Sunny Sneed
@sunnysneed.bsky.social
Graduate Student studying regulatory T cells at the Brody School of Medicine at East Carolina University. I love reading, animals, and chill vibes 🩵 Eternally tired. RPI -> UNLV -> RPI -> UTMSI -> MGH -> ECU. https://orcid.org/0000-0002-5683-2151
I'm excited to share my 2nd 1st-author paper, done during my time at MGH, is out today in PNAS! We found that IgGs 1 and 3 have anti-inflammatory behavior when terminally sialylated, while IgGs 2 and 4 do not.
Thank you to all my coauthors! #Immunology #Antibodies www.pnas.org/doi/10.1073/...
Thank you to all my coauthors! #Immunology #Antibodies www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
May 16, 2025 at 5:59 PM
I'm excited to share my 2nd 1st-author paper, done during my time at MGH, is out today in PNAS! We found that IgGs 1 and 3 have anti-inflammatory behavior when terminally sialylated, while IgGs 2 and 4 do not.
Thank you to all my coauthors! #Immunology #Antibodies www.pnas.org/doi/10.1073/...
Thank you to all my coauthors! #Immunology #Antibodies www.pnas.org/doi/10.1073/...
Numbers aren't everything, but this feels pretty special! A great way to start the new year! 🥰
January 2, 2025 at 3:55 PM
Numbers aren't everything, but this feels pretty special! A great way to start the new year! 🥰
Reposted by Sunny Sneed
Immunologists, time to embrace your inner neuroscientist 🧠🧪
Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology
www.nature.com/articles/s41...
Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology
www.nature.com/articles/s41...
Macrophages excite muscle spindles with glutamate to bolster locomotion - Nature
A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component, the muscle s...
www.nature.com
December 11, 2024 at 12:00 PM
Immunologists, time to embrace your inner neuroscientist 🧠🧪
Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology
www.nature.com/articles/s41...
Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology
www.nature.com/articles/s41...
Reposted by Sunny Sneed
There is a human tissue that builds itself up and breaks itself down every 28 days (on average) using non-scarring wound healing and instead of studying that and learning everything we can about it we think it's gross and look for other less relevant models to understand wound healing.
December 3, 2023 at 12:06 AM
There is a human tissue that builds itself up and breaks itself down every 28 days (on average) using non-scarring wound healing and instead of studying that and learning everything we can about it we think it's gross and look for other less relevant models to understand wound healing.
been sick since monday night 🤒😷 please let this be over soon!!
December 5, 2024 at 1:03 AM
been sick since monday night 🤒😷 please let this be over soon!!
Reposted by Sunny Sneed
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 5:58 PM
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
#HappyThanksgiving from the local pups!
November 28, 2024 at 6:16 PM
#HappyThanksgiving from the local pups!
Reposted by Sunny Sneed
Eight years later, I revisit the tree of life. “Future trees may need to distinguish not only between cultured and uncultured lineages, but between extant and extinct”
rdcu.be/dPNpB
rdcu.be/dPNpB
The ever-changing tree of life
Nature Microbiology - The tree of life is a galvanizing image, anchoring biological diversity within a common framework. From a new view in 2016, the tree has continued to grow, and with it, our...
rdcu.be
August 2, 2024 at 8:40 PM
Eight years later, I revisit the tree of life. “Future trees may need to distinguish not only between cultured and uncultured lineages, but between extant and extinct”
rdcu.be/dPNpB
rdcu.be/dPNpB
obligatory bluesky cat post 🐈 🐈⬛
November 27, 2024 at 12:25 AM
obligatory bluesky cat post 🐈 🐈⬛
Reposted by Sunny Sneed
Sectarianism in immunology.
(highly specific for immunologists, all credit to @pedromics on X)
1/8
(highly specific for immunologists, all credit to @pedromics on X)
1/8
November 25, 2024 at 7:35 PM
Sectarianism in immunology.
(highly specific for immunologists, all credit to @pedromics on X)
1/8
(highly specific for immunologists, all credit to @pedromics on X)
1/8
Reposted by Sunny Sneed
The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on?
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
November 19, 2024 at 12:27 PM
The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on?
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
Reposted by Sunny Sneed
Reposted by Sunny Sneed
🚨 If you haven’t seen it yet…
📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition.
Check it out at bioart.niaid.nih.gov
📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition.
Check it out at bioart.niaid.nih.gov
November 23, 2024 at 11:30 PM
🚨 If you haven’t seen it yet…
📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition.
Check it out at bioart.niaid.nih.gov
📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition.
Check it out at bioart.niaid.nih.gov
Reposted by Sunny Sneed
Optimist: the cup is 1/2 full
Pessimist: the cup is 1/2 empty
Excel: the cup is January 2nd
Pessimist: the cup is 1/2 empty
Excel: the cup is January 2nd
August 29, 2024 at 12:40 PM
Optimist: the cup is 1/2 full
Pessimist: the cup is 1/2 empty
Excel: the cup is January 2nd
Pessimist: the cup is 1/2 empty
Excel: the cup is January 2nd
@jake1.bsky.social Hey Jake! I read Invisible Friends a couple months back and wanted to say I really enjoyed it! great job! 🦠💚
November 23, 2024 at 3:50 PM
@jake1.bsky.social Hey Jake! I read Invisible Friends a couple months back and wanted to say I really enjoyed it! great job! 🦠💚
@texasstars.bsky.social any of your guys single??? asking for a friend…
November 23, 2024 at 2:47 AM
@texasstars.bsky.social any of your guys single??? asking for a friend…
currently reading 📖
November 22, 2024 at 6:45 PM
currently reading 📖
Reposted by Sunny Sneed
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 22, 2024 at 3:49 PM
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sunny Sneed
Our new work!
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
November 20, 2024 at 9:55 AM
Our new work!
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
Reposted by Sunny Sneed
Tolerance by eviction
"we report that, in mice, CD8 T cell tolerance instead results from premature thymic eviction of immature autoreactive CD8 thymocytes into the periphery, where they differentiate into self-tolerant mature CD8 T cells"
#Immunology #Immunosky
"we report that, in mice, CD8 T cell tolerance instead results from premature thymic eviction of immature autoreactive CD8 thymocytes into the periphery, where they differentiate into self-tolerant mature CD8 T cells"
#Immunology #Immunosky
CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus
Thymic eviction explains CD8 T cell tolerance and why autoreactive CD8 T cells appear in the periphery but not the thymus.
www.science.org
November 15, 2024 at 10:44 PM
Tolerance by eviction
"we report that, in mice, CD8 T cell tolerance instead results from premature thymic eviction of immature autoreactive CD8 thymocytes into the periphery, where they differentiate into self-tolerant mature CD8 T cells"
#Immunology #Immunosky
"we report that, in mice, CD8 T cell tolerance instead results from premature thymic eviction of immature autoreactive CD8 thymocytes into the periphery, where they differentiate into self-tolerant mature CD8 T cells"
#Immunology #Immunosky
Reposted by Sunny Sneed
Not a new story, but as important as ever to get out there. NIH research not only supports better health but the economy. We know this, but need others to know it also.
Report: Every dollar of NIH research funding doubles in economic returns
Research funded by the National Institutes of Health (NIH) generated $2.46 in economic activity for every $1 of funding in 2023, a total of $92.9 billion, according to an
www.fiercebiotech.com
November 17, 2024 at 1:23 PM
Not a new story, but as important as ever to get out there. NIH research not only supports better health but the economy. We know this, but need others to know it also.
Hi Bluesky! 🩵 I’m Sunny, a 2nd year graduate student at the Brody School of Medicine at East Carolina University! 💜☠️ I’m studying regulatory T cells and how to use them as cell therapies! I love reading, animals, chill vibes, pumpkin spice, my pet fish, and sleeping 😴 #Immunology #Tregs #GradStudent
November 17, 2024 at 3:35 PM
Hi Bluesky! 🩵 I’m Sunny, a 2nd year graduate student at the Brody School of Medicine at East Carolina University! 💜☠️ I’m studying regulatory T cells and how to use them as cell therapies! I love reading, animals, chill vibes, pumpkin spice, my pet fish, and sleeping 😴 #Immunology #Tregs #GradStudent