Sudarshan Rajagopal
@sudarrajagopal.bsky.social
Associate Professor of Medicine at Duke University School of Medicine. GPCR signaling and pulmonary vascular disease. Views my own.
Reposted by Sudarshan Rajagopal
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...
www.richmondscientific.com/how-a-discov...
How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific
A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.
www.richmondscientific.com
June 8, 2025 at 9:09 PM
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...
www.richmondscientific.com/how-a-discov...
Reposted by Sudarshan Rajagopal
NIH's work saves lives—& Trump is gutting it.
Straight from D.C. I headed to Seattle Children's to hear from researchers & patients alike about the importance of NIH funding—it's not just about lines in a budget, it's about lifesaving discoveries.
We ALL need to speak up to save it.
Straight from D.C. I headed to Seattle Children's to hear from researchers & patients alike about the importance of NIH funding—it's not just about lines in a budget, it's about lifesaving discoveries.
We ALL need to speak up to save it.
May 2, 2025 at 9:04 PM
NIH's work saves lives—& Trump is gutting it.
Straight from D.C. I headed to Seattle Children's to hear from researchers & patients alike about the importance of NIH funding—it's not just about lines in a budget, it's about lifesaving discoveries.
We ALL need to speak up to save it.
Straight from D.C. I headed to Seattle Children's to hear from researchers & patients alike about the importance of NIH funding—it's not just about lines in a budget, it's about lifesaving discoveries.
We ALL need to speak up to save it.
Excited to share work led by Preston Anderson and Peng Xiao in collaboration with Jinpeng Sun (just like old times when we were postdocs in Lefko lab). We find that beta-arrestins form biomolecular condensates to regulate GPCR function - www.biorxiv.org/content/10.1...
β-Arrestin Condensates Regulate G Protein-Coupled Receptor Function
G protein-coupled receptors (GPCRs) are the largest class of receptors in the genome and control many signaling cascades essential for survival. GPCR signaling is regulated by β-arrestins, multifuncti...
www.biorxiv.org
April 9, 2025 at 12:47 AM
Excited to share work led by Preston Anderson and Peng Xiao in collaboration with Jinpeng Sun (just like old times when we were postdocs in Lefko lab). We find that beta-arrestins form biomolecular condensates to regulate GPCR function - www.biorxiv.org/content/10.1...
Reposted by Sudarshan Rajagopal
Wow. This is really stunning . www.science.org/doi/10.1126/...
In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
www.science.org
March 21, 2025 at 6:02 PM
Wow. This is really stunning . www.science.org/doi/10.1126/...
Reposted by Sudarshan Rajagopal
NEW: NIH slashes overhead payments for research, sparking outrage | Science | AAAS www.science.org/content/arti...
NIH slashes overhead payments for research, sparking outrage
Move to cut indirect cost rate to 15% could cost universities billions of dollars
www.science.org
February 8, 2025 at 2:53 AM
NEW: NIH slashes overhead payments for research, sparking outrage | Science | AAAS www.science.org/content/arti...
Reposted by Sudarshan Rajagopal
'Speeds things up, you know. Move fast and break things, amIright?
Problem is, in biomedicine some of the things you break are human beings.'
@dereklowe.bsky.social
www.science.org/content/blog...
Problem is, in biomedicine some of the things you break are human beings.'
@dereklowe.bsky.social
www.science.org/content/blog...
Killing Cancer Patients (Once the Payments Clear)
www.science.org
February 2, 2025 at 11:12 AM
'Speeds things up, you know. Move fast and break things, amIright?
Problem is, in biomedicine some of the things you break are human beings.'
@dereklowe.bsky.social
www.science.org/content/blog...
Problem is, in biomedicine some of the things you break are human beings.'
@dereklowe.bsky.social
www.science.org/content/blog...
Reposted by Sudarshan Rajagopal
Merck stopped the Phase 3 Hyperion trial of its pulmonary arterial hypertension (PAH) treatment Winrevair early due to strong efficacy data & fiercepharma.com/pharma/effic... all study participants will be offered access to the drug. #biosky 1/n
January 30, 2025 at 10:51 PM
Merck stopped the Phase 3 Hyperion trial of its pulmonary arterial hypertension (PAH) treatment Winrevair early due to strong efficacy data & fiercepharma.com/pharma/effic... all study participants will be offered access to the drug. #biosky 1/n
Reposted by Sudarshan Rajagopal
American science and medicine has been thrown into chaos and uncertainty over the past week. Here are some stories to get up to speed. 1/12
January 28, 2025 at 3:58 AM
American science and medicine has been thrown into chaos and uncertainty over the past week. Here are some stories to get up to speed. 1/12
Reposted by Sudarshan Rajagopal
Started off this morning emailing my Senators and Congressman about the NIH and the potential damage being done by unnecessary disruptions.
They need to hear from us loud and clear. Constituents matter to them as one of the primary purposes of a politician is to get re-elected (and its their job).
They need to hear from us loud and clear. Constituents matter to them as one of the primary purposes of a politician is to get re-elected (and its their job).
January 23, 2025 at 11:26 AM
Started off this morning emailing my Senators and Congressman about the NIH and the potential damage being done by unnecessary disruptions.
They need to hear from us loud and clear. Constituents matter to them as one of the primary purposes of a politician is to get re-elected (and its their job).
They need to hear from us loud and clear. Constituents matter to them as one of the primary purposes of a politician is to get re-elected (and its their job).
Reposted by Sudarshan Rajagopal
Bluetorial: When the leadership of Science magazine does not seem to care about getting the facts right in a news story...
A very troubling incident occurred some years ago and I think the concerns and lessons are important.
My apologies for the length, but it is a complicated story.
A very troubling incident occurred some years ago and I think the concerns and lessons are important.
My apologies for the length, but it is a complicated story.
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
January 17, 2025 at 3:13 PM
Bluetorial: When the leadership of Science magazine does not seem to care about getting the facts right in a news story...
A very troubling incident occurred some years ago and I think the concerns and lessons are important.
My apologies for the length, but it is a complicated story.
A very troubling incident occurred some years ago and I think the concerns and lessons are important.
My apologies for the length, but it is a complicated story.
Reposted by Sudarshan Rajagopal
Can we design allosteric modulators that change a GPCR's preferred G protein? Yes!💥
BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.
The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209
🧵👇
BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.
The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209
🧵👇
Design of allosteric modulators that change GPCR G protein subtype selectivity
G protein-coupled receptors (GPCRs), the largest family of drug targets, can signal through 16 subtypes of Gα proteins. Biased compounds that selectively activate therapy-relevant pathways promise to ...
doi.org
November 22, 2024 at 4:09 PM
Can we design allosteric modulators that change a GPCR's preferred G protein? Yes!💥
BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.
The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209
🧵👇
BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.
The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209
🧵👇
Reposted by Sudarshan Rajagopal
We have updated and expanded our database of fellowships for POSTDOCS in neuroscience/neurology/cog science.
For each fellowship, we provide a description, $ amount, deadline, link, and eligibility criteria.
Download our database freely here: research.jhu.edu/rdt/funding-... pic.x.com/eEhXhlOzEj
For each fellowship, we provide a description, $ amount, deadline, link, and eligibility criteria.
Download our database freely here: research.jhu.edu/rdt/funding-... pic.x.com/eEhXhlOzEj
November 24, 2024 at 10:35 PM
We have updated and expanded our database of fellowships for POSTDOCS in neuroscience/neurology/cog science.
For each fellowship, we provide a description, $ amount, deadline, link, and eligibility criteria.
Download our database freely here: research.jhu.edu/rdt/funding-... pic.x.com/eEhXhlOzEj
For each fellowship, we provide a description, $ amount, deadline, link, and eligibility criteria.
Download our database freely here: research.jhu.edu/rdt/funding-... pic.x.com/eEhXhlOzEj