Konstantin Sparrer
@sparrerlab.bsky.social
Neurovirology and Neuroinflammation @DZNE @uni_Ulm.
https://www.dzne.de/en/research/research-areas/fundamental-research/research-groups/sparrer/research-areas-focus/
https://www.dzne.de/en/research/research-areas/fundamental-research/research-groups/sparrer/research-areas-focus/
Reposted by Konstantin Sparrer
Highly recommended for late PhDs and Postdocs👇 #LoveVirology
ViroCareer Compass – Navigating Your Career in Virology
Shape your career at the 6th #ACHIEVE Workshop of the #GfV! Explore academia, industry & diagnostics, strengthen your CV, get hands-on tips for your first grant
📅 16–17 Mar 2026 | Heidelberg | Late PhD, postdocs & MDs
📝 Apply: achieve.g-f-v.org
Shape your career at the 6th #ACHIEVE Workshop of the #GfV! Explore academia, industry & diagnostics, strengthen your CV, get hands-on tips for your first grant
📅 16–17 Mar 2026 | Heidelberg | Late PhD, postdocs & MDs
📝 Apply: achieve.g-f-v.org
Arbeitskreis Achieve | Arbeitskreis der Gesellschaft für Virologie
achieve.g-f-v.org
November 21, 2025 at 12:44 PM
Highly recommended for late PhDs and Postdocs👇 #LoveVirology
Reposted by Konstantin Sparrer
The 2026 edition of the ACHIEVE mentoring program open to final year PhD students, postdoctoral researchers, and veterinary/medical doctors has just launched. You will benefit from 1-year individual mentoring by established PIs,
1/2
1/2
November 7, 2025 at 10:26 AM
The 2026 edition of the ACHIEVE mentoring program open to final year PhD students, postdoctoral researchers, and veterinary/medical doctors has just launched. You will benefit from 1-year individual mentoring by established PIs,
1/2
1/2
Reposted by Konstantin Sparrer
ViroCareer Compass – Navigating Your Career in Virology
Shape your career at the 6th #ACHIEVE Workshop of the #GfV! Explore academia, industry & diagnostics, strengthen your CV, get hands-on tips for your first grant
📅 16–17 Mar 2026 | Heidelberg | Late PhD, postdocs & MDs
📝 Apply: achieve.g-f-v.org
Shape your career at the 6th #ACHIEVE Workshop of the #GfV! Explore academia, industry & diagnostics, strengthen your CV, get hands-on tips for your first grant
📅 16–17 Mar 2026 | Heidelberg | Late PhD, postdocs & MDs
📝 Apply: achieve.g-f-v.org
Arbeitskreis Achieve | Arbeitskreis der Gesellschaft für Virologie
achieve.g-f-v.org
November 20, 2025 at 2:19 PM
ViroCareer Compass – Navigating Your Career in Virology
Shape your career at the 6th #ACHIEVE Workshop of the #GfV! Explore academia, industry & diagnostics, strengthen your CV, get hands-on tips for your first grant
📅 16–17 Mar 2026 | Heidelberg | Late PhD, postdocs & MDs
📝 Apply: achieve.g-f-v.org
Shape your career at the 6th #ACHIEVE Workshop of the #GfV! Explore academia, industry & diagnostics, strengthen your CV, get hands-on tips for your first grant
📅 16–17 Mar 2026 | Heidelberg | Late PhD, postdocs & MDs
📝 Apply: achieve.g-f-v.org
Reposted by Konstantin Sparrer
🔬 Upcoming Expert Insights Seminar by ACHIEVE
Join us on November 4th, 2025, at 2:00 PM (CET) for an inspiring talk on “BSL-4” by PD Dr. Thomas Hoenen. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Join us on November 4th, 2025, at 2:00 PM (CET) for an inspiring talk on “BSL-4” by PD Dr. Thomas Hoenen. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
October 29, 2025 at 8:39 AM
🔬 Upcoming Expert Insights Seminar by ACHIEVE
Join us on November 4th, 2025, at 2:00 PM (CET) for an inspiring talk on “BSL-4” by PD Dr. Thomas Hoenen. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Join us on November 4th, 2025, at 2:00 PM (CET) for an inspiring talk on “BSL-4” by PD Dr. Thomas Hoenen. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Reposted by Konstantin Sparrer
Let me be very clear. It is not enough that RFK Jr. was forced to admit today that no causal relationship between Tylenol and autism has been shown.
We know that while disinformation spreads like wildfire on social media, corrections most often die on the vine.
We know that while disinformation spreads like wildfire on social media, corrections most often die on the vine.
October 29, 2025 at 7:01 PM
Let me be very clear. It is not enough that RFK Jr. was forced to admit today that no causal relationship between Tylenol and autism has been shown.
We know that while disinformation spreads like wildfire on social media, corrections most often die on the vine.
We know that while disinformation spreads like wildfire on social media, corrections most often die on the vine.
Reposted by Konstantin Sparrer
🚨 The #HIRI invites applications for 2 JUNIOR GROUP LEADER POSITIONS in the areas of:
🔵 RNA Biology
🔵 RNA Medicine
🔵 RNA Technology
Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/6)
🔵 RNA Biology
🔵 RNA Medicine
🔵 RNA Technology
Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/6)
E15 Groups
The Helmholtz Institute for RNA-based Infection Researchopens a call for
www.helmholtz-hiri.de
October 28, 2025 at 4:04 PM
🚨 The #HIRI invites applications for 2 JUNIOR GROUP LEADER POSITIONS in the areas of:
🔵 RNA Biology
🔵 RNA Medicine
🔵 RNA Technology
Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/6)
🔵 RNA Biology
🔵 RNA Medicine
🔵 RNA Technology
Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/6)
Reposted by Konstantin Sparrer
Respiratory viruses activate autophagy via the IFN-STAT1/STAT5B-SOCS1 axis https://www.biorxiv.org/content/10.1101/2025.10.28.685013v1
October 29, 2025 at 4:17 AM
Respiratory viruses activate autophagy via the IFN-STAT1/STAT5B-SOCS1 axis https://www.biorxiv.org/content/10.1101/2025.10.28.685013v1
Reposted by Konstantin Sparrer
🔬 Upcoming Expert Insights Seminar by ACHIEVE
Join us on October 7th, 2025, at 2:00 PM (CET) for an inspiring talk on “AlphaFold & HerpesFolds” by Dr. Timothy Soh. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Join us on October 7th, 2025, at 2:00 PM (CET) for an inspiring talk on “AlphaFold & HerpesFolds” by Dr. Timothy Soh. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
October 1, 2025 at 7:08 AM
🔬 Upcoming Expert Insights Seminar by ACHIEVE
Join us on October 7th, 2025, at 2:00 PM (CET) for an inspiring talk on “AlphaFold & HerpesFolds” by Dr. Timothy Soh. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Join us on October 7th, 2025, at 2:00 PM (CET) for an inspiring talk on “AlphaFold & HerpesFolds” by Dr. Timothy Soh. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Reposted by Konstantin Sparrer
🦠 Abstract submission for the 35th Annual Meeting of the Society for Virology is open!
Share your research with the virology community and help shape the scientific dialogue next year in Heidelberg.
🕐 Deadline: Jan 4, 2026
🔗 virology-meeting.de/programme-ab...
#GfV2026 #virology #virologymeeting
Share your research with the virology community and help shape the scientific dialogue next year in Heidelberg.
🕐 Deadline: Jan 4, 2026
🔗 virology-meeting.de/programme-ab...
#GfV2026 #virology #virologymeeting
Abstract submission
virology-meeting.de
October 22, 2025 at 7:34 AM
🦠 Abstract submission for the 35th Annual Meeting of the Society for Virology is open!
Share your research with the virology community and help shape the scientific dialogue next year in Heidelberg.
🕐 Deadline: Jan 4, 2026
🔗 virology-meeting.de/programme-ab...
#GfV2026 #virology #virologymeeting
Share your research with the virology community and help shape the scientific dialogue next year in Heidelberg.
🕐 Deadline: Jan 4, 2026
🔗 virology-meeting.de/programme-ab...
#GfV2026 #virology #virologymeeting
Reposted by Konstantin Sparrer
Excited to be co-organizing this @embo.org Workshop on #Pathogen #Immunity and #Signalling next June 8-12 2026 in Leiden! 🥳🥳🥳 #Savethedate
Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...
October 18, 2025 at 5:05 PM
Excited to be co-organizing this @embo.org Workshop on #Pathogen #Immunity and #Signalling next June 8-12 2026 in Leiden! 🥳🥳🥳 #Savethedate
Reposted by Konstantin Sparrer
Nach einem Zoster (Gürtelrose) besteht ein erhöhtes Risiko für Demenz.
Die Impfung gegen Zoster verringert das Demenzrisiko signifikant.
Die Shingrix-Impfung ist für alle ab 60 Jahre und ab 50 Jahre mit Begleiterkrankungen empfohlen.
Die Impfung gegen Zoster verringert das Demenzrisiko signifikant.
Die Shingrix-Impfung ist für alle ab 60 Jahre und ab 50 Jahre mit Begleiterkrankungen empfohlen.
October 14, 2025 at 8:06 PM
Nach einem Zoster (Gürtelrose) besteht ein erhöhtes Risiko für Demenz.
Die Impfung gegen Zoster verringert das Demenzrisiko signifikant.
Die Shingrix-Impfung ist für alle ab 60 Jahre und ab 50 Jahre mit Begleiterkrankungen empfohlen.
Die Impfung gegen Zoster verringert das Demenzrisiko signifikant.
Die Shingrix-Impfung ist für alle ab 60 Jahre und ab 50 Jahre mit Begleiterkrankungen empfohlen.
Reposted by Konstantin Sparrer
🎉 Exciting news: my PhD project @daothilab.bsky.social has been published in #PLoS Pathogens! I investigated how the #hepatitis E virus ORF2 protein counteracts antiviral responses, contributing to persistent viral replication. A huge thank you to all collaborators! 🙏🏻
🔗 share.google/WwIT43Su3KOP...
🔗 share.google/WwIT43Su3KOP...
The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistent replication in cell culture
Author summary Hepatitis E virus (HEV) is an important yet often underestimated pathogen. Depending on the genotype, HEV infections can progress to chronicity, but the underlying mechanisms remain poo...
share.google
October 8, 2025 at 6:31 AM
🎉 Exciting news: my PhD project @daothilab.bsky.social has been published in #PLoS Pathogens! I investigated how the #hepatitis E virus ORF2 protein counteracts antiviral responses, contributing to persistent viral replication. A huge thank you to all collaborators! 🙏🏻
🔗 share.google/WwIT43Su3KOP...
🔗 share.google/WwIT43Su3KOP...
Reposted by Konstantin Sparrer
Historically, viruses were thought to primarily use host cell's translational machinery. New work from @harvardcellbio.bsky.social faculty Amy Lee reveals that a giant DNA virus encodes its own IF4F initiation complex, suggesting an unexpected evolutionary innovation. www.biorxiv.org/content/10.1...
Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life
In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...
www.biorxiv.org
October 2, 2025 at 6:10 PM
Historically, viruses were thought to primarily use host cell's translational machinery. New work from @harvardcellbio.bsky.social faculty Amy Lee reveals that a giant DNA virus encodes its own IF4F initiation complex, suggesting an unexpected evolutionary innovation. www.biorxiv.org/content/10.1...
Reposted by Konstantin Sparrer
Full room at the start of the 2nd Immunobiology symposium on pattern recognition receptors!
Looking forward to the great programme that we lined up for you together with @brozlab.bsky.social @martinon.bsky.social
#ImmunoSky
Looking forward to the great programme that we lined up for you together with @brozlab.bsky.social @martinon.bsky.social
#ImmunoSky
October 1, 2025 at 7:51 AM
Full room at the start of the 2nd Immunobiology symposium on pattern recognition receptors!
Looking forward to the great programme that we lined up for you together with @brozlab.bsky.social @martinon.bsky.social
#ImmunoSky
Looking forward to the great programme that we lined up for you together with @brozlab.bsky.social @martinon.bsky.social
#ImmunoSky
Reposted by Konstantin Sparrer
Feeling deeply honored to receive this year's Aventis Life Science Bridge Award. Grateful to the Aventis Foundation for their support, and to my colleagues, mentors, collaborators, and my amazing research team who make this work possible. Excited to keep pushing our HIV research forward together.
This year's “Life Sciences Bridge Award ” goes to Dr. Judith Feucht, Dr. Frauke Mücksch and Dr. Varun Venkataramani. Congratulations! Read more: www.aventis-foundation.org and bridge.aventis-foundation.org
September 30, 2025 at 8:15 AM
Feeling deeply honored to receive this year's Aventis Life Science Bridge Award. Grateful to the Aventis Foundation for their support, and to my colleagues, mentors, collaborators, and my amazing research team who make this work possible. Excited to keep pushing our HIV research forward together.
Reposted by Konstantin Sparrer
🔬✨ Introducing: Expert Insights – the new seminar series by the Young Society for Virology!
We’ve combined the strengths of our previous “How to” seminar series and the GfV ROUND lunch discussions into one powerful format – Expert Insights.
1/n
We’ve combined the strengths of our previous “How to” seminar series and the GfV ROUND lunch discussions into one powerful format – Expert Insights.
1/n
August 25, 2025 at 1:54 PM
🔬✨ Introducing: Expert Insights – the new seminar series by the Young Society for Virology!
We’ve combined the strengths of our previous “How to” seminar series and the GfV ROUND lunch discussions into one powerful format – Expert Insights.
1/n
We’ve combined the strengths of our previous “How to” seminar series and the GfV ROUND lunch discussions into one powerful format – Expert Insights.
1/n
Reposted by Konstantin Sparrer
Structural basis for OAS2 regulation and its antiviral function
Structural basis for OAS2 regulation and its antiviral function
Merold and Bekere et al. reveal that OAS2 exists as a zinc-mediated dimer in an autoinhibited state, preventing autoreactivity to short RNAs. Dimer-to-monomer transition, dsRNA binding to a non-canonical interface, and targeting to the Golgi by myristoylation are necessary for OAS2 activation and restriction of viruses that form double membrane vesicles.
dlvr.it
June 6, 2025 at 11:33 AM
Structural basis for OAS2 regulation and its antiviral function
Reposted by Konstantin Sparrer
Proud to present a cover inspired by the structural and functional analysis of OAS2 by @oliveiramann.bsky.social, @indrabekere.bsky.social, and Veronika Merold, live at @cp-molcell.bsky.social. Big news on RNA sensing and antiviral defenses!
#sciart ⌬ #research ⌬ #chemistry ⌬ #immunology
#sciart ⌬ #research ⌬ #chemistry ⌬ #immunology
June 13, 2025 at 10:04 AM
Proud to present a cover inspired by the structural and functional analysis of OAS2 by @oliveiramann.bsky.social, @indrabekere.bsky.social, and Veronika Merold, live at @cp-molcell.bsky.social. Big news on RNA sensing and antiviral defenses!
#sciart ⌬ #research ⌬ #chemistry ⌬ #immunology
#sciart ⌬ #research ⌬ #chemistry ⌬ #immunology
Reposted by Konstantin Sparrer
Mit fünf weiteren Fachgesellschaften macht sich die GfV stark dafür, die Wissenschaftsfreiheit zu verteidigen und zu festigen. Leider geschieht dies nicht im luftleeren Raum, sondern in Zeiten, in denen diese essentielle Freiheit zusehends auch bei uns unter Druck gerät.
g-f-v.org/gemeinsame-s...
g-f-v.org/gemeinsame-s...
June 6, 2025 at 3:09 PM
Mit fünf weiteren Fachgesellschaften macht sich die GfV stark dafür, die Wissenschaftsfreiheit zu verteidigen und zu festigen. Leider geschieht dies nicht im luftleeren Raum, sondern in Zeiten, in denen diese essentielle Freiheit zusehends auch bei uns unter Druck gerät.
g-f-v.org/gemeinsame-s...
g-f-v.org/gemeinsame-s...
Reposted by Konstantin Sparrer
How can swarm intelligence improve stroke treatment? A research project links central registry data with local brain imaging – powered by artificial intelligence. Funded by @www.helmholtz.de and under paricipation of @cispa.de.
👉 www.dzne.de/en/news/pres...
👉 www.dzne.de/en/news/pres...
Using Swarm Intelligence to Improve Treatment of Acute Stroke
Research project is combining central registry with local brain imaging data by means of artificial intelligence.
www.dzne.de
June 5, 2025 at 10:52 AM
How can swarm intelligence improve stroke treatment? A research project links central registry data with local brain imaging – powered by artificial intelligence. Funded by @www.helmholtz.de and under paricipation of @cispa.de.
👉 www.dzne.de/en/news/pres...
👉 www.dzne.de/en/news/pres...
Reposted by Konstantin Sparrer
Thrilled to share our latest @cp-cell.bsky.social.
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification
and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune
surveillance mechanism in the nu...
www.cell.com
June 2, 2025 at 3:14 PM
Thrilled to share our latest @cp-cell.bsky.social.
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
Reposted by Konstantin Sparrer
Online Now: Structural basis for OAS2 regulation and its antiviral function Online now:
Structural basis for OAS2 regulation and its antiviral function
Merold and Bekere et al. reveal that OAS2 exists as a zinc-mediated dimer in an autoinhibited state, preventing autoreactivity to short RNAs. Dimer-to-monomer transition, dsRNA binding to a non-canonical interface, and targeting to the Golgi by myristoylation are necessary for OAS2 activation and restriction of viruses that form double membrane vesicles.
dlvr.it
May 23, 2025 at 3:20 PM
Online Now: Structural basis for OAS2 regulation and its antiviral function Online now:
Reposted by Konstantin Sparrer
Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!
Online Now: Structural basis for OAS2 regulation and its antiviral function Online now:
Structural basis for OAS2 regulation and its antiviral function
Merold and Bekere et al. reveal that OAS2 exists as a zinc-mediated dimer in an autoinhibited state, preventing autoreactivity to short RNAs. Dimer-to-monomer transition, dsRNA binding to a non-canonical interface, and targeting to the Golgi by myristoylation are necessary for OAS2 activation and restriction of viruses that form double membrane vesicles.
dlvr.it
May 23, 2025 at 4:31 PM
Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!
Reposted by Konstantin Sparrer
Here is one big reason to choose Europe to advance with your research career:
We 💙 science.
We 💙 science.
May 23, 2025 at 3:03 PM
Here is one big reason to choose Europe to advance with your research career:
We 💙 science.
We 💙 science.