Swaminathan Lab
@swaminathanlab.bsky.social
Laboratory of Cell and Molecular Mechanobiology at Lund University, Sweden
Interested in all things integrins, adhesions, cytoskeleton, microscopy
Interested in all things integrins, adhesions, cytoskeleton, microscopy
Pinned
Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium
Mechanical stiffening of the extracellular matrix around mature mammary acini induces sequential remodeling phases. An early response disrupts the basement membrane and promotes fibronectin secretion...
advanced.onlinelibrary.wiley.com
🚨Excited to share our new paper where we find that in situ ECM stiffening of mature mammary acini induces BM loss, FN deposition & invasion through α3β1/α5β1–FAK→Piezo1 axis—linking integrin switching to MSCs and epithelial remodelling. Led by the amazing Kabilan Sakthivel
tinyurl.com/stnczkc6
tinyurl.com/stnczkc6
🚨Excited to share our new paper where we find that in situ ECM stiffening of mature mammary acini induces BM loss, FN deposition & invasion through α3β1/α5β1–FAK→Piezo1 axis—linking integrin switching to MSCs and epithelial remodelling. Led by the amazing Kabilan Sakthivel
tinyurl.com/stnczkc6
tinyurl.com/stnczkc6
Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium
Mechanical stiffening of the extracellular matrix around mature mammary acini induces sequential remodeling phases. An early response disrupts the basement membrane and promotes fibronectin secretion...
advanced.onlinelibrary.wiley.com
October 14, 2025 at 4:23 AM
🚨Excited to share our new paper where we find that in situ ECM stiffening of mature mammary acini induces BM loss, FN deposition & invasion through α3β1/α5β1–FAK→Piezo1 axis—linking integrin switching to MSCs and epithelial remodelling. Led by the amazing Kabilan Sakthivel
tinyurl.com/stnczkc6
tinyurl.com/stnczkc6
Reposted by Swaminathan Lab
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology
Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...
www.nature.com
July 22, 2025 at 5:10 PM
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
Reposted by Swaminathan Lab
Just learned that Frank Stahl (of the Meselson and Stahl DNA replication experiment ("the most beautiful experiment in biology") died at the beginning of April, to no fanfare. Here's a lovely video of them reminiscing: www.youtube.com/watch?v=7-tn...
The Most Beautiful Experiment: Meselson and Stahl
YouTube video by Science Communication Lab
www.youtube.com
June 26, 2025 at 10:01 AM
Just learned that Frank Stahl (of the Meselson and Stahl DNA replication experiment ("the most beautiful experiment in biology") died at the beginning of April, to no fanfare. Here's a lovely video of them reminiscing: www.youtube.com/watch?v=7-tn...
The feeling when you get back to the lab after a week at a gordon conference - totally inspired and energised after hearing incredible science and meeting amazing people. Thank you @tanentzapflab.bsky.social and @sarawickstrom.bsky.social for GRC Fibronectin, Integrins and related molecules.
Amazed Inspired GIF
Alt: Amazed Inspired GIF
media.tenor.com
May 12, 2025 at 8:55 AM
The feeling when you get back to the lab after a week at a gordon conference - totally inspired and energised after hearing incredible science and meeting amazing people. Thank you @tanentzapflab.bsky.social and @sarawickstrom.bsky.social for GRC Fibronectin, Integrins and related molecules.
Fantastic surprise to have Reinhard Fässler visit Lund to talk about kindlins, integrins and mitosis.
April 24, 2025 at 11:08 AM
Fantastic surprise to have Reinhard Fässler visit Lund to talk about kindlins, integrins and mitosis.
Reposted by Swaminathan Lab
Join us for innovative explorations of the tumor microenvironment🔬 Learn cutting-edge technologies and grow in a dynamic environment💡 The postdoc will work alongside a doctoral student from @adaptmet.bsky.social, gaining access to collaborative partners across 🇪🇺.
Apply now👇
tinyurl.com/4mby45hf
Apply now👇
tinyurl.com/4mby45hf
Postdoc in Experimental Oncology - Lund (Stad), Skåne (SE) job with Lund University | 12838990
Lunds universitet, 009999 LUNDS UNIVERSITET, 310000 MED Lund University was founded in 1666 and is repeatedly ranked among the world’s top universi...
tinyurl.com
April 23, 2025 at 5:56 AM
Join us for innovative explorations of the tumor microenvironment🔬 Learn cutting-edge technologies and grow in a dynamic environment💡 The postdoc will work alongside a doctoral student from @adaptmet.bsky.social, gaining access to collaborative partners across 🇪🇺.
Apply now👇
tinyurl.com/4mby45hf
Apply now👇
tinyurl.com/4mby45hf
Seems like a good time to share and appreciate this incredible
window to future cancer treatments and the opportunities ahead (and also appreciate its journey from test tubes to bacteria to cell culture to animal models to covid vaccine and now to this-)
www.nature.com/articles/s41...
window to future cancer treatments and the opportunities ahead (and also appreciate its journey from test tubes to bacteria to cell culture to animal models to covid vaccine and now to this-)
www.nature.com/articles/s41...
RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer - Nature
In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked lo...
www.nature.com
March 17, 2025 at 8:58 AM
Seems like a good time to share and appreciate this incredible
window to future cancer treatments and the opportunities ahead (and also appreciate its journey from test tubes to bacteria to cell culture to animal models to covid vaccine and now to this-)
www.nature.com/articles/s41...
window to future cancer treatments and the opportunities ahead (and also appreciate its journey from test tubes to bacteria to cell culture to animal models to covid vaccine and now to this-)
www.nature.com/articles/s41...
So many heartbreaking stories right now coming from the US. Joe was a post-doc fellow here at WCMM Lund University and moved back to Fort Collins for family and career.
www.cbsnews.com/colorado/new...
www.cbsnews.com/colorado/new...
Colorado CDC researcher terminated amid federal budget cuts while working on Lyme disease projects
Colorado research biologist Joe Cardiello was excited about being involved in what could become lifesaving research for people who have been impacted by Lyme disease.
www.cbsnews.com
February 24, 2025 at 9:25 AM
So many heartbreaking stories right now coming from the US. Joe was a post-doc fellow here at WCMM Lund University and moved back to Fort Collins for family and career.
www.cbsnews.com/colorado/new...
www.cbsnews.com/colorado/new...
Reposted by Swaminathan Lab
Dear federal scientists: If you have been affected by the probationary firings and would be willing to speak with Science, please reach out to me by email (klangin@aaas.org) or on Signal. We can guarantee annonymity.
February 14, 2025 at 8:05 PM
Dear federal scientists: If you have been affected by the probationary firings and would be willing to speak with Science, please reach out to me by email (klangin@aaas.org) or on Signal. We can guarantee annonymity.
Big first for our lab on Friday as Wesley became its first PhD graduate. Congrats Wesley and a big thanks to an amazing committee including @bengoult.bsky.social (opponent), @sciezgin.bsky.social , Gunilla Westergren-Thorsson, Catharina Hagerling and Daniel Engelbertsen.
February 10, 2025 at 1:23 PM
Big first for our lab on Friday as Wesley became its first PhD graduate. Congrats Wesley and a big thanks to an amazing committee including @bengoult.bsky.social (opponent), @sciezgin.bsky.social , Gunilla Westergren-Thorsson, Catharina Hagerling and Daniel Engelbertsen.
🚨🚨🚨Come and join us at the Wallenberg Center for Molecular Medicine- tenure track positions in broad areas of 1)basic research and 2)advanced therapy in regenerative medicine.
🚨Deadline Feb 10th. DM me if you have any questions
lu.varbi.com/en/what:job/...
lu.varbi.com/en/what:job/...
🚨Deadline Feb 10th. DM me if you have any questions
lu.varbi.com/en/what:job/...
lu.varbi.com/en/what:job/...
February 1, 2025 at 2:21 PM
🚨🚨🚨Come and join us at the Wallenberg Center for Molecular Medicine- tenure track positions in broad areas of 1)basic research and 2)advanced therapy in regenerative medicine.
🚨Deadline Feb 10th. DM me if you have any questions
lu.varbi.com/en/what:job/...
lu.varbi.com/en/what:job/...
🚨Deadline Feb 10th. DM me if you have any questions
lu.varbi.com/en/what:job/...
lu.varbi.com/en/what:job/...
Amazing and beautiful work as usual from @alushinlab.bsky.social
Scientists in the @alushinlab.bsky.social have figured out how cells build a structure that lets them migrate. Unpacking these “finger-like” protein bundles that protrude from cells may lead to novel treatments for metastasis. #RockefellerScience
bit.ly/3PKErmA
bit.ly/3PKErmA
January 29, 2025 at 1:13 PM
Amazing and beautiful work as usual from @alushinlab.bsky.social
I am very excited to (delayed) share our preprint which has been led by Kabilan Sakthivel on mechanisms by which ECM stiffening of normal 3D tissues in their native environment drives invasive phenotypes
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
β1 Integrin–FAK–Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium
Stiffening of tissue is a hallmark of cancer progression, driving invasive phenotypes through complex interactions between cells and their extracellular matrix (ECM). However, the mechanisms linking m...
www.biorxiv.org
January 22, 2025 at 11:33 AM
I am very excited to (delayed) share our preprint which has been led by Kabilan Sakthivel on mechanisms by which ECM stiffening of normal 3D tissues in their native environment drives invasive phenotypes
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Swaminathan Lab
For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...
2025 Fibronectin, Integrins and Related Molecules (GRS) Seminar GRC
The 2025 Gordon Research Seminar on Fibronectin, Integrins and Related Molecules (GRS) will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 20, 2025 at 11:17 AM
For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...
Reposted by Swaminathan Lab
Are you working on #ECM or mechanobiology in the mammary gland or in breast cancer? Together with Jason Northey we are guest editing a collection on the topic for the Journal of Mammary gland biology and Neoplasia. Submission of articles is now open! link.springer.com/collections/...
January 20, 2025 at 2:34 PM
Are you working on #ECM or mechanobiology in the mammary gland or in breast cancer? Together with Jason Northey we are guest editing a collection on the topic for the Journal of Mammary gland biology and Neoplasia. Submission of articles is now open! link.springer.com/collections/...
This is a scientific life changing experience-
The deadline to apply for the MBL Physiology course is fast approaching, January 27th! Consider applying to this amazing, life-changing research discovery experience in Woods Hole! www.mbl.edu/education/ad...
Physiology: Modern Cell Biology Using Microscopic, Biochemical and Computational Approaches | Marine Biological Laboratory
This course is at the forefront of new tools — molecular, computational, biophysical — as it prepares students to tackle emerging biological questions.
www.mbl.edu
January 20, 2025 at 7:38 AM
This is a scientific life changing experience-
Reposted by Swaminathan Lab
Hey PIs, do your trainees need to learn light microscopy and image analysis? Send them to us! Financial aid is available.
meetings.cshl.edu/coursesinten...
meetings.cshl.edu/coursesinten...
Courses Intent to Apply Form
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
January 13, 2025 at 6:02 PM
Hey PIs, do your trainees need to learn light microscopy and image analysis? Send them to us! Financial aid is available.
meetings.cshl.edu/coursesinten...
meetings.cshl.edu/coursesinten...
Crazy!- A rare case of malignant tumor transplantation from patient to surgeon:
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Genetic Analysis of a Sarcoma Accidentally Transplanted from a Patient to a Surgeon | NEJM
Modern concepts of cancer immunology originated from the classic observations by Jensen, Loeb, Tyzzer, and Little in the early years of the 20th century of the rejection of transplanted allogeneic ...
www.nejm.org
January 9, 2025 at 2:58 PM
Crazy!- A rare case of malignant tumor transplantation from patient to surgeon:
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Swaminathan Lab
Sakthivel K, et al. {beta}1 Integrin-FAK-Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium. bioRxiv posted 8 January 2025 doi:10.1101/2025.01.07.631639. www.biorxiv.org/content/10.1...
β1 Integrin–FAK–Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium
Stiffening of tissue is a hallmark of cancer progression, driving invasive phenotypes through complex interactions between cells and their extracellular matrix (ECM). However, the mechanisms linking m...
www.biorxiv.org
January 9, 2025 at 10:13 AM
Sakthivel K, et al. {beta}1 Integrin-FAK-Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium. bioRxiv posted 8 January 2025 doi:10.1101/2025.01.07.631639. www.biorxiv.org/content/10.1...
Reposted by Swaminathan Lab
In all seriousness,use CiteAb and Antibodypedia, look for KO/KD validated antibodies, best - recombinant, second best - monoclonal, and if possible do your own KO/KD controls, or induction by ligand/small molecule,if not - compare hyperexpressing with low expressing cells (from depmap/protein atlas)
December 26, 2024 at 6:31 AM
In all seriousness,use CiteAb and Antibodypedia, look for KO/KD validated antibodies, best - recombinant, second best - monoclonal, and if possible do your own KO/KD controls, or induction by ligand/small molecule,if not - compare hyperexpressing with low expressing cells (from depmap/protein atlas)
Reposted by Swaminathan Lab
Pre-announcing the 10th Biennial European CellMech conference organized in Leuven 🇧🇪 from September 30th to October 3rd, 2025.
cellmech2025.org
Save the date !
cellmech2025.org
Save the date !
November 21, 2024 at 9:34 PM
Pre-announcing the 10th Biennial European CellMech conference organized in Leuven 🇧🇪 from September 30th to October 3rd, 2025.
cellmech2025.org
Save the date !
cellmech2025.org
Save the date !
Reposted by Swaminathan Lab
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at:
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
November 25, 2024 at 2:44 PM
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at:
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
The GRC scam emails are getting quite good, huh?
November 25, 2024 at 1:02 PM
The GRC scam emails are getting quite good, huh?
Seems like a good time to post this:
Our centre is recruiting a tenure-track PI with focus on basic research into regenerative medicine and disease mechanisms. Excellent start-up package, colleagues & infrastructure in a fantastic college town.Other useful links below
lu.varbi.com/en/what:job/...
Our centre is recruiting a tenure-track PI with focus on basic research into regenerative medicine and disease mechanisms. Excellent start-up package, colleagues & infrastructure in a fantastic college town.Other useful links below
lu.varbi.com/en/what:job/...
Associate Senior Lecturer (WCMM Fellow) in Molecular Medicine with a focus on basic research into regenerative medicine and disease mechanisms
In this call for proposals ( Wallenberg Molecular Medicine Fellow ), we are looking for prominent researchers with international research experience. The position is located at the Faculty of Medicine
lu.varbi.com
November 14, 2024 at 8:10 AM
Seems like a good time to post this:
Our centre is recruiting a tenure-track PI with focus on basic research into regenerative medicine and disease mechanisms. Excellent start-up package, colleagues & infrastructure in a fantastic college town.Other useful links below
lu.varbi.com/en/what:job/...
Our centre is recruiting a tenure-track PI with focus on basic research into regenerative medicine and disease mechanisms. Excellent start-up package, colleagues & infrastructure in a fantastic college town.Other useful links below
lu.varbi.com/en/what:job/...
Reposted by Swaminathan Lab
I started a list of people working broadly on cell adhesion and cell migration. I likely missed many, please drop me a message if you want to be added
go.bsky.app/5Gzo7oZ
go.bsky.app/5Gzo7oZ
November 11, 2024 at 1:09 PM
I started a list of people working broadly on cell adhesion and cell migration. I likely missed many, please drop me a message if you want to be added
go.bsky.app/5Gzo7oZ
go.bsky.app/5Gzo7oZ