Solveigh Koeberle
@skoeberle.bsky.social
Ferroptosis-modulating Redox Therapeutics ▪ Electrophilic Natural Products ▪ Redox Signaling ▪ Inflammation ▪ Cancer ▪ Degenerative Diseases
Reposted by Solveigh Koeberle
a must read
Great to see our Nature Chemistry paper out in its final published and printed form.
If you want to check it out, you can find it here: www.nature.com/articles/s41...
#ChemSky #ChemBio #ChemicalProteomics #Chemoproteomics #ProteoProbes #ChemPro
If you want to check it out, you can find it here: www.nature.com/articles/s41...
#ChemSky #ChemBio #ChemicalProteomics #Chemoproteomics #ProteoProbes #ChemPro
November 21, 2025 at 8:31 PM
a must read
Reposted by Solveigh Koeberle
Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉
aprecruit.berkeley.edu/JPF05098
aprecruit.berkeley.edu/JPF05098
August 21, 2025 at 4:00 AM
Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉
aprecruit.berkeley.edu/JPF05098
aprecruit.berkeley.edu/JPF05098
Reposted by Solveigh Koeberle
Excited to share our latest publication in which we uncover a link between ether phospholipid degradation and lipid mediator biosynthesis! This collaboration with the Katrin Watschinger lab provides new insights on sex-dependent lipid metabolism and signaling.
rdcu.be/epE1w
rdcu.be/epE1w
June 7, 2025 at 11:43 AM
Excited to share our latest publication in which we uncover a link between ether phospholipid degradation and lipid mediator biosynthesis! This collaboration with the Katrin Watschinger lab provides new insights on sex-dependent lipid metabolism and signaling.
rdcu.be/epE1w
rdcu.be/epE1w
Reposted by Solveigh Koeberle
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9
Brief Skytorial!
1/9
Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS
FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced
forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...
www.pnas.org
May 29, 2025 at 6:02 PM
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9
Brief Skytorial!
1/9
Reposted by Solveigh Koeberle
"Science is an investment.
We will put forward a new 500 million package for 2025-2027 to support the best and the brightest researchers and scientists from Europe and around the world."
— President @vonderleyen.ec.europa.eu at the ‘Choose Europe for Science' event at La Sorbonne 🇫🇷
We will put forward a new 500 million package for 2025-2027 to support the best and the brightest researchers and scientists from Europe and around the world."
— President @vonderleyen.ec.europa.eu at the ‘Choose Europe for Science' event at La Sorbonne 🇫🇷
May 5, 2025 at 10:16 AM
"Science is an investment.
We will put forward a new 500 million package for 2025-2027 to support the best and the brightest researchers and scientists from Europe and around the world."
— President @vonderleyen.ec.europa.eu at the ‘Choose Europe for Science' event at La Sorbonne 🇫🇷
We will put forward a new 500 million package for 2025-2027 to support the best and the brightest researchers and scientists from Europe and around the world."
— President @vonderleyen.ec.europa.eu at the ‘Choose Europe for Science' event at La Sorbonne 🇫🇷
Reposted by Solveigh Koeberle
Registration is open for our summer FASEB #Ferroptosis Conference July 27 - 31, 2025. We have a terrific line up of speakers and it's going to be amazzzing! Come join us for this historic first meeting! Please help us to spread the word. 🤩
shorturl.at/QA6T1
shorturl.at/QA6T1
February 13, 2025 at 6:27 AM
Registration is open for our summer FASEB #Ferroptosis Conference July 27 - 31, 2025. We have a terrific line up of speakers and it's going to be amazzzing! Come join us for this historic first meeting! Please help us to spread the word. 🤩
shorturl.at/QA6T1
shorturl.at/QA6T1
Reposted by Solveigh Koeberle
Another layer of mitochondrial regulation of ferroptosis. Very interesting!
Cytosolic cytochrome c represses ferroptosis: Cell Metabolism www.cell.com/cell-metabol...
Cytosolic cytochrome c represses ferroptosis
Song et al. demonstrated that the cytosolic CYCS-INPP4A complex inhibits ferroptosis
by promoting phosphatidylinositol-3-phosphate synthesis and preventing phospholipid
peroxidation. The small molecul...
www.cell.com
April 18, 2025 at 2:04 PM
Another layer of mitochondrial regulation of ferroptosis. Very interesting!
Reposted by Solveigh Koeberle
The GDCh has signed ALLEA's statement against recent US restrictions on science and research. Together, we appeal to remain vigilant and stand up for academic freedom and the autonomy of scientific institutions.
allea.org/portfolio-it...
allea.org/portfolio-it...
ALLEA Statement on Threats to Academic Freedom and International Research Collaboration in the United States
allea.org
March 24, 2025 at 1:58 PM
The GDCh has signed ALLEA's statement against recent US restrictions on science and research. Together, we appeal to remain vigilant and stand up for academic freedom and the autonomy of scientific institutions.
allea.org/portfolio-it...
allea.org/portfolio-it...
Reposted by Solveigh Koeberle
🧫 Ein internationales Forschungsteam rund um Andreas Koeberle hat einen Mechanismus entdeckt, der neue Behandlungsstrategien für Tumore eröffnet, bei denen konventionelle Chemotherapeutika an ihre Grenzen stoßen:
🔗 www.uni-graz.at/de/neuigkeit...
#weworkfortomorrow
🔗 www.uni-graz.at/de/neuigkeit...
#weworkfortomorrow
February 25, 2025 at 11:40 AM
🧫 Ein internationales Forschungsteam rund um Andreas Koeberle hat einen Mechanismus entdeckt, der neue Behandlungsstrategien für Tumore eröffnet, bei denen konventionelle Chemotherapeutika an ihre Grenzen stoßen:
🔗 www.uni-graz.at/de/neuigkeit...
#weworkfortomorrow
🔗 www.uni-graz.at/de/neuigkeit...
#weworkfortomorrow
Reposted by Solveigh Koeberle
💊 Dem Leberfett zu Leibe gerückt: Die Uni-Graz-Pharmakognostin Solveigh Koeberle forscht an neuen Medikamenten für degenerative Erkrankungen. www.uni-graz.at/de/neuigkeit...
February 28, 2025 at 9:07 AM
💊 Dem Leberfett zu Leibe gerückt: Die Uni-Graz-Pharmakognostin Solveigh Koeberle forscht an neuen Medikamenten für degenerative Erkrankungen. www.uni-graz.at/de/neuigkeit...
Reposted by Solveigh Koeberle
Curious about the interplay between #apoptosis and #ferroptosis and their role in cytotoxic stress, whether induced by drugs or serum depletion? Check out our latest paper in #NatureCommunications.
rdcu.be/ebbYX
@unigraz #CellDeath #LipidMetabolism
rdcu.be/ebbYX
@unigraz #CellDeath #LipidMetabolism
February 25, 2025 at 11:40 AM
Curious about the interplay between #apoptosis and #ferroptosis and their role in cytotoxic stress, whether induced by drugs or serum depletion? Check out our latest paper in #NatureCommunications.
rdcu.be/ebbYX
@unigraz #CellDeath #LipidMetabolism
rdcu.be/ebbYX
@unigraz #CellDeath #LipidMetabolism