Congratulations 🎊 👏 💐 🥳

👉 @same18-bcn.bsky.social @ramalok.bsky.social
@microbiomacsic.bsky.social @ice-csic.bsky.social @soniagr.bsky.social @itq-upvcsic.bsky.social @sribo.bsky.social @sebbm.bsky.social y @esanchezsanchez.bsky.social
👋👋 ¡Gracias por seguirnos! 👋👋
#cienciaparalaagricultura

🎤 Excited to learn how RNA splicing is linked to Alzheimer’s? @soniagr.bsky.social (UK Dementia Research Institute) will unveil insights from single-nucleus RNA-seq at the Cambridge RNA Club!
Join us for cutting-edge science & stay for networking 🍕on 20th Feb at 17h in @cambiochem.bsky.social

Wow, I love it!

6) This has been an extensive collaborative team effort! Thanks to @jwbrenton.bsky.social MelissaGrant-Peters ZhongboChen EmilKGustavson ReginaHReynolds @lcolladotor.bsky.social
AineFairbrother-Browne and many more from our lab (RytenLab rytenlab.xn--com)-876aaa40307gka16qcac854l97a7k

5) Overall, this in-depth characterisation of splicing accuracy can expand our understanding of the role of inaccuracies in ageing and neurodegenerative disorders.

4/ Key findings 🔑 3) We observe a genome-wide increase in splicing inaccuracies in samples affected with Alzheimer’s disease compared to neurologically normal individuals. 🧠

3) Key findings 🔑 2) We find that age is positively correlated with a global decline in splicing fidelity, mostly affecting genes implicated in neurodegenerative diseases. 💆‍♂️ #ageing #splicingnoise #splicingaccuracy #neurodegeneration

2) Key findings 🔑1) We show that splicing inaccuracies occur at different rates across introns and tissues and are affected by the abundance of core components of the spliceosome assembly and its regulators. #RNAbindingProteins #NMDpathway

1) Methods📝 We investigate splicing accuracy using short-read RNA-sequencing data from >14k control samples and 40 human body sites, focusing on split reads that partially map to known transcripts in the reference annotation.