smishra677.bsky.social
@smishra677.bsky.social
Reposted
New preprint led by grad student, Yu Mo! We introduce new software to calculate evolutionary rates of quantitative characters in the presence of discordance

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www.biorxiv.org/content/10.1...
Estimating the rate of quantitative trait evolution in the presence of gene tree discordance by calculating likelihoods across trees
Quantitative traits provide insights into how phenotypes evolve across species. However, standard comparative methods often assume a single species tree and overlook the discordant gene tree histories...
www.biorxiv.org
October 7, 2025 at 3:10 PM
Reposted
Happy that our new paper is out, led by super-postbacc Daniel Rickert (now a PhD student at UNC). Also kind of excited to have my first TPB paper...

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"Inconsistency of parsimony under the multispecies coalescent"
www.sciencedirect.com/science/arti...
Inconsistency of parsimony under the multispecies coalescent
While it is known that parsimony can be statistically inconsistent under certain models of evolution due to high levels of homoplasy, the consistency …
www.sciencedirect.com
September 30, 2025 at 2:06 PM
Reposted
New paper led by @yadirapga.bsky.social!

Opossums have babies at 6-months of age, but are still highly male-biased in their mutations

academic.oup.com/genetics/adv...
Low mutation rate but high male-bias in the germline of a short-lived opossum
Abstract. Age and sex have been found to be important determinants of the mutation rate per generation in mammals, but the mechanisms underlying these fact
academic.oup.com
September 1, 2025 at 7:09 PM
Reposted
In #GENETICS, @3rdreviewer.bsky.social‬ and @smishra677.bsky.social‬ show it is possible to estimate recombination solely using the allele frequency spectrum and provide a genealogical interpretation of the results, showing how #MachineLearning can provide insights into biology.

buff.ly/emixz9W
July 16, 2025 at 10:04 PM
Reposted
Our paper (w/ @smishra677.bsky.social) is now out in Genetics!

academic.oup.com/genetics/adv...
June 6, 2025 at 6:33 PM
Reposted
New paper with Sarthak Mishra! Maybe it will bring you some joy given all this (waves arms around).

"Estimating recombination using only the allele frequency spectrum"

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www.biorxiv.org/content/10.1...
Estimating recombination using only the allele frequency spectrum
Standard methods for estimating the population recombination parameter, rho, are dependent on sampling individual genotypes and calculating various types of disequilibria. However, recent machine lear...
www.biorxiv.org
February 6, 2025 at 4:29 PM