Barun Pradhan
@staggeredends.bsky.social
🧬 Interested in how Transposable Elements modulate (epi)gene/transcriptome🧪 Postdoc at Faulkner Lab at Mater Research Institute, Brisbane | Alumnus at Landau Lab (Weill Cornell Medicine, New York) and Kauppi Lab (Uni of Helsinki, Finland)
Very excited to share my Phd/early post-doc work, out now in Cancer Research! Using multiomic data from multi-site tumors from ovarian cancer patients, we show that the tumors continue to acquire LINE-1 insertions after metastatic spread and find determinants of LINE-1 permissivity in this disease.
Dynamic and Ongoing De Novo L1 Retrotransposition Contributes to Genome Plasticity and Intrapatient Heterogeneity in Ovarian Cancer
Abstract. L1 retrotransposons are the only protein-coding active transposable elements in the human genome. While typically silenced in normal cells, they are highly expressed in many human epithelial...
aacrjournals.org
November 20, 2025 at 10:54 PM
Very excited to share my Phd/early post-doc work, out now in Cancer Research! Using multiomic data from multi-site tumors from ovarian cancer patients, we show that the tumors continue to acquire LINE-1 insertions after metastatic spread and find determinants of LINE-1 permissivity in this disease.
Reposted by Barun Pradhan
🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
October 9, 2025 at 5:33 AM
🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Reposted by Barun Pradhan
If you haven't seen the news yet, the government of Nepal and the prime minister of Nepal murdered over 19 kids, some in school uniforms, and a kid that was 8 years old...just because they were protesting against their corruption and incompetence! #KPOli #Nepal www.reuters.com/business/med...
Nineteen killed in Nepal in 'Gen Z' protest over social media ban, corruption
At least 19 people in two cities died on Monday in Nepal's worst unrest in decades, authorities said, as police in the capital fired tear gas and rubber bullets at protesters trying to storm parliament in anger at a social media shutdown and corruption.
www.reuters.com
September 8, 2025 at 7:59 PM
If you haven't seen the news yet, the government of Nepal and the prime minister of Nepal murdered over 19 kids, some in school uniforms, and a kid that was 8 years old...just because they were protesting against their corruption and incompetence! #KPOli #Nepal www.reuters.com/business/med...
Reposted by Barun Pradhan
Highly accurate sequencing OR high throughput? We refuse to choose.
Introducing ppmSeq, a method built to deliver both. Our latest from the @landau.bsky.social lab with Ultima Genomics
👀👀👀
See ⬇️ for a primer on the next frontier of genomics
www.biorxiv.org/content/10.1...
Introducing ppmSeq, a method built to deliver both. Our latest from the @landau.bsky.social lab with Ultima Genomics
👀👀👀
See ⬇️ for a primer on the next frontier of genomics
www.biorxiv.org/content/10.1...
Paired plus-minus sequencing is an ultra-high throughput and accurate method for dual strand sequencing of DNA molecules
Distinguishing real biological variation in the form of single-nucleotide variants (SNVs) from errors is a major challenge for genome sequencing technologies. This is particularly true in settings whe...
www.biorxiv.org
August 14, 2025 at 5:41 PM
Highly accurate sequencing OR high throughput? We refuse to choose.
Introducing ppmSeq, a method built to deliver both. Our latest from the @landau.bsky.social lab with Ultima Genomics
👀👀👀
See ⬇️ for a primer on the next frontier of genomics
www.biorxiv.org/content/10.1...
Introducing ppmSeq, a method built to deliver both. Our latest from the @landau.bsky.social lab with Ultima Genomics
👀👀👀
See ⬇️ for a primer on the next frontier of genomics
www.biorxiv.org/content/10.1...
Reposted by Barun Pradhan
What happens when sequencing costs go ⏬ ?
Imagination and new opportunities go ⏫
@landau.bsky.social
Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the
@UltimaGenomics
platform 🧵👇
Lets goooo!!
rdcu.be/ehkUb
Imagination and new opportunities go ⏫
@landau.bsky.social
Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the
@UltimaGenomics
platform 🧵👇
Lets goooo!!
rdcu.be/ehkUb
Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling
Nature Methods - This work integrates duplex sequencing with cost-effective Ultima sequencing to enhance the accuracy of whole-genome circulating cell-free DNA profiling.
rdcu.be
April 11, 2025 at 3:53 PM
What happens when sequencing costs go ⏬ ?
Imagination and new opportunities go ⏫
@landau.bsky.social
Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the
@UltimaGenomics
platform 🧵👇
Lets goooo!!
rdcu.be/ehkUb
Imagination and new opportunities go ⏫
@landau.bsky.social
Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the
@UltimaGenomics
platform 🧵👇
Lets goooo!!
rdcu.be/ehkUb
Reposted by Barun Pradhan
I'm looking for a postdoc to join my fantastic team at the NIH in Bethesda, MD. Great resources. Competitive salary. www.training.nih.gov/jobs/pdf-mb-...
Postdoc: Molecular Biology/Genetics/Developmental Biology/Evolution/Computational Biology
www.training.nih.gov
January 8, 2025 at 7:06 PM
I'm looking for a postdoc to join my fantastic team at the NIH in Bethesda, MD. Great resources. Competitive salary. www.training.nih.gov/jobs/pdf-mb-...
Reposted by Barun Pradhan
🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics
Single-cell mapping of regulatory DNA:Protein interactions
Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibil...
biorxiv.org
January 2, 2025 at 9:10 PM
🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics
Reposted by Barun Pradhan
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Regulation of human interferon signaling by transposon exonization
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.
www.cell.com
December 12, 2024 at 6:57 PM
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Reposted by Barun Pradhan
🧬 🧠 Excited to see it printed! We bring key insights on the epigenetic regulation of SVAs, including SVA-XDP: a polymorphic SVA driving a rare neurodegenerative disorder
@jakobssonlab.bsky.social @vivienhorvath.bsky.social
#TEworldwide #Transposons #XDP #NSMB
+ the volume has the cutest cover 🦔
@jakobssonlab.bsky.social @vivienhorvath.bsky.social
#TEworldwide #Transposons #XDP #NSMB
+ the volume has the cutest cover 🦔
November 27, 2024 at 4:58 PM
🧬 🧠 Excited to see it printed! We bring key insights on the epigenetic regulation of SVAs, including SVA-XDP: a polymorphic SVA driving a rare neurodegenerative disorder
@jakobssonlab.bsky.social @vivienhorvath.bsky.social
#TEworldwide #Transposons #XDP #NSMB
+ the volume has the cutest cover 🦔
@jakobssonlab.bsky.social @vivienhorvath.bsky.social
#TEworldwide #Transposons #XDP #NSMB
+ the volume has the cutest cover 🦔
Excited to share this new publication where we did a comprehensive analysis of standard (short-read) 10x single-cell RNAseq data to show that the locus-specific expression of LINE-1s can be detected based on the transcriptional readthrough. rdcu.be/dzrSl
February 23, 2024 at 3:58 PM
Excited to share this new publication where we did a comprehensive analysis of standard (short-read) 10x single-cell RNAseq data to show that the locus-specific expression of LINE-1s can be detected based on the transcriptional readthrough. rdcu.be/dzrSl