STEMCELL Science News
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A complete resource for the latest discoveries in cell biology, from organoids to immunology. Brought to you by STEMCELL Technologies.
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Science News by @stemcell.com offers 20 regular newsletters with the latest peer-reviewed research, reviews, and industry news delivered straight to your inbox.
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Science News by @stemcell.com offers 20 regular newsletters with the latest peer-reviewed research, reviews, and industry news delivered straight to your inbox.
💌 Subscribe here: https://bit.ly/47lRBjq
Drs. Wolfdieter Springer, Xu Hou, and @mayoclinic.org co-authors revealed complex interactions between #LewyBody pathology, neurofibrillary tangle pathology, and genetic mitophagy modifiers in Lewy body #Dementia brains. 🧠
📝 Check out the paper: https://bit.ly/3MfHUuU
📝 Check out the paper: https://bit.ly/3MfHUuU
December 3, 2025 at 11:07 PM
Drs. Wolfdieter Springer, Xu Hou, and @mayoclinic.org co-authors revealed complex interactions between #LewyBody pathology, neurofibrillary tangle pathology, and genetic mitophagy modifiers in Lewy body #Dementia brains. 🧠
📝 Check out the paper: https://bit.ly/3MfHUuU
📝 Check out the paper: https://bit.ly/3MfHUuU
🩸 Acute #leukemia is the most common type of cancer in children; however, the etiology is poorly understood.
This review summarizes the current evidence of the role of perinatal factors in the development of acute leukemia.
👉 https://bit.ly/4rxHsbc
This review summarizes the current evidence of the role of perinatal factors in the development of acute leukemia.
👉 https://bit.ly/4rxHsbc
December 3, 2025 at 6:13 PM
🩸 Acute #leukemia is the most common type of cancer in children; however, the etiology is poorly understood.
This review summarizes the current evidence of the role of perinatal factors in the development of acute leukemia.
👉 https://bit.ly/4rxHsbc
This review summarizes the current evidence of the role of perinatal factors in the development of acute leukemia.
👉 https://bit.ly/4rxHsbc
Among the five types of stem cells that have been experimentally applied to #LiverDisease, #MSCs have emerged as the most extensively studied, with the largest number of experimental and clinical research platforms worldwide.
📖 Read the review: https://bit.ly/48tNMYN
📖 Read the review: https://bit.ly/48tNMYN
December 2, 2025 at 10:14 PM
Among the five types of stem cells that have been experimentally applied to #LiverDisease, #MSCs have emerged as the most extensively studied, with the largest number of experimental and clinical research platforms worldwide.
📖 Read the review: https://bit.ly/48tNMYN
📖 Read the review: https://bit.ly/48tNMYN
💊 Researchers uncover a heme rheostat that is connected to gene expression and drug sensitivity in #AML and implicates heme biosynthesis enzyme inhibition as a trigger of cuproptosis.
🔗 https://bit.ly/4p6Wsvf
🔗 https://bit.ly/4p6Wsvf
December 2, 2025 at 5:07 PM
💊 Researchers uncover a heme rheostat that is connected to gene expression and drug sensitivity in #AML and implicates heme biosynthesis enzyme inhibition as a trigger of cuproptosis.
🔗 https://bit.ly/4p6Wsvf
🔗 https://bit.ly/4p6Wsvf
🧫 By leveraging lipid nanoparticles designed to selectively transfect tumor-associated #macrophages, scientists circumvent extensive ex vivo manipulation and achieve robust CAR expression directly within the tumor microenvironment.
👉 https://bit.ly/3KqyagG
👉 https://bit.ly/3KqyagG
December 2, 2025 at 12:55 AM
🧫 By leveraging lipid nanoparticles designed to selectively transfect tumor-associated #macrophages, scientists circumvent extensive ex vivo manipulation and achieve robust CAR expression directly within the tumor microenvironment.
👉 https://bit.ly/3KqyagG
👉 https://bit.ly/3KqyagG
A team of scientists from Air Force Medical University clarify how N-trans-feruloyloctopamine, as an FGF2 inhibitor, mitigates UVB-induced #SkinDamage and #hyperpigmentation by regulating this pathway.
💡Check it out: bit.ly/3KB67Lx
💡Check it out: bit.ly/3KB67Lx
December 2, 2025 at 12:20 AM
A team of scientists from Air Force Medical University clarify how N-trans-feruloyloctopamine, as an FGF2 inhibitor, mitigates UVB-induced #SkinDamage and #hyperpigmentation by regulating this pathway.
💡Check it out: bit.ly/3KB67Lx
💡Check it out: bit.ly/3KB67Lx
Liver cancer patients may soon be able to check if their disease has returned with a simple blood test that detects tumor-specific DNA changes in the bloodstream, as part of a new Curtain University-led research project.
📰 Check out the article: bit.ly/4ootZzU
📰 Check out the article: bit.ly/4ootZzU
November 29, 2025 at 2:02 AM
Liver cancer patients may soon be able to check if their disease has returned with a simple blood test that detects tumor-specific DNA changes in the bloodstream, as part of a new Curtain University-led research project.
📰 Check out the article: bit.ly/4ootZzU
📰 Check out the article: bit.ly/4ootZzU
A research team from Fudan University identify a subset of antibodies with broad-spectrum receptor-binding domain binding, including recognition of SARS-CoV-1 and emerging variants such as EG.5.1, BA.2.86, JN.1, and KP.2/3. 🦠
🔗 https://go.nature.com/3MoQQxO
🔗 https://go.nature.com/3MoQQxO
November 27, 2025 at 1:30 AM
A research team from Fudan University identify a subset of antibodies with broad-spectrum receptor-binding domain binding, including recognition of SARS-CoV-1 and emerging variants such as EG.5.1, BA.2.86, JN.1, and KP.2/3. 🦠
🔗 https://go.nature.com/3MoQQxO
🔗 https://go.nature.com/3MoQQxO
Researchers, including Drs. Sören Müller & Shannon Turley, show that Gremlin1-expressing lymph node fibroblastic reticular cells support #DendriticCell homeostasis via provision of Fms-like tyrosine kinase 3 ligand.
https://go.nature.com/3LZSV38
https://go.nature.com/3LZSV38
November 26, 2025 at 12:04 AM
Researchers, including Drs. Sören Müller & Shannon Turley, show that Gremlin1-expressing lymph node fibroblastic reticular cells support #DendriticCell homeostasis via provision of Fms-like tyrosine kinase 3 ligand.
https://go.nature.com/3LZSV38
https://go.nature.com/3LZSV38
Just published in @natcomms.nature.com! 🖨️
Dr. @LiorZangi and team used a targeted, non-viral modified mRNA system to transiently boost expression of pyruvate kinase muscle isozyme M2 in heart muscle cells of juvenile and adult pig models after ischemic injury.
https://go.nature.com/4rkC4bv
Dr. @LiorZangi and team used a targeted, non-viral modified mRNA system to transiently boost expression of pyruvate kinase muscle isozyme M2 in heart muscle cells of juvenile and adult pig models after ischemic injury.
https://go.nature.com/4rkC4bv
November 25, 2025 at 12:39 AM
Just published in @natcomms.nature.com! 🖨️
Dr. @LiorZangi and team used a targeted, non-viral modified mRNA system to transiently boost expression of pyruvate kinase muscle isozyme M2 in heart muscle cells of juvenile and adult pig models after ischemic injury.
https://go.nature.com/4rkC4bv
Dr. @LiorZangi and team used a targeted, non-viral modified mRNA system to transiently boost expression of pyruvate kinase muscle isozyme M2 in heart muscle cells of juvenile and adult pig models after ischemic injury.
https://go.nature.com/4rkC4bv
Reposted by STEMCELL Science News
Happy #MicroscopyMonday everyone!🔬 Today's image comes from Alice and it's a great fluorescent image of inner hair cells (stained with Phalloidin, magenta) from a 2-months old mutant.🐁 In this photo the expression of Baiap2l2 (green) was successfully restored with AAV-gene therapy.💉🧪
#NeuroSkyence
#NeuroSkyence
November 24, 2025 at 12:51 PM
Happy #MicroscopyMonday everyone!🔬 Today's image comes from Alice and it's a great fluorescent image of inner hair cells (stained with Phalloidin, magenta) from a 2-months old mutant.🐁 In this photo the expression of Baiap2l2 (green) was successfully restored with AAV-gene therapy.💉🧪
#NeuroSkyence
#NeuroSkyence
Ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) is a deubiquitinating enzyme involved in various cancers.
This study primarily investigates the expression, function, and mechanisms of UCHL3 in #GastricCancer.
👉 https://go.nature.com/43GtCJx
This study primarily investigates the expression, function, and mechanisms of UCHL3 in #GastricCancer.
👉 https://go.nature.com/43GtCJx
November 22, 2025 at 2:11 AM
Ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) is a deubiquitinating enzyme involved in various cancers.
This study primarily investigates the expression, function, and mechanisms of UCHL3 in #GastricCancer.
👉 https://go.nature.com/43GtCJx
This study primarily investigates the expression, function, and mechanisms of UCHL3 in #GastricCancer.
👉 https://go.nature.com/43GtCJx
🧪 Scientists from Fudan University identified ADK fusion genes as novel and recurrent drivers in hormone receptor-positive/human epidermal growth factor receptor 2-negative #BreastCancer.
https://go.nature.com/4pn42Bt
https://go.nature.com/4pn42Bt
November 21, 2025 at 12:50 AM
🧪 Scientists from Fudan University identified ADK fusion genes as novel and recurrent drivers in hormone receptor-positive/human epidermal growth factor receptor 2-negative #BreastCancer.
https://go.nature.com/4pn42Bt
https://go.nature.com/4pn42Bt
This review article delineates the mechanistic landscape by which resveratrol attenuates #glioblastoma (GBM) progression, with emphasis on #apoptosis induction, the promotion of differentiation, and the modulation of GBM stem-like cell phenotypes. 🧠
🔗 https://bit.ly/3XpWq5D
🔗 https://bit.ly/3XpWq5D
November 20, 2025 at 1:11 AM
This review article delineates the mechanistic landscape by which resveratrol attenuates #glioblastoma (GBM) progression, with emphasis on #apoptosis induction, the promotion of differentiation, and the modulation of GBM stem-like cell phenotypes. 🧠
🔗 https://bit.ly/3XpWq5D
🔗 https://bit.ly/3XpWq5D
New release from @natcellbio.nature.com!
Researchers led by @bloodgenes.bsky.social showed that HSC loss in existing culture methods is driven largely by ferroptosis and that it can be blocked to augment HSC expansion.
✅ go.nature.com/4ib4Ln6
Researchers led by @bloodgenes.bsky.social showed that HSC loss in existing culture methods is driven largely by ferroptosis and that it can be blocked to augment HSC expansion.
✅ go.nature.com/4ib4Ln6
November 19, 2025 at 10:25 PM
New release from @natcellbio.nature.com!
Researchers led by @bloodgenes.bsky.social showed that HSC loss in existing culture methods is driven largely by ferroptosis and that it can be blocked to augment HSC expansion.
✅ go.nature.com/4ib4Ln6
Researchers led by @bloodgenes.bsky.social showed that HSC loss in existing culture methods is driven largely by ferroptosis and that it can be blocked to augment HSC expansion.
✅ go.nature.com/4ib4Ln6
🤩🤩🤩
Always an exciting day when you get images like these ✨⭐️
November 19, 2025 at 10:22 PM
🤩🤩🤩
🥼 Two researchers from @uazcancercenter.bsky.social received $917,000 as part of a two-phase grant to investigate novel #immune-based approaches to prevent #keratinocytic skin cancers.
Congratulations! 👏
📰 Learn more: https://bit.ly/4o4IXL3
Congratulations! 👏
📰 Learn more: https://bit.ly/4o4IXL3
November 18, 2025 at 2:37 AM
🥼 Two researchers from @uazcancercenter.bsky.social received $917,000 as part of a two-phase grant to investigate novel #immune-based approaches to prevent #keratinocytic skin cancers.
Congratulations! 👏
📰 Learn more: https://bit.ly/4o4IXL3
Congratulations! 👏
📰 Learn more: https://bit.ly/4o4IXL3
Just in! 🔥
Scientists developed a hepatitis B surface antigen (HBsAg)-tagged tumor vaccine system, which leverages HBsAg-specific memory T cells from a HBsAg mRNA vaccine to target and lyse HBsAg-tagged tumor cells using the vaccinia virus.
https://go.nature.com/4pgiD1I
Scientists developed a hepatitis B surface antigen (HBsAg)-tagged tumor vaccine system, which leverages HBsAg-specific memory T cells from a HBsAg mRNA vaccine to target and lyse HBsAg-tagged tumor cells using the vaccinia virus.
https://go.nature.com/4pgiD1I
November 18, 2025 at 1:07 AM
Just in! 🔥
Scientists developed a hepatitis B surface antigen (HBsAg)-tagged tumor vaccine system, which leverages HBsAg-specific memory T cells from a HBsAg mRNA vaccine to target and lyse HBsAg-tagged tumor cells using the vaccinia virus.
https://go.nature.com/4pgiD1I
Scientists developed a hepatitis B surface antigen (HBsAg)-tagged tumor vaccine system, which leverages HBsAg-specific memory T cells from a HBsAg mRNA vaccine to target and lyse HBsAg-tagged tumor cells using the vaccinia virus.
https://go.nature.com/4pgiD1I
Researchers with Drs. Feng Qian and Lei Sun demonstrate the critical role of LMO7 in orchestrating tumor-associated macrophage (TAM) phagocytosis. 🥼
The expression of LMO7 in TAMs is associated with poor patient survival.
🔗 https://bit.ly/3LG4XOZ
The expression of LMO7 in TAMs is associated with poor patient survival.
🔗 https://bit.ly/3LG4XOZ
November 15, 2025 at 12:50 AM
Researchers with Drs. Feng Qian and Lei Sun demonstrate the critical role of LMO7 in orchestrating tumor-associated macrophage (TAM) phagocytosis. 🥼
The expression of LMO7 in TAMs is associated with poor patient survival.
🔗 https://bit.ly/3LG4XOZ
The expression of LMO7 in TAMs is associated with poor patient survival.
🔗 https://bit.ly/3LG4XOZ
⚗️ Researchers uncover the novel mechanistic insights in HCC recurrence after insufficient radiofrequency ablation, demonstrating the important role of heat stress-mediated tumor metabolism adaption by mRNA translation in HCC development.
👉 https://bit.ly/47SqX0A
👉 https://bit.ly/47SqX0A
November 14, 2025 at 11:58 PM
⚗️ Researchers uncover the novel mechanistic insights in HCC recurrence after insufficient radiofrequency ablation, demonstrating the important role of heat stress-mediated tumor metabolism adaption by mRNA translation in HCC development.
👉 https://bit.ly/47SqX0A
👉 https://bit.ly/47SqX0A
🫁 Investigators presented preclinical evidence of a safe and effective respiratory-delivered vaccine platform for inducing T cell-mediated sterilizing immunity against a respiratory pathogen.
@natmicrobiol.nature.com | go.nature.com/4p5zJiF
@natmicrobiol.nature.com | go.nature.com/4p5zJiF
November 13, 2025 at 1:16 AM
🫁 Investigators presented preclinical evidence of a safe and effective respiratory-delivered vaccine platform for inducing T cell-mediated sterilizing immunity against a respiratory pathogen.
@natmicrobiol.nature.com | go.nature.com/4p5zJiF
@natmicrobiol.nature.com | go.nature.com/4p5zJiF
🔎 Dr. Frank Grosveld and team investigated the role of three relatively poorly studied transcription factors in early embryonic hematopoietic development at single-cell resolution: Atf3, Zfp711 and Bcl6b.
bit.ly/49NHaqf
bit.ly/49NHaqf
November 13, 2025 at 1:11 AM
🔎 Dr. Frank Grosveld and team investigated the role of three relatively poorly studied transcription factors in early embryonic hematopoietic development at single-cell resolution: Atf3, Zfp711 and Bcl6b.
bit.ly/49NHaqf
bit.ly/49NHaqf
Scientists with Dr. Emeric Limagne uncover the role of the tumor-associated macrophage axis in inhibiting PD-L1 efficacy in microsatellite stable #ColorectalCancer.
📚 https://bit.ly/43q99Zn
📚 https://bit.ly/43q99Zn
November 11, 2025 at 5:07 PM
Scientists with Dr. Emeric Limagne uncover the role of the tumor-associated macrophage axis in inhibiting PD-L1 efficacy in microsatellite stable #ColorectalCancer.
📚 https://bit.ly/43q99Zn
📚 https://bit.ly/43q99Zn
Reposted by STEMCELL Science News
This image shows a mass of human stem cells, collectively known as an ‘organoid’.
We stained the neural crest cells of this organoid to better understand diseases related to defects in their development, such as Hirschsprung's disease and Neuroblastoma.
Image credit: @carmenmorenogon.bsky.social
We stained the neural crest cells of this organoid to better understand diseases related to defects in their development, such as Hirschsprung's disease and Neuroblastoma.
Image credit: @carmenmorenogon.bsky.social
November 10, 2025 at 9:27 AM
This image shows a mass of human stem cells, collectively known as an ‘organoid’.
We stained the neural crest cells of this organoid to better understand diseases related to defects in their development, such as Hirschsprung's disease and Neuroblastoma.
Image credit: @carmenmorenogon.bsky.social
We stained the neural crest cells of this organoid to better understand diseases related to defects in their development, such as Hirschsprung's disease and Neuroblastoma.
Image credit: @carmenmorenogon.bsky.social
Reposted by STEMCELL Science News
iPS cell-derived cardiac myocytes (heart muscle cells) typically beat about once per second, so I usually speed up the movies I post; otherwise, scrollers might miss the action. But every now and then, a cell looks like this in real time. #CellBiology
November 10, 2025 at 1:56 AM
iPS cell-derived cardiac myocytes (heart muscle cells) typically beat about once per second, so I usually speed up the movies I post; otherwise, scrollers might miss the action. But every now and then, a cell looks like this in real time. #CellBiology