Suguru Nishijima
suguru-nishijima.bsky.social
Suguru Nishijima
@suguru-nishijima.bsky.social
Project Associate Professor at the Life Science Data Research Center, @UTokyo

Metagenomics, gut microbiome, computational biology
Reposted by Suguru Nishijima
Great to see this finally published!

Metalog: curated and harmonised contextual data for global metagenomics samples

now out in @narjournal.bsky.social

academic.oup.com/nar/advance-...
Metalog: curated and harmonised contextual data for global metagenomics samples
Abstract. Metagenomic sequencing enables the in-depth study of microbes and their functions in humans, animals, and the environment. While sequencing data
academic.oup.com
October 31, 2025 at 3:16 PM
Reposted by Suguru Nishijima
Latitudinal diversity gradients (LDGs) are found across 🌱🐨🦠 but their underlying mechanisms remain unclear.

In this study, we highlight that LDGs are not universal in marine microbiomes but reflect lineage-specific ecological strategies and environmental responses.
doi.org/10.1101/2025...
Variations in the latitudinal diversity gradients of the ocean microbiome
Latitudinal diversity gradients (LDGs), typically declining from the equator to the poles, are among the most pervasive macroecological patterns, yet their generality and underlying drivers in the oce...
doi.org
October 15, 2025 at 12:05 PM
Reposted by Suguru Nishijima
My commentary article, featuring the work of Aasmets et al. on the long-lasting effects of medications on the gut microbiome, is now out in mSystems @asm.org
#microbiome #microsky

doi.org/10.1128/msys...
The gut remembers: the long-lasting effect of medication use on the gut microbiome | mSystems
Over the past decades, medication use has steadily increased worldwide, with individuals frequently taking multiple medications (polypharmacy), often repeatedly over extended periods of time (1). Yet,...
doi.org
September 23, 2025 at 5:33 AM
Reposted by Suguru Nishijima
Full thread will come later, but @annacusco.bsky.social's preprint on the dog pet gut microbiome is out!

Using ONT+Illumina, we get better MAGs than to corresponding species representative in public databases

doi.org/10.1101/2025...
September 18, 2025 at 12:01 PM
Reposted by Suguru Nishijima
We're very happy to release our new database Metalog metalog.embl.de ! It offers manually curated and harmonised contextual data for 110k metagenomics samples across the globe, incl. precomputed taxonomic profiles, for interactive browsing and for download 🧵 1/7

#microsky
Metalog
Metalog is a repository of manually annotated metadata (or contextual data) for metagenomic sequencing data from across the globe.
metalog.embl.de
August 15, 2025 at 8:07 AM
Reposted by Suguru Nishijima
Our new preprint is out!
www.biorxiv.org/content/10.1...
In this study, we present the largest systematic analysis of microbiome structure and function, integrating 85K uniformly processed metagenomes from diverse habitats worldwide.
@podlesny.bsky.social @jonas-bio.bsky.social @borklab.bsky.social
Planetary microbiome structure and generalist-driven gene flow across disparate habitats
Microbes are ubiquitous on Earth, forming microbiomes that sustain macroscopic life and biogeochemical cycles. Microbial dispersion, driven by natural processes and human activities, interconnects mic...
www.biorxiv.org
July 21, 2025 at 11:56 AM
Reposted by Suguru Nishijima
The team's first preprint is out!

Led by ‪
‪@vishnuprasoodanan.bsky.social‬‬ & @omaistrenko.bsky.social , we asked a question (almost) as old as microbiology: how many prokaryotic species exist on Earth? More specifically, how much diversity is "hiding" in existing metagenomic data?

A 🧵.
A census of hidden and discoverable microbial diversity beyond genome-centric approaches https://www.biorxiv.org/content/10.1101/2025.06.26.661807v1
June 27, 2025 at 8:10 PM
Reposted by Suguru Nishijima
📥 You have only until 24 June to submit your abstract for 'The human microbiome'❗

🔬💊 Explore cutting-edge breakthroughs in #microbiome research, from methodological innovations to integrative approaches and personalised therapeutics. Join #EESMicrobiome 🦠🔍

➡️ https://s.embl.org/ees25-08-bl
June 16, 2025 at 8:20 AM
Reposted by Suguru Nishijima
Interested in microbiome GWAS and heritability studies? Check out our new Review in Nature Reviews Genetics! We explore key findings, challenges, and future directions of the field.
rdcu.be/epoRR

@blekhman.bsky.social @sambhawa.bsky.social and Dr. Kelsey Johnson.
Genomics of host–microbiome interactions in humans
Nature Reviews Genetics - In this Review, Ferretti et al. discuss advances in our understanding of interactions between the human genome and the microbiome, including the effects of the microbiome...
rdcu.be
June 4, 2025 at 4:52 PM
I’m pleased to share that I've joined the Life Science Data Research Center at the University of Tokyo as a Project Associate Professor today! Excited to return to Japan and start this new chapter in Kashiwa! I look forward to continuing my research and new collaborations!
April 1, 2025 at 4:01 AM
Reposted by Suguru Nishijima
We're once again hosting the Human #Microbiome conference at @embl.org, organized by Ami Bhatt, Nicola Segata, Mani Arumugam and Peer Bork! We always have a great lineup of speakers, so register now and think about an abstract to submit (abstract submission deadline in June)
📣 Explore cutting-edge breakthroughs in microbiome research, from methodological innovations to integrative approaches and personalised therapeutics. Join #EESMicrobiome!🦠

📅 16 – 19 Sep 2025
📍 EMBL Heidelberg and Virtual
📥 Submit your abstract by 24 June

➡️ https://s.embl.org/ees25-08-bl
February 26, 2025 at 7:19 PM
Reposted by Suguru Nishijima
I’m excited to share our new paper published in Nature Communications!
In our work, we discovered TANB77, a bacterial clade previously obscured by a polyphyletic grouping in conventional taxonomy, as a reliable biomarker across diverse immunotherapy recipient groups.
www.nature.com/articles/s41...
A conserved pilin from uncultured gut bacterial clade TANB77 enhances cancer immunotherapy - Nature Communications
Here, the authors show that higher levels of the gut bacterial clade TANB77 associate with better response to cancer immunotherapy, and further demonstrate in mice that a conserved pilin from TANB77 p...
www.nature.com
December 28, 2024 at 1:57 PM
Reposted by Suguru Nishijima
It is my pleasure to invite you to the first Ukrainian School in Evolutionary Biology (USEB), which will take place in Uzhhorod University from January 27 to 31, 2025. The event is hybrid. Primary target audience is high school, undergraduate, Msc and Phd students, but everyone is welcome.
November 16, 2024 at 6:07 PM
Reposted by Suguru Nishijima
Excited to share our study led by @SakenovaNazgul! We used chemical genetics to identify and understand cross-resistance & collateral-sensitivity (CS) between antibiotics and reduced AMR development with CS drug pairs @embl.org with @camille_goemans @EPFL_en www.nature.com/articles/s41...
Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics - Nature Microbiology
Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. This study presents an approach to systematically discover and ...
www.nature.com
December 2, 2024 at 10:33 AM
Reposted by Suguru Nishijima
We're looking for a postdoc on the Computational Analysis of Environmental #Microbiome Data! www.embl.org/jobs/positio...
In the past two years, #EMBL scientists have gathered more than 3000 soil, sediment and water samples from Europe's coastlines within the #TREC expedition. (1/4)
EMBL Jobs
We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.
www.embl.org
November 7, 2024 at 9:24 AM
Reposted by Suguru Nishijima
Excited to see this out in Cell!
If you use microbiome data to look for disease associations, you might want to make sure microbial load is not confounding your results!
www.cell.com/cell/fulltex...
Congratulations @suguru-nishijima.bsky.social @borklab.bsky.social and others
#microsky #microbiome
Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations
A machine-learning approach enables the quantification of microbial load (microbial cells per gram) in fecal samples based on the relative microbiome profile. The predicted microbial load emerged as a...
www.cell.com
November 18, 2024 at 5:15 PM
Pleased to announce that our latest paper is published in Cell!
We developed a novel ML model that predicts fecal microbial load from relative species profiles, revealing it as a key factor shaping gut microbiome variation and disease-microbe associations
www.sciencedirect.com/science/arti...
Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations
The microbiota in individual habitats differ in both relative composition and absolute abundance. While sequencing approaches determine the relative a…
www.sciencedirect.com
November 14, 2024 at 6:01 AM
Excited to share our latest preprint on a novel computational tool to predict fecal microbial load solely from relative species profiles! Our study revealed that fecal microbial load is a substantial confounder in microbiome-disease association studies.
www.biorxiv.org/content/10.1...
March 19, 2024 at 11:41 AM