & phosphonodithioates. Higher reactivity vs traditional #HWE reagents & in-situ ketene preparation 🧪
#allenes
#OpenAccess 👉 buff.ly/3zpKRVt
#allenes
#OpenAccess 👉 buff.ly/3zpKRVt
#GreenChemistry in action🌱 Satyanarayana & co-workers use #electrocatalysis as a clean reagent in electro-organic synthesis! From 3° alcohols to selenyl & sulfenyl scaffolds, their work highlights innovation in eco-friendly synthesis⚗️
👉 buff.ly/s7341tl
👉 buff.ly/s7341tl
November 10, 2025 at 8:01 AM
#GreenChemistry in action🌱 Satyanarayana & co-workers use #electrocatalysis as a clean reagent in electro-organic synthesis! From 3° alcohols to selenyl & sulfenyl scaffolds, their work highlights innovation in eco-friendly synthesis⚗️
👉 buff.ly/s7341tl
👉 buff.ly/s7341tl
💥Systematic study of nitrogen heterocycles by Samuel Oger & Gwilherm Evano! Cu-photoredox catalysis + blue light drives exo-dig radical cyclizations of sulfonamides → azetidines, pyrrolidines, piperidines & azepanes💡
#copper #photoredox #alkynes
👉 buff.ly/eFcpFwQ
#copper #photoredox #alkynes
👉 buff.ly/eFcpFwQ
November 7, 2025 at 8:01 AM
💥Systematic study of nitrogen heterocycles by Samuel Oger & Gwilherm Evano! Cu-photoredox catalysis + blue light drives exo-dig radical cyclizations of sulfonamides → azetidines, pyrrolidines, piperidines & azepanes💡
#copper #photoredox #alkynes
👉 buff.ly/eFcpFwQ
#copper #photoredox #alkynes
👉 buff.ly/eFcpFwQ
Reposted by Synlett Journal
🚀 Countdown to SCNOW Virtual Summit, 6–7 Nov! 🌱♻️
Join top experts in sustainable & circular chemistry from #academia, #industry & #policy. Connect, exchange ideas & drive impact.
💻 Register NOW: cassyni.com/s/scnow-virt...
#SCNOWVirtualSummit #SCNOWPosterSession #Sustainability
Join top experts in sustainable & circular chemistry from #academia, #industry & #policy. Connect, exchange ideas & drive impact.
💻 Register NOW: cassyni.com/s/scnow-virt...
#SCNOWVirtualSummit #SCNOWPosterSession #Sustainability
October 28, 2025 at 11:21 AM
🚀 Countdown to SCNOW Virtual Summit, 6–7 Nov! 🌱♻️
Join top experts in sustainable & circular chemistry from #academia, #industry & #policy. Connect, exchange ideas & drive impact.
💻 Register NOW: cassyni.com/s/scnow-virt...
#SCNOWVirtualSummit #SCNOWPosterSession #Sustainability
Join top experts in sustainable & circular chemistry from #academia, #industry & #policy. Connect, exchange ideas & drive impact.
💻 Register NOW: cassyni.com/s/scnow-virt...
#SCNOWVirtualSummit #SCNOWPosterSession #Sustainability
Advancing #phosphole chemistry! ✨ Our Account by Shibo Xu & Koji Hirano highlights regioselective C–H functionalization of benzophospholes via Pd-catalysis, photoredox, & photo-promoted #annulation 💡
#palladium
👉 buff.ly/lHhUqGs
#palladium
👉 buff.ly/lHhUqGs
November 5, 2025 at 8:01 AM
Advancing #phosphole chemistry! ✨ Our Account by Shibo Xu & Koji Hirano highlights regioselective C–H functionalization of benzophospholes via Pd-catalysis, photoredox, & photo-promoted #annulation 💡
#palladium
👉 buff.ly/lHhUqGs
#palladium
👉 buff.ly/lHhUqGs
Tackling the challenge of γ-lactams with chiral α-quaternary carbons! This #Synpacts article by Mengchun Ye & co-workers highlights asymmetric ring decoration & TM-catalyzed carbonylative cyclization, plus future directions🚀
#lactams #catalysis
👉 buff.ly/PGx50Dq
#lactams #catalysis
👉 buff.ly/PGx50Dq
November 3, 2025 at 8:01 AM
Tackling the challenge of γ-lactams with chiral α-quaternary carbons! This #Synpacts article by Mengchun Ye & co-workers highlights asymmetric ring decoration & TM-catalyzed carbonylative cyclization, plus future directions🚀
#lactams #catalysis
👉 buff.ly/PGx50Dq
#lactams #catalysis
👉 buff.ly/PGx50Dq
Reposted by Synlett Journal
📢📜In this #Synpacts (@synlettjournal.bsky.social), we showcase how electrosynthesis enabled the design of innovative diastereo- and enantioselective alkene 1,2-difunctionalization reactions. These contributions have inspired a complementary “Sew & Cut” strategy
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October 31, 2025 at 10:22 AM
📢📜In this #Synpacts (@synlettjournal.bsky.social), we showcase how electrosynthesis enabled the design of innovative diastereo- and enantioselective alkene 1,2-difunctionalization reactions. These contributions have inspired a complementary “Sew & Cut” strategy
www.thieme-connect.com/products/ejo...
www.thieme-connect.com/products/ejo...
First nickel-catalyzed reductive #CrossCoupling of aldehydes & alkenyl halides🚀 Takuya Kurahashi report a stereoconvergent route to allyl alcohols🌟 Enabled by silyl activation & polarity inversion, this strategy tackles a long-standing challenge in synthesis🧪
#nickel
👉 buff.ly/86v9fyB
#nickel
👉 buff.ly/86v9fyB
October 31, 2025 at 8:01 AM
First nickel-catalyzed reductive #CrossCoupling of aldehydes & alkenyl halides🚀 Takuya Kurahashi report a stereoconvergent route to allyl alcohols🌟 Enabled by silyl activation & polarity inversion, this strategy tackles a long-standing challenge in synthesis🧪
#nickel
👉 buff.ly/86v9fyB
#nickel
👉 buff.ly/86v9fyB
Protecting-group-free #glycosylations are reshaping #glycoscience 🧪 From Ca²⁺-mediated regioselective reactions to #Mitsunobu + photoredox strategies, new methods enable direct, selective glycoside synthesis with high efficiency in our Account by Dey & Jayaraman⚡
👉 buff.ly/lGbhN9i
👉 buff.ly/lGbhN9i
October 29, 2025 at 8:02 AM
Protecting-group-free #glycosylations are reshaping #glycoscience 🧪 From Ca²⁺-mediated regioselective reactions to #Mitsunobu + photoredox strategies, new methods enable direct, selective glycoside synthesis with high efficiency in our Account by Dey & Jayaraman⚡
👉 buff.ly/lGbhN9i
👉 buff.ly/lGbhN9i
#Alkene radical anions in the spotlight🧪 In this #Synpacts article, Polyzos & co-workers highlight advances in C(sp³)–C(sp³) bond formation via #photoredox & #electrosynthesis 🔋 Featuring electroreductive alkene–aldehyde coupling enabled by rapid alternating polarity⚡
👉 buff.ly/uarxdeA
👉 buff.ly/uarxdeA
October 27, 2025 at 8:02 AM
#Alkene radical anions in the spotlight🧪 In this #Synpacts article, Polyzos & co-workers highlight advances in C(sp³)–C(sp³) bond formation via #photoredox & #electrosynthesis 🔋 Featuring electroreductive alkene–aldehyde coupling enabled by rapid alternating polarity⚡
👉 buff.ly/uarxdeA
👉 buff.ly/uarxdeA
First MnO₂/I₂-catalyzed one-pot synthesis of benzo[d]imidazo[2,1-b]thiazoles!🚀 G. Anilkumar & co-workers achieve this via an #OrtolevaKing type reaction⚡This work showcases broad substrate scope, delivers good yields, and paves the way to fused #heterocycles 🧪
#manganese #iodine
👉 buff.ly/fh0Goya
#manganese #iodine
👉 buff.ly/fh0Goya
October 24, 2025 at 7:02 AM
First MnO₂/I₂-catalyzed one-pot synthesis of benzo[d]imidazo[2,1-b]thiazoles!🚀 G. Anilkumar & co-workers achieve this via an #OrtolevaKing type reaction⚡This work showcases broad substrate scope, delivers good yields, and paves the way to fused #heterocycles 🧪
#manganese #iodine
👉 buff.ly/fh0Goya
#manganese #iodine
👉 buff.ly/fh0Goya
Creative ligand design meets #GoldCatalysis 🌟 Antonio Echavarren & co-workers @iciq.org unveil novel chiral scaffolds 🧬to tackle #alkyne activation with a focus on 1,6-enyne cycloisomerization & #cycloaddition✨
#OpenAccess 👉 buff.ly/GMT9qrL
#OpenAccess 👉 buff.ly/GMT9qrL
October 22, 2025 at 7:01 AM
Creative ligand design meets #GoldCatalysis 🌟 Antonio Echavarren & co-workers @iciq.org unveil novel chiral scaffolds 🧬to tackle #alkyne activation with a focus on 1,6-enyne cycloisomerization & #cycloaddition✨
#OpenAccess 👉 buff.ly/GMT9qrL
#OpenAccess 👉 buff.ly/GMT9qrL
From classical methods to a dynamic kinetic strategy, Wang & co-workers showcase how #aziridines can be activated with precision✨Their radical–polar crossover (4+3) #cycloaddition unlocks diverse azepines & new paths for N-containing targets 🧪
#synpacts
👉 buff.ly/H5aiDLV
#synpacts
👉 buff.ly/H5aiDLV
October 20, 2025 at 7:02 AM
From classical methods to a dynamic kinetic strategy, Wang & co-workers showcase how #aziridines can be activated with precision✨Their radical–polar crossover (4+3) #cycloaddition unlocks diverse azepines & new paths for N-containing targets 🧪
#synpacts
👉 buff.ly/H5aiDLV
#synpacts
👉 buff.ly/H5aiDLV
Iron-catalyzed & 1,2-cis selective #glycosylation for aminoglycoside synthesis⚡ Broad scope, reiterative use & scalable to multigrams! Mechanistic insights reveal a unique atom-transfer strategy in our #Synpacts by Hao Xu & co-workers
#iron #catalysis
👉 buff.ly/woziH9i
#iron #catalysis
👉 buff.ly/woziH9i
October 17, 2025 at 7:02 AM
Iron-catalyzed & 1,2-cis selective #glycosylation for aminoglycoside synthesis⚡ Broad scope, reiterative use & scalable to multigrams! Mechanistic insights reveal a unique atom-transfer strategy in our #Synpacts by Hao Xu & co-workers
#iron #catalysis
👉 buff.ly/woziH9i
#iron #catalysis
👉 buff.ly/woziH9i
Skeletal editing meets #photochemistry 🌟 Swap, include, or remove atoms to build diverse molecular scaffolds 🧬 A comprehensive overview by Sudipta Raha Roy & co-workers of cutting-edge methods & future opportunities in #DrugDiscovery ✨
👉 buff.ly/uSaPUu0
👉 buff.ly/uSaPUu0
October 15, 2025 at 7:01 AM
Skeletal editing meets #photochemistry 🌟 Swap, include, or remove atoms to build diverse molecular scaffolds 🧬 A comprehensive overview by Sudipta Raha Roy & co-workers of cutting-edge methods & future opportunities in #DrugDiscovery ✨
👉 buff.ly/uSaPUu0
👉 buff.ly/uSaPUu0
Discover the power of Boron in Organic Synthesis 🔬 at the upcoming Thieme #Cheminar!
Join Profs. Varinder Aggarwal (🇬🇧), Andrei Yudin (🇨🇦), and Benjamin Stokes (🇺🇸) — chaired by Prof. Thierry Ollevier, brought to you by @synopenjournal.bsky.social
📅 October 16, 2025 ⏰ 3 PM (GMT+2)
👉 buff.ly/v41RiQI
Join Profs. Varinder Aggarwal (🇬🇧), Andrei Yudin (🇨🇦), and Benjamin Stokes (🇺🇸) — chaired by Prof. Thierry Ollevier, brought to you by @synopenjournal.bsky.social
📅 October 16, 2025 ⏰ 3 PM (GMT+2)
👉 buff.ly/v41RiQI
October 13, 2025 at 8:02 AM
Discover the power of Boron in Organic Synthesis 🔬 at the upcoming Thieme #Cheminar!
Join Profs. Varinder Aggarwal (🇬🇧), Andrei Yudin (🇨🇦), and Benjamin Stokes (🇺🇸) — chaired by Prof. Thierry Ollevier, brought to you by @synopenjournal.bsky.social
📅 October 16, 2025 ⏰ 3 PM (GMT+2)
👉 buff.ly/v41RiQI
Join Profs. Varinder Aggarwal (🇬🇧), Andrei Yudin (🇨🇦), and Benjamin Stokes (🇺🇸) — chaired by Prof. Thierry Ollevier, brought to you by @synopenjournal.bsky.social
📅 October 16, 2025 ⏰ 3 PM (GMT+2)
👉 buff.ly/v41RiQI
Ethyl but-3-ynoate as a versatile C2 building block🧩 Enables asymmetric (4+2)-heterocycloadditions with Michael acceptors⚡ Chiral isochalcogenoureas deliver highly functionalized #dihydropyrans with excellent selectivity in the study by Waser & co-workers✨
#organocatalysis
👉 buff.ly/NlVUSKk
#organocatalysis
👉 buff.ly/NlVUSKk
October 13, 2025 at 7:02 AM
Ethyl but-3-ynoate as a versatile C2 building block🧩 Enables asymmetric (4+2)-heterocycloadditions with Michael acceptors⚡ Chiral isochalcogenoureas deliver highly functionalized #dihydropyrans with excellent selectivity in the study by Waser & co-workers✨
#organocatalysis
👉 buff.ly/NlVUSKk
#organocatalysis
👉 buff.ly/NlVUSKk
Reposted by Synlett Journal
🔬 Check out the 2025 #NobelPrize in Chemistry!
This year’s award goes to Susumu Kitagawa, Richard Robson, and Omar M. Yaghi for their pioneering work on metal–organic frameworks (#MOFs), highly porous materials that can capture CO₂, store gases, and even pull water from the air!
👉 buff.ly/Tj6ROAv
This year’s award goes to Susumu Kitagawa, Richard Robson, and Omar M. Yaghi for their pioneering work on metal–organic frameworks (#MOFs), highly porous materials that can capture CO₂, store gases, and even pull water from the air!
👉 buff.ly/Tj6ROAv
October 10, 2025 at 7:02 PM
🔬 Check out the 2025 #NobelPrize in Chemistry!
This year’s award goes to Susumu Kitagawa, Richard Robson, and Omar M. Yaghi for their pioneering work on metal–organic frameworks (#MOFs), highly porous materials that can capture CO₂, store gases, and even pull water from the air!
👉 buff.ly/Tj6ROAv
This year’s award goes to Susumu Kitagawa, Richard Robson, and Omar M. Yaghi for their pioneering work on metal–organic frameworks (#MOFs), highly porous materials that can capture CO₂, store gases, and even pull water from the air!
👉 buff.ly/Tj6ROAv
Vicinal tetrasubstituted carbons remain a tough synthetic challenge🔬 Sohtome & Sodeoka (RIKEN) unveil a catalytic aerobic #carbooxygenation strategy that balances uphill & downhill energy profiles, enabling efficient construction of these demanding motifs⚡
👉 buff.ly/eBuOgso
👉 buff.ly/eBuOgso
October 10, 2025 at 7:01 AM
Vicinal tetrasubstituted carbons remain a tough synthetic challenge🔬 Sohtome & Sodeoka (RIKEN) unveil a catalytic aerobic #carbooxygenation strategy that balances uphill & downhill energy profiles, enabling efficient construction of these demanding motifs⚡
👉 buff.ly/eBuOgso
👉 buff.ly/eBuOgso
#Cyclopentenones made simple🌟 Haberhauer & co-workers report a metal-free route via halogen-stabilized #carbanion + #thiolate cyclization🚀 Broad functional group tolerance & pharma relevance make this a powerful tool🔬
👉 buff.ly/WQhB4xs
👉 buff.ly/WQhB4xs
October 8, 2025 at 7:01 AM
#Cyclopentenones made simple🌟 Haberhauer & co-workers report a metal-free route via halogen-stabilized #carbanion + #thiolate cyclization🚀 Broad functional group tolerance & pharma relevance make this a powerful tool🔬
👉 buff.ly/WQhB4xs
👉 buff.ly/WQhB4xs
Protecting-group-free #glycosylations are reshaping #glycoscience 🧪 From Ca²⁺-mediated regioselective reactions to #Mitsunobu + photoredox strategies, new methods enable direct, selective glycoside synthesis with high efficiency in our Account by Dey & Jayaraman⚡
👉 buff.ly/HRUIAyu
👉 buff.ly/HRUIAyu
October 6, 2025 at 7:01 AM
Protecting-group-free #glycosylations are reshaping #glycoscience 🧪 From Ca²⁺-mediated regioselective reactions to #Mitsunobu + photoredox strategies, new methods enable direct, selective glycoside synthesis with high efficiency in our Account by Dey & Jayaraman⚡
👉 buff.ly/HRUIAyu
👉 buff.ly/HRUIAyu