Orjona Stella Taso
@stellataso.bsky.social
Post doc @UCL Keuss/Fratta labs
ALS research 🧠🧫👩🏻🔬
Gregory lab alumni: https://rb.gy/am1ocu
🏳️🌈🏳️⚧️ally (she/her)
ALS research 🧠🧫👩🏻🔬
Gregory lab alumni: https://rb.gy/am1ocu
🏳️🌈🏳️⚧️ally (she/her)
Reposted by Orjona Stella Taso
Happy holidays from my lab to yours - current/past/affiliate I’m super proud to work alongside these fantastic humans 🥳
December 16, 2025 at 6:26 PM
Happy holidays from my lab to yours - current/past/affiliate I’m super proud to work alongside these fantastic humans 🥳
Reposted by Orjona Stella Taso
On the first day of the MND Association ALS International Symposium in San Diego, we share Stella Taso's story of how receiving a Euan MacDonald Centre bursary to attend this conference & others, has helped her career⬇️
www.euanmacdonaldcentre.org/about/news/y...
@stellataso.bsky.social #alsmndsymp
www.euanmacdonaldcentre.org/about/news/y...
@stellataso.bsky.social #alsmndsymp
Your fundraising in action: supporting early career researchers to attend conferences | The Euan MacDonald Centre
www.euanmacdonaldcentre.org
December 5, 2025 at 9:20 AM
On the first day of the MND Association ALS International Symposium in San Diego, we share Stella Taso's story of how receiving a Euan MacDonald Centre bursary to attend this conference & others, has helped her career⬇️
www.euanmacdonaldcentre.org/about/news/y...
@stellataso.bsky.social #alsmndsymp
www.euanmacdonaldcentre.org/about/news/y...
@stellataso.bsky.social #alsmndsymp
Reposted by Orjona Stella Taso
Congratulations to Pete Harley on successfully being awarded a Wellcome Trust Early-Career Award - 'Uncovering the interplay of synaptic activity and TDP-43 pathology in neurodegeneration', starting in January 2026.
@peteharley95.bsky.social
@peteharley95.bsky.social
November 11, 2025 at 4:06 PM
Congratulations to Pete Harley on successfully being awarded a Wellcome Trust Early-Career Award - 'Uncovering the interplay of synaptic activity and TDP-43 pathology in neurodegeneration', starting in January 2026.
@peteharley95.bsky.social
@peteharley95.bsky.social
Reposted by Orjona Stella Taso
Look at these beautiful organoids grown by @sophie0g.bsky.social ! Who needs fireworks when we can look down the microscope at these stunners 😎
🔬 These images show forebrain organoids that are grown at the UCL Wray Lab to study dementia. This research focuses on a genetic form of frontotemporal dementia, and the colours confirm that the organoids have developing neurons (neural progenitors).
📸: Sophie Goldsmith, @uclqsion.bsky.social
📸: Sophie Goldsmith, @uclqsion.bsky.social
November 5, 2025 at 5:08 PM
Look at these beautiful organoids grown by @sophie0g.bsky.social ! Who needs fireworks when we can look down the microscope at these stunners 😎
Reposted by Orjona Stella Taso
It was a great honour to give the Keynote talk at the A*STAR IMCB Annual Retreat yesterday. It was a great evening full of exciting scientific discourse. I look forward to further interactions and collaborations between our Neurobiology Programme at NUS Life Sciences Institute and A*STAR IMCB!
October 18, 2025 at 6:19 AM
It was a great honour to give the Keynote talk at the A*STAR IMCB Annual Retreat yesterday. It was a great evening full of exciting scientific discourse. I look forward to further interactions and collaborations between our Neurobiology Programme at NUS Life Sciences Institute and A*STAR IMCB!
Reposted by Orjona Stella Taso
🧠New preprint: Neurodegeneration-associated proteinopathies are not confined to the brain, they can be detected in routine GI biopsies, years before symptom onset.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset
Background : Disease-modifying therapies for neurodegenerative disorders are unlikely to succeed once symptoms emerge, as significant neuronal loss has already occurred. Accessible biomarkers that pre...
www.medrxiv.org
October 16, 2025 at 9:07 AM
🧠New preprint: Neurodegeneration-associated proteinopathies are not confined to the brain, they can be detected in routine GI biopsies, years before symptom onset.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Orjona Stella Taso
Dear Friends and Colleagues, we are finally on Bluesky!
Our lab uses human stem cell models to understand brain, spinal cord and peripheral nerve diseases, focusing on RNA metabolism and cellular autonomy.
We are based at NUS in Singapore at the Life Sciences Institute: www.nus.edu.sg/lsi/
Our lab uses human stem cell models to understand brain, spinal cord and peripheral nerve diseases, focusing on RNA metabolism and cellular autonomy.
We are based at NUS in Singapore at the Life Sciences Institute: www.nus.edu.sg/lsi/
www.nus.edu.sg
September 28, 2025 at 10:57 AM
Dear Friends and Colleagues, we are finally on Bluesky!
Our lab uses human stem cell models to understand brain, spinal cord and peripheral nerve diseases, focusing on RNA metabolism and cellular autonomy.
We are based at NUS in Singapore at the Life Sciences Institute: www.nus.edu.sg/lsi/
Our lab uses human stem cell models to understand brain, spinal cord and peripheral nerve diseases, focusing on RNA metabolism and cellular autonomy.
We are based at NUS in Singapore at the Life Sciences Institute: www.nus.edu.sg/lsi/
Reposted by Orjona Stella Taso
Tomorrow at 12pm BST – Join Dr Kate Harris & Dr Dominic Trépel for our final Salon Educational Livestream of 2025 on organising your lab for focus, flexibility & success.
communities.dementiaresearcher.nihr.ac.uk/c/events/org...
communities.dementiaresearcher.nihr.ac.uk/c/events/org...
Dementia Researcher Salon - Organising your Lab for Maximum Efficiency
Dementia Researcher Salon - Organising your Lab for Maximum Efficiency
communities.dementiaresearcher.nihr.ac.uk
September 23, 2025 at 11:01 PM
Tomorrow at 12pm BST – Join Dr Kate Harris & Dr Dominic Trépel for our final Salon Educational Livestream of 2025 on organising your lab for focus, flexibility & success.
communities.dementiaresearcher.nihr.ac.uk/c/events/org...
communities.dementiaresearcher.nihr.ac.uk/c/events/org...
Reposted by Orjona Stella Taso
This was highly collaborative across 4 @asapresearch.parkinsonsroadmap.org teams, big thanks to all my amazing co-authors for their hard work!
September 12, 2025 at 1:17 PM
This was highly collaborative across 4 @asapresearch.parkinsonsroadmap.org teams, big thanks to all my amazing co-authors for their hard work!
Reposted by Orjona Stella Taso
Really excited to share our preprint on TDP-43 mis-splicing in #Parkinson’s disease. We found enrichment of genes and junctions affected by TDP-43 loss of function across the PD brain and models.
September 12, 2025 at 1:16 PM
Really excited to share our preprint on TDP-43 mis-splicing in #Parkinson’s disease. We found enrichment of genes and junctions affected by TDP-43 loss of function across the PD brain and models.
Reposted by Orjona Stella Taso
TDP-43 loss of function drives aberrant splicing in Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.09.04.673943v1
September 9, 2025 at 7:16 PM
TDP-43 loss of function drives aberrant splicing in Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.09.04.673943v1
Reposted by Orjona Stella Taso
📢BREAKING: Just left the courthouse for our NIH grant termination case
Judge ruled terminations are “VOID & ILLEGAL”
As a plaintiff, I felt a wave of relief & hope; he acknowledged the discrimination & harm
Closed by asking, ‘Have we fallen so low? Have we no shame?’
Judge ruled terminations are “VOID & ILLEGAL”
As a plaintiff, I felt a wave of relief & hope; he acknowledged the discrimination & harm
Closed by asking, ‘Have we fallen so low? Have we no shame?’
June 16, 2025 at 9:26 PM
📢BREAKING: Just left the courthouse for our NIH grant termination case
Judge ruled terminations are “VOID & ILLEGAL”
As a plaintiff, I felt a wave of relief & hope; he acknowledged the discrimination & harm
Closed by asking, ‘Have we fallen so low? Have we no shame?’
Judge ruled terminations are “VOID & ILLEGAL”
As a plaintiff, I felt a wave of relief & hope; he acknowledged the discrimination & harm
Closed by asking, ‘Have we fallen so low? Have we no shame?’
Reposted by Orjona Stella Taso
Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments.
Apply here👇
shorturl.at/LpCAq
Apply here👇
shorturl.at/LpCAq
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
shorturl.at
May 16, 2025 at 8:48 AM
Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments.
Apply here👇
shorturl.at/LpCAq
Apply here👇
shorturl.at/LpCAq
Reposted by Orjona Stella Taso
Out now: Our meeting report of the 2024 European Society of Toxicologic Pathology (ESTP) meeting session 'Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery'. doi.org/10.1177/0192...
Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery - Laura Fusaro, Dinesh S. Bangari, R. Jeroen Pasterkamp, Javier Fernández-Ruiz, Sameh A. Youssef, Alok ...
The fourth session of the 2024 European Society of Toxicologic Pathology (ESTP) Congress brought together lectures focused on the use of in vitro and in vivo mo...
doi.org
May 16, 2025 at 10:17 AM
Out now: Our meeting report of the 2024 European Society of Toxicologic Pathology (ESTP) meeting session 'Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery'. doi.org/10.1177/0192...
Reposted by Orjona Stella Taso
Excited to share a new preprint from our collaborative work led by Emil Gustavsson, Mina Ryten & @celarber.bsky.social - we used long read sequencing to identify novel APP transcripts that are competent to generate Abeta
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Independent Generation of Amyloid-β via Novel APP Transcripts
The amyloid precursor protein (APP) is processed by multiple enzymes to generate biologically active peptides, including amyloid-β (Aβ), which aggregates to form the hallmark pathology of Alzheimers d...
www.biorxiv.org
May 14, 2025 at 2:56 PM
Excited to share a new preprint from our collaborative work led by Emil Gustavsson, Mina Ryten & @celarber.bsky.social - we used long read sequencing to identify novel APP transcripts that are competent to generate Abeta
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Orjona Stella Taso
New research led by @marcaurelbusche.bsky.social has found that tau specifically disrupts a certain type of electrical activity in the hippocampus in Alzheimer's🧠
The findings unlock a key piece of the puzzle in understanding how toxic tau drives memory problems👏👉 buff.ly/yx8Rdk6
The findings unlock a key piece of the puzzle in understanding how toxic tau drives memory problems👏👉 buff.ly/yx8Rdk6
April 28, 2025 at 4:08 PM
New research led by @marcaurelbusche.bsky.social has found that tau specifically disrupts a certain type of electrical activity in the hippocampus in Alzheimer's🧠
The findings unlock a key piece of the puzzle in understanding how toxic tau drives memory problems👏👉 buff.ly/yx8Rdk6
The findings unlock a key piece of the puzzle in understanding how toxic tau drives memory problems👏👉 buff.ly/yx8Rdk6
Reposted by Orjona Stella Taso
Sums it up, thank you @theguardian.com for putting my unease into words
www.theguardian.com/commentisfre...
www.theguardian.com/commentisfre...
The Blue Origin flight showcased the utter defeat of American feminism | Moira Donegan
The trip leaned on a vision of women’s empowerment that is light on substance and heavy on a childlike, girlish silliness
www.theguardian.com
April 16, 2025 at 6:38 AM
Sums it up, thank you @theguardian.com for putting my unease into words
www.theguardian.com/commentisfre...
www.theguardian.com/commentisfre...
Reposted by Orjona Stella Taso
🚨 NEW PAPER: must-read for researchers, funders & institutions 🚨
👩🔬 >50% of female dementia researchers experience sexism in their careers.
🏫 5x more respondents found their institution NOT helpful than helpful in addressing this.
➡️ Learn more: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
👩🔬 >50% of female dementia researchers experience sexism in their careers.
🏫 5x more respondents found their institution NOT helpful than helpful in addressing this.
➡️ Learn more: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Experiences and perceptions of sexism in dementia research careers: A global cross‐sectional survey
INTRODUCTION
Sexism is prevalent in academia and is a crucial factor driving women out of the academic workforce. However, sexism in dementia research remains underexplored. This study aimed to unde.....
alz-journals.onlinelibrary.wiley.com
April 13, 2025 at 4:43 PM
🚨 NEW PAPER: must-read for researchers, funders & institutions 🚨
👩🔬 >50% of female dementia researchers experience sexism in their careers.
🏫 5x more respondents found their institution NOT helpful than helpful in addressing this.
➡️ Learn more: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
👩🔬 >50% of female dementia researchers experience sexism in their careers.
🏫 5x more respondents found their institution NOT helpful than helpful in addressing this.
➡️ Learn more: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Orjona Stella Taso
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.
April 10, 2025 at 1:38 PM
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.
Reposted by Orjona Stella Taso
I also had a chance to speak with HRH The Duchess of Edinburgh about our work using flies in dementia research. Everybody loves the flies. 😇😅🥰
April 1, 2025 at 12:30 PM
I also had a chance to speak with HRH The Duchess of Edinburgh about our work using flies in dementia research. Everybody loves the flies. 😇😅🥰
Reposted by Orjona Stella Taso
Many congratulations to Dr Bjorn Vahsen, who has been awarded the Junior Research Prize by Deutche Gesellschaft fur Muskelkranke e.V (The German Society for Muscular Diseases). @bvahsen.bsky.social @kavlioxford.bsky.social
Read more:
Read more:
Dr Bjorn Vahsen wins Junior Research Prize
The prize is awarded by the German Society of Muscular Diseases.
buff.ly
March 21, 2025 at 12:00 PM
Many congratulations to Dr Bjorn Vahsen, who has been awarded the Junior Research Prize by Deutche Gesellschaft fur Muskelkranke e.V (The German Society for Muscular Diseases). @bvahsen.bsky.social @kavlioxford.bsky.social
Read more:
Read more:
Reposted by Orjona Stella Taso
Congratulations to @bvahsen.bsky.social on receiving the German Society for Muscular Diseases Junior Research Prize for his work on microglia in #C9orf72 #ALS! ⭐ Read more about his work here: www.nature.com/articles/s41...
March 21, 2025 at 12:48 PM
Congratulations to @bvahsen.bsky.social on receiving the German Society for Muscular Diseases Junior Research Prize for his work on microglia in #C9orf72 #ALS! ⭐ Read more about his work here: www.nature.com/articles/s41...
Reposted by Orjona Stella Taso
Last week, CRN members met in Phoenix, Arizona for ASAP's 2025 CRN Collaborative Meeting 🥳
It was full of collaboration and enlightening conversations. Thank you to all who attended and made this meeting a success!
Learn more about the CRN here: bit.ly/41MnIod
#ParkinsonsResearch
It was full of collaboration and enlightening conversations. Thank you to all who attended and made this meeting a success!
Learn more about the CRN here: bit.ly/41MnIod
#ParkinsonsResearch
March 18, 2025 at 3:45 PM
Last week, CRN members met in Phoenix, Arizona for ASAP's 2025 CRN Collaborative Meeting 🥳
It was full of collaboration and enlightening conversations. Thank you to all who attended and made this meeting a success!
Learn more about the CRN here: bit.ly/41MnIod
#ParkinsonsResearch
It was full of collaboration and enlightening conversations. Thank you to all who attended and made this meeting a success!
Learn more about the CRN here: bit.ly/41MnIod
#ParkinsonsResearch
Reposted by Orjona Stella Taso
www.biorxiv.org/content/10.1... New work from Humphrey and Raj labs, exploring the role of RNA editing in myeloid cells. Hopefully will be a useful resource for the field. Next stop: genetics!
Cytosine-to-uracil RNA editing is upregulated by pro-inflammatory stimulation of myeloid cells
Myeloid cells undergo large changes to their gene expression profile in response to inflammatory stimulation. This includes an increase in post-transcriptional modifications carried out by adenosine-t...
www.biorxiv.org
March 17, 2025 at 8:46 PM
www.biorxiv.org/content/10.1... New work from Humphrey and Raj labs, exploring the role of RNA editing in myeloid cells. Hopefully will be a useful resource for the field. Next stop: genetics!