Megan Chastney
@mchastney.bsky.social
Cell biologist interested in cell adhesion, cancer and mechanobiology. Postdoc at Turku Bioscience, Finland
Reposted by Megan Chastney
Very happy to share Niklas Jäntti's PhD work on EPLIN /LIMA1 isoforms (α/β) in breast cancer (spoiler: both have opposing roles in integrin traffic, cell migration & clinical outcome). This might explain why EPLIN sometimes has been reported as pro- and sometimes as anti-tumorigenic: bit.ly/3Iwjtau
EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration
Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…
bit.ly
July 16, 2025 at 6:01 AM
Very happy to share Niklas Jäntti's PhD work on EPLIN /LIMA1 isoforms (α/β) in breast cancer (spoiler: both have opposing roles in integrin traffic, cell migration & clinical outcome). This might explain why EPLIN sometimes has been reported as pro- and sometimes as anti-tumorigenic: bit.ly/3Iwjtau
Reposted by Megan Chastney
We are very proud to announce @johannaivaska.bsky.social as the recipient of the Biennial Finnish Science Award, given by the Finnish Ministry of Education & Culture. Johanna was described as a distinguished researcher with pioneering work in cell biology. Warmest congrats from all of us, boss!
May 20, 2025 at 10:32 AM
We are very proud to announce @johannaivaska.bsky.social as the recipient of the Biennial Finnish Science Award, given by the Finnish Ministry of Education & Culture. Johanna was described as a distinguished researcher with pioneering work in cell biology. Warmest congrats from all of us, boss!
Reposted by Megan Chastney
New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...
May 26, 2025 at 10:29 AM
New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...
Reposted by Megan Chastney
Congratulations to Pat Caswell (@integrintraffic.bsky.social) & Alexandra Naba (@matrisome.bsky.social) who will be vice-chairs of the 2027 Fibronectin, Integrins & Related Molecules GRC and chairs of the 2029 meeting!
May 8, 2025 at 12:09 PM
Congratulations to Pat Caswell (@integrintraffic.bsky.social) & Alexandra Naba (@matrisome.bsky.social) who will be vice-chairs of the 2027 Fibronectin, Integrins & Related Molecules GRC and chairs of the 2029 meeting!
Reposted by Megan Chastney
Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
Adhesion-derived condensates control component availability to regulate adhesion dynamics
Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...
www.biorxiv.org
May 9, 2025 at 2:23 PM
Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
Reposted by Megan Chastney
Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
Macrophages promote collagen deposition through circadian regulation of fibroblasts
Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...
www.biorxiv.org
March 5, 2025 at 8:28 AM
Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Megan Chastney
Maybe of interest to the talented ECR network of @themeshwork.bsky.social ? www.manchester.ac.uk/research/bic...
Bicentenary PhD Studentships and Fellowships | The University of Manchester
Learn more about the Bicentenary PhD Studentships and Fellowships launched as part of The University of Manchester's 200th year.
www.manchester.ac.uk
March 5, 2025 at 11:07 AM
Maybe of interest to the talented ECR network of @themeshwork.bsky.social ? www.manchester.ac.uk/research/bic...
Reposted by Megan Chastney
#ECMatrix researchers, please share:
Just under 2 weeks until the abstract deadline (21st Feb) for the 3-day Matrix Nexus meeting in Freiburg. Topics include #cancer #collagens #proteoglycans #proteases #tissueengineering & a session dedicated to #ECRs!
www.matrixbiologie.de/annual-meeti...
Just under 2 weeks until the abstract deadline (21st Feb) for the 3-day Matrix Nexus meeting in Freiburg. Topics include #cancer #collagens #proteoglycans #proteases #tissueengineering & a session dedicated to #ECRs!
www.matrixbiologie.de/annual-meeti...
February 10, 2025 at 1:07 PM
#ECMatrix researchers, please share:
Just under 2 weeks until the abstract deadline (21st Feb) for the 3-day Matrix Nexus meeting in Freiburg. Topics include #cancer #collagens #proteoglycans #proteases #tissueengineering & a session dedicated to #ECRs!
www.matrixbiologie.de/annual-meeti...
Just under 2 weeks until the abstract deadline (21st Feb) for the 3-day Matrix Nexus meeting in Freiburg. Topics include #cancer #collagens #proteoglycans #proteases #tissueengineering & a session dedicated to #ECRs!
www.matrixbiologie.de/annual-meeti...
Reposted by Megan Chastney
🚀 SAVE THE DATE! The 4th BioImage Informatics Finland (BIIF) Symposium is happening 📅 May 22-23, 2025!
Join researchers & facility experts to discuss the latest in image analysis & data management.
📍Seili, Turku Archipelago 🇫🇮
Stay tuned for program & registration #BIIF2025
Photo: Visit Seili
Join researchers & facility experts to discuss the latest in image analysis & data management.
📍Seili, Turku Archipelago 🇫🇮
Stay tuned for program & registration #BIIF2025
Photo: Visit Seili
February 11, 2025 at 9:27 AM
🚀 SAVE THE DATE! The 4th BioImage Informatics Finland (BIIF) Symposium is happening 📅 May 22-23, 2025!
Join researchers & facility experts to discuss the latest in image analysis & data management.
📍Seili, Turku Archipelago 🇫🇮
Stay tuned for program & registration #BIIF2025
Photo: Visit Seili
Join researchers & facility experts to discuss the latest in image analysis & data management.
📍Seili, Turku Archipelago 🇫🇮
Stay tuned for program & registration #BIIF2025
Photo: Visit Seili
Reposted by Megan Chastney
I put together a small guide on how to get started with Fiji. Please distribute to anyone who might benefit form this! zenodo.org/records/1477... #imageanalysis #fiji #imagej #training
Image handling using Fiji - training materials
Description:This training package provides a guide to image processing and analysis using ImageJ/Fiji, an open-source software widely used in biological and medical imaging. The manual includes step-b...
zenodo.org
January 30, 2025 at 3:10 PM
I put together a small guide on how to get started with Fiji. Please distribute to anyone who might benefit form this! zenodo.org/records/1477... #imageanalysis #fiji #imagej #training
The deadline for abstract submission has now been extended until the 10th Feb!
For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...
2025 Fibronectin, Integrins and Related Molecules (GRS) Seminar GRC
The 2025 Gordon Research Seminar on Fibronectin, Integrins and Related Molecules (GRS) will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 28, 2025 at 8:25 AM
The deadline for abstract submission has now been extended until the 10th Feb!
Reposted by Megan Chastney
We are hiring!!
How do basement membranes become stable structures during tissue growth? How can we measure turnover and dynamics?
Come and join our team to help us answer these questions!
@mcrcellmatrix.bsky.social
@stramerlab.bsky.social
More info 👇
www.jobs.ac.uk/job/DLN927/r...
How do basement membranes become stable structures during tissue growth? How can we measure turnover and dynamics?
Come and join our team to help us answer these questions!
@mcrcellmatrix.bsky.social
@stramerlab.bsky.social
More info 👇
www.jobs.ac.uk/job/DLN927/r...
Research Associate - Mechanisms Associated with Extracellular Matrix Assembly and Stability at The University of Manchester
Apply for the Research Associate - Mechanisms Associated with Extracellular Matrix Assembly and Stability role on jobs.ac.uk, the top job board for academic positions in higher education. View details...
www.jobs.ac.uk
January 27, 2025 at 10:08 AM
We are hiring!!
How do basement membranes become stable structures during tissue growth? How can we measure turnover and dynamics?
Come and join our team to help us answer these questions!
@mcrcellmatrix.bsky.social
@stramerlab.bsky.social
More info 👇
www.jobs.ac.uk/job/DLN927/r...
How do basement membranes become stable structures during tissue growth? How can we measure turnover and dynamics?
Come and join our team to help us answer these questions!
@mcrcellmatrix.bsky.social
@stramerlab.bsky.social
More info 👇
www.jobs.ac.uk/job/DLN927/r...
Reposted by Megan Chastney
A reminder to colleagues interested in Cell-Matrix adhesion & anything ECM related that registration is now open for the Fibronectin, Integrins & related molecules Gordon Research Conference. Incredible list speakers! incredible location! it will 🔥 🔥 🔥 Please join us! www.grc.org/fibronectin-...
2025 Fibronectin, Integrins and Related Molecules Conference GRC
The 2025 Gordon Research Conference on Fibronectin, Integrins and Related Molecules will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 22, 2025 at 4:54 AM
A reminder to colleagues interested in Cell-Matrix adhesion & anything ECM related that registration is now open for the Fibronectin, Integrins & related molecules Gordon Research Conference. Incredible list speakers! incredible location! it will 🔥 🔥 🔥 Please join us! www.grc.org/fibronectin-...
For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...
2025 Fibronectin, Integrins and Related Molecules (GRS) Seminar GRC
The 2025 Gordon Research Seminar on Fibronectin, Integrins and Related Molecules (GRS) will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 20, 2025 at 11:17 AM
For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...
Reposted by Megan Chastney
Very glad to see this study finally out (and mentioned on bsky already!)- it's been a huge #collaboration across different groups🙏🏻
Fibroblasts recycles (in a #circadian manner) #collagen to make new fibrils, which is enhanced in #fibrosis.
doi.org/10.7554/eLif...
@elife.bsky.social
Fibroblasts recycles (in a #circadian manner) #collagen to make new fibrils, which is enhanced in #fibrosis.
doi.org/10.7554/eLif...
@elife.bsky.social
Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis
Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in ...
doi.org
January 16, 2025 at 2:29 PM
Very glad to see this study finally out (and mentioned on bsky already!)- it's been a huge #collaboration across different groups🙏🏻
Fibroblasts recycles (in a #circadian manner) #collagen to make new fibrils, which is enhanced in #fibrosis.
doi.org/10.7554/eLif...
@elife.bsky.social
Fibroblasts recycles (in a #circadian manner) #collagen to make new fibrils, which is enhanced in #fibrosis.
doi.org/10.7554/eLif...
@elife.bsky.social
Reposted by Megan Chastney
📣 Everything you always wanted to know about the #ECM (but were afraid to ask). Join me at @themeshwork.bsky.social seminar series in December to learn about the latest developments of the #Matrisome project @matrisome.bsky.social! Sign up here forms.gle/W3QFUheh9hf5... and help us spread the word!
November 26, 2024 at 3:35 AM
📣 Everything you always wanted to know about the #ECM (but were afraid to ask). Join me at @themeshwork.bsky.social seminar series in December to learn about the latest developments of the #Matrisome project @matrisome.bsky.social! Sign up here forms.gle/W3QFUheh9hf5... and help us spread the word!
Reposted by Megan Chastney
Here is the most recent preprint from our most recent PhD graduate, Dr Nicolas Pasquier. Orientation of mucinous CRC apicobasal polarity is regulated by tumor-stroma interactions. This work was a collaboration with the Jaulin lab at the Gustave Roussy Institute.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity
Mucinous colorectal carcinoma (MUC CRC) dissemination into the tumor stroma and metastasis to multiple organs, including the peritoneum, is associated with poor prognosis. Disseminating MUC CRCs exhib...
www.biorxiv.org
November 21, 2024 at 12:58 PM
Here is the most recent preprint from our most recent PhD graduate, Dr Nicolas Pasquier. Orientation of mucinous CRC apicobasal polarity is regulated by tumor-stroma interactions. This work was a collaboration with the Jaulin lab at the Gustave Roussy Institute.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Megan Chastney
Delighted to share our latest paper:
"The glomerular circadian clock temporally regulates basement membrane dynamics and the podocyte glucocorticoid response"
Expertly led by Rebecca Preston & in collaboration with clock superstar Qing Jun Meng
pubmed.ncbi.nlm.nih.gov/39515644/
Key findings 👇👇
November 21, 2024 at 3:39 PM
Delighted to share our latest paper:
"The glomerular circadian clock temporally regulates basement membrane dynamics and the podocyte glucocorticoid response"
Expertly led by Rebecca Preston & in collaboration with clock superstar Qing Jun Meng
pubmed.ncbi.nlm.nih.gov/39515644/
Key findings 👇👇
Reposted by Megan Chastney
Introductory post on 🦋! We're a research group headed by Prof. Johanna Ivaska interested in understanding how integrins contribute to every step of cancer progression. We're located at the Turku Bioscience Center in Turku, Finland! Find out more about us and our interests here: ivaskalab.utu.fi
Ivaska cell adhesion and cancer Lab
Integrins, matrix, motility and mechanotransduction in cancer
ivaskalab.utu.fi
November 19, 2024 at 2:36 PM
Introductory post on 🦋! We're a research group headed by Prof. Johanna Ivaska interested in understanding how integrins contribute to every step of cancer progression. We're located at the Turku Bioscience Center in Turku, Finland! Find out more about us and our interests here: ivaskalab.utu.fi