STEMCELL Science News
@stemcellsciencenews.com
A complete resource for the latest discoveries in cell biology, from organoids to immunology. Brought to you by STEMCELL Technologies.
Drs. Wolfdieter Springer, Xu Hou, and @mayoclinic.org co-authors revealed complex interactions between #LewyBody pathology, neurofibrillary tangle pathology, and genetic mitophagy modifiers in Lewy body #Dementia brains. 🧠
📝 Check out the paper: https://bit.ly/3MfHUuU
📝 Check out the paper: https://bit.ly/3MfHUuU
December 3, 2025 at 11:07 PM
Drs. Wolfdieter Springer, Xu Hou, and @mayoclinic.org co-authors revealed complex interactions between #LewyBody pathology, neurofibrillary tangle pathology, and genetic mitophagy modifiers in Lewy body #Dementia brains. 🧠
📝 Check out the paper: https://bit.ly/3MfHUuU
📝 Check out the paper: https://bit.ly/3MfHUuU
🩸 Acute #leukemia is the most common type of cancer in children; however, the etiology is poorly understood.
This review summarizes the current evidence of the role of perinatal factors in the development of acute leukemia.
👉 https://bit.ly/4rxHsbc
This review summarizes the current evidence of the role of perinatal factors in the development of acute leukemia.
👉 https://bit.ly/4rxHsbc
December 3, 2025 at 6:13 PM
🩸 Acute #leukemia is the most common type of cancer in children; however, the etiology is poorly understood.
This review summarizes the current evidence of the role of perinatal factors in the development of acute leukemia.
👉 https://bit.ly/4rxHsbc
This review summarizes the current evidence of the role of perinatal factors in the development of acute leukemia.
👉 https://bit.ly/4rxHsbc
Among the five types of stem cells that have been experimentally applied to #LiverDisease, #MSCs have emerged as the most extensively studied, with the largest number of experimental and clinical research platforms worldwide.
📖 Read the review: https://bit.ly/48tNMYN
📖 Read the review: https://bit.ly/48tNMYN
December 2, 2025 at 10:14 PM
Among the five types of stem cells that have been experimentally applied to #LiverDisease, #MSCs have emerged as the most extensively studied, with the largest number of experimental and clinical research platforms worldwide.
📖 Read the review: https://bit.ly/48tNMYN
📖 Read the review: https://bit.ly/48tNMYN
💊 Researchers uncover a heme rheostat that is connected to gene expression and drug sensitivity in #AML and implicates heme biosynthesis enzyme inhibition as a trigger of cuproptosis.
🔗 https://bit.ly/4p6Wsvf
🔗 https://bit.ly/4p6Wsvf
December 2, 2025 at 5:07 PM
💊 Researchers uncover a heme rheostat that is connected to gene expression and drug sensitivity in #AML and implicates heme biosynthesis enzyme inhibition as a trigger of cuproptosis.
🔗 https://bit.ly/4p6Wsvf
🔗 https://bit.ly/4p6Wsvf
🧫 By leveraging lipid nanoparticles designed to selectively transfect tumor-associated #macrophages, scientists circumvent extensive ex vivo manipulation and achieve robust CAR expression directly within the tumor microenvironment.
👉 https://bit.ly/3KqyagG
👉 https://bit.ly/3KqyagG
December 2, 2025 at 12:55 AM
🧫 By leveraging lipid nanoparticles designed to selectively transfect tumor-associated #macrophages, scientists circumvent extensive ex vivo manipulation and achieve robust CAR expression directly within the tumor microenvironment.
👉 https://bit.ly/3KqyagG
👉 https://bit.ly/3KqyagG
A team of scientists from Air Force Medical University clarify how N-trans-feruloyloctopamine, as an FGF2 inhibitor, mitigates UVB-induced #SkinDamage and #hyperpigmentation by regulating this pathway.
💡Check it out: bit.ly/3KB67Lx
💡Check it out: bit.ly/3KB67Lx
December 2, 2025 at 12:20 AM
A team of scientists from Air Force Medical University clarify how N-trans-feruloyloctopamine, as an FGF2 inhibitor, mitigates UVB-induced #SkinDamage and #hyperpigmentation by regulating this pathway.
💡Check it out: bit.ly/3KB67Lx
💡Check it out: bit.ly/3KB67Lx
Liver cancer patients may soon be able to check if their disease has returned with a simple blood test that detects tumor-specific DNA changes in the bloodstream, as part of a new Curtain University-led research project.
📰 Check out the article: bit.ly/4ootZzU
📰 Check out the article: bit.ly/4ootZzU
November 29, 2025 at 2:02 AM
Liver cancer patients may soon be able to check if their disease has returned with a simple blood test that detects tumor-specific DNA changes in the bloodstream, as part of a new Curtain University-led research project.
📰 Check out the article: bit.ly/4ootZzU
📰 Check out the article: bit.ly/4ootZzU
A research team from Fudan University identify a subset of antibodies with broad-spectrum receptor-binding domain binding, including recognition of SARS-CoV-1 and emerging variants such as EG.5.1, BA.2.86, JN.1, and KP.2/3. 🦠
🔗 https://go.nature.com/3MoQQxO
🔗 https://go.nature.com/3MoQQxO
November 27, 2025 at 1:30 AM
A research team from Fudan University identify a subset of antibodies with broad-spectrum receptor-binding domain binding, including recognition of SARS-CoV-1 and emerging variants such as EG.5.1, BA.2.86, JN.1, and KP.2/3. 🦠
🔗 https://go.nature.com/3MoQQxO
🔗 https://go.nature.com/3MoQQxO
Researchers, including Drs. Sören Müller & Shannon Turley, show that Gremlin1-expressing lymph node fibroblastic reticular cells support #DendriticCell homeostasis via provision of Fms-like tyrosine kinase 3 ligand.
https://go.nature.com/3LZSV38
https://go.nature.com/3LZSV38
November 26, 2025 at 12:04 AM
Researchers, including Drs. Sören Müller & Shannon Turley, show that Gremlin1-expressing lymph node fibroblastic reticular cells support #DendriticCell homeostasis via provision of Fms-like tyrosine kinase 3 ligand.
https://go.nature.com/3LZSV38
https://go.nature.com/3LZSV38
Just published in @natcomms.nature.com! 🖨️
Dr. @LiorZangi and team used a targeted, non-viral modified mRNA system to transiently boost expression of pyruvate kinase muscle isozyme M2 in heart muscle cells of juvenile and adult pig models after ischemic injury.
https://go.nature.com/4rkC4bv
Dr. @LiorZangi and team used a targeted, non-viral modified mRNA system to transiently boost expression of pyruvate kinase muscle isozyme M2 in heart muscle cells of juvenile and adult pig models after ischemic injury.
https://go.nature.com/4rkC4bv
November 25, 2025 at 12:39 AM
Just published in @natcomms.nature.com! 🖨️
Dr. @LiorZangi and team used a targeted, non-viral modified mRNA system to transiently boost expression of pyruvate kinase muscle isozyme M2 in heart muscle cells of juvenile and adult pig models after ischemic injury.
https://go.nature.com/4rkC4bv
Dr. @LiorZangi and team used a targeted, non-viral modified mRNA system to transiently boost expression of pyruvate kinase muscle isozyme M2 in heart muscle cells of juvenile and adult pig models after ischemic injury.
https://go.nature.com/4rkC4bv
Ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) is a deubiquitinating enzyme involved in various cancers.
This study primarily investigates the expression, function, and mechanisms of UCHL3 in #GastricCancer.
👉 https://go.nature.com/43GtCJx
This study primarily investigates the expression, function, and mechanisms of UCHL3 in #GastricCancer.
👉 https://go.nature.com/43GtCJx
November 22, 2025 at 2:11 AM
Ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) is a deubiquitinating enzyme involved in various cancers.
This study primarily investigates the expression, function, and mechanisms of UCHL3 in #GastricCancer.
👉 https://go.nature.com/43GtCJx
This study primarily investigates the expression, function, and mechanisms of UCHL3 in #GastricCancer.
👉 https://go.nature.com/43GtCJx
🧪 Scientists from Fudan University identified ADK fusion genes as novel and recurrent drivers in hormone receptor-positive/human epidermal growth factor receptor 2-negative #BreastCancer.
https://go.nature.com/4pn42Bt
https://go.nature.com/4pn42Bt
November 21, 2025 at 12:50 AM
🧪 Scientists from Fudan University identified ADK fusion genes as novel and recurrent drivers in hormone receptor-positive/human epidermal growth factor receptor 2-negative #BreastCancer.
https://go.nature.com/4pn42Bt
https://go.nature.com/4pn42Bt
This review article delineates the mechanistic landscape by which resveratrol attenuates #glioblastoma (GBM) progression, with emphasis on #apoptosis induction, the promotion of differentiation, and the modulation of GBM stem-like cell phenotypes. 🧠
🔗 https://bit.ly/3XpWq5D
🔗 https://bit.ly/3XpWq5D
November 20, 2025 at 1:11 AM
This review article delineates the mechanistic landscape by which resveratrol attenuates #glioblastoma (GBM) progression, with emphasis on #apoptosis induction, the promotion of differentiation, and the modulation of GBM stem-like cell phenotypes. 🧠
🔗 https://bit.ly/3XpWq5D
🔗 https://bit.ly/3XpWq5D
New release from @natcellbio.nature.com!
Researchers led by @bloodgenes.bsky.social showed that HSC loss in existing culture methods is driven largely by ferroptosis and that it can be blocked to augment HSC expansion.
✅ go.nature.com/4ib4Ln6
Researchers led by @bloodgenes.bsky.social showed that HSC loss in existing culture methods is driven largely by ferroptosis and that it can be blocked to augment HSC expansion.
✅ go.nature.com/4ib4Ln6
November 19, 2025 at 10:25 PM
New release from @natcellbio.nature.com!
Researchers led by @bloodgenes.bsky.social showed that HSC loss in existing culture methods is driven largely by ferroptosis and that it can be blocked to augment HSC expansion.
✅ go.nature.com/4ib4Ln6
Researchers led by @bloodgenes.bsky.social showed that HSC loss in existing culture methods is driven largely by ferroptosis and that it can be blocked to augment HSC expansion.
✅ go.nature.com/4ib4Ln6
🥼 Two researchers from @uazcancercenter.bsky.social received $917,000 as part of a two-phase grant to investigate novel #immune-based approaches to prevent #keratinocytic skin cancers.
Congratulations! 👏
📰 Learn more: https://bit.ly/4o4IXL3
Congratulations! 👏
📰 Learn more: https://bit.ly/4o4IXL3
November 18, 2025 at 2:37 AM
🥼 Two researchers from @uazcancercenter.bsky.social received $917,000 as part of a two-phase grant to investigate novel #immune-based approaches to prevent #keratinocytic skin cancers.
Congratulations! 👏
📰 Learn more: https://bit.ly/4o4IXL3
Congratulations! 👏
📰 Learn more: https://bit.ly/4o4IXL3
Just in! 🔥
Scientists developed a hepatitis B surface antigen (HBsAg)-tagged tumor vaccine system, which leverages HBsAg-specific memory T cells from a HBsAg mRNA vaccine to target and lyse HBsAg-tagged tumor cells using the vaccinia virus.
https://go.nature.com/4pgiD1I
Scientists developed a hepatitis B surface antigen (HBsAg)-tagged tumor vaccine system, which leverages HBsAg-specific memory T cells from a HBsAg mRNA vaccine to target and lyse HBsAg-tagged tumor cells using the vaccinia virus.
https://go.nature.com/4pgiD1I
November 18, 2025 at 1:07 AM
Just in! 🔥
Scientists developed a hepatitis B surface antigen (HBsAg)-tagged tumor vaccine system, which leverages HBsAg-specific memory T cells from a HBsAg mRNA vaccine to target and lyse HBsAg-tagged tumor cells using the vaccinia virus.
https://go.nature.com/4pgiD1I
Scientists developed a hepatitis B surface antigen (HBsAg)-tagged tumor vaccine system, which leverages HBsAg-specific memory T cells from a HBsAg mRNA vaccine to target and lyse HBsAg-tagged tumor cells using the vaccinia virus.
https://go.nature.com/4pgiD1I
Researchers with Drs. Feng Qian and Lei Sun demonstrate the critical role of LMO7 in orchestrating tumor-associated macrophage (TAM) phagocytosis. 🥼
The expression of LMO7 in TAMs is associated with poor patient survival.
🔗 https://bit.ly/3LG4XOZ
The expression of LMO7 in TAMs is associated with poor patient survival.
🔗 https://bit.ly/3LG4XOZ
November 15, 2025 at 12:50 AM
Researchers with Drs. Feng Qian and Lei Sun demonstrate the critical role of LMO7 in orchestrating tumor-associated macrophage (TAM) phagocytosis. 🥼
The expression of LMO7 in TAMs is associated with poor patient survival.
🔗 https://bit.ly/3LG4XOZ
The expression of LMO7 in TAMs is associated with poor patient survival.
🔗 https://bit.ly/3LG4XOZ
⚗️ Researchers uncover the novel mechanistic insights in HCC recurrence after insufficient radiofrequency ablation, demonstrating the important role of heat stress-mediated tumor metabolism adaption by mRNA translation in HCC development.
👉 https://bit.ly/47SqX0A
👉 https://bit.ly/47SqX0A
November 14, 2025 at 11:58 PM
⚗️ Researchers uncover the novel mechanistic insights in HCC recurrence after insufficient radiofrequency ablation, demonstrating the important role of heat stress-mediated tumor metabolism adaption by mRNA translation in HCC development.
👉 https://bit.ly/47SqX0A
👉 https://bit.ly/47SqX0A
🫁 Investigators presented preclinical evidence of a safe and effective respiratory-delivered vaccine platform for inducing T cell-mediated sterilizing immunity against a respiratory pathogen.
@natmicrobiol.nature.com | go.nature.com/4p5zJiF
@natmicrobiol.nature.com | go.nature.com/4p5zJiF
November 13, 2025 at 1:16 AM
🫁 Investigators presented preclinical evidence of a safe and effective respiratory-delivered vaccine platform for inducing T cell-mediated sterilizing immunity against a respiratory pathogen.
@natmicrobiol.nature.com | go.nature.com/4p5zJiF
@natmicrobiol.nature.com | go.nature.com/4p5zJiF
🔎 Dr. Frank Grosveld and team investigated the role of three relatively poorly studied transcription factors in early embryonic hematopoietic development at single-cell resolution: Atf3, Zfp711 and Bcl6b.
bit.ly/49NHaqf
bit.ly/49NHaqf
November 13, 2025 at 1:11 AM
🔎 Dr. Frank Grosveld and team investigated the role of three relatively poorly studied transcription factors in early embryonic hematopoietic development at single-cell resolution: Atf3, Zfp711 and Bcl6b.
bit.ly/49NHaqf
bit.ly/49NHaqf
Scientists with Dr. Emeric Limagne uncover the role of the tumor-associated macrophage axis in inhibiting PD-L1 efficacy in microsatellite stable #ColorectalCancer.
📚 https://bit.ly/43q99Zn
📚 https://bit.ly/43q99Zn
November 11, 2025 at 5:07 PM
Scientists with Dr. Emeric Limagne uncover the role of the tumor-associated macrophage axis in inhibiting PD-L1 efficacy in microsatellite stable #ColorectalCancer.
📚 https://bit.ly/43q99Zn
📚 https://bit.ly/43q99Zn
Scientists integrated scRNA-seq of primary tumors and matched metastatic lymph nodes from six #GastricCancer patients to identify a metastatic epithelial subpopulation characterized by EGR4 overexpression.
🔎 Discover their results: https://go.nature.com/4qOFxPa
🔎 Discover their results: https://go.nature.com/4qOFxPa
November 7, 2025 at 9:59 PM
Scientists integrated scRNA-seq of primary tumors and matched metastatic lymph nodes from six #GastricCancer patients to identify a metastatic epithelial subpopulation characterized by EGR4 overexpression.
🔎 Discover their results: https://go.nature.com/4qOFxPa
🔎 Discover their results: https://go.nature.com/4qOFxPa
This review focus on several deubiquitinases associated with #BreastCancer, including their structure, function, and relationship to breast cancer.
💡Get the full story: bit.ly/3Xh9U3g
💡Get the full story: bit.ly/3Xh9U3g
November 7, 2025 at 1:54 AM
This review focus on several deubiquitinases associated with #BreastCancer, including their structure, function, and relationship to breast cancer.
💡Get the full story: bit.ly/3Xh9U3g
💡Get the full story: bit.ly/3Xh9U3g
Scientists generated human antral stomach #organoids from #hESCs. Their data suggest the feasibility of inducing gastric insulin-secreting cells in situ in the human stomach.
🔓 More here: https://bit.ly/492AJzq
🔓 More here: https://bit.ly/492AJzq
November 7, 2025 at 1:41 AM
Scientists generated human antral stomach #organoids from #hESCs. Their data suggest the feasibility of inducing gastric insulin-secreting cells in situ in the human stomach.
🔓 More here: https://bit.ly/492AJzq
🔓 More here: https://bit.ly/492AJzq
Colleagues at @alleninstitute.org , Drs. Velthoven and Zeng, led this study presenting the transcriptomic and spatial organization of telencephalic GABAergic neurons.
This enables a unified view of the molecular and anatomical organization of GABAergic neurons.
https://go.nature.com/4onOrBz
This enables a unified view of the molecular and anatomical organization of GABAergic neurons.
https://go.nature.com/4onOrBz
November 6, 2025 at 12:29 AM
Colleagues at @alleninstitute.org , Drs. Velthoven and Zeng, led this study presenting the transcriptomic and spatial organization of telencephalic GABAergic neurons.
This enables a unified view of the molecular and anatomical organization of GABAergic neurons.
https://go.nature.com/4onOrBz
This enables a unified view of the molecular and anatomical organization of GABAergic neurons.
https://go.nature.com/4onOrBz