Simon Bayly
@simonbayly.bsky.social
Reformed chemist 👨🔬 IP licensing and spinouts at the Francis Crick Institute. Also post about cycling 🚲 Opinion my own etc.
Pinned
Simon Bayly
@simonbayly.bsky.social
· Oct 17
Welcome new Bluesky users! If you are into biotech, please use the feed I created: bsky.app/profile/did:...
Found an interesting post on LinkedIn* on publishing vs patenting in the age of AI
*the second time in a week, what's happening?
www.linkedin.com/posts/simon-...
*the second time in a week, what's happening?
www.linkedin.com/posts/simon-...
How AI is disrupting biopharma innovation with CoM patents | Simon Goldman posted on the topic | LinkedIn
AI’s ability to rapidly bust ‘gold-standard’ composition-of-matter (CoM) #IP will have a major impact on universities’ centuries-old ‘patent + dissemination’-based #biopharma #innovation process.
A ...
www.linkedin.com
November 10, 2025 at 12:36 PM
Found an interesting post on LinkedIn* on publishing vs patenting in the age of AI
*the second time in a week, what's happening?
www.linkedin.com/posts/simon-...
*the second time in a week, what's happening?
www.linkedin.com/posts/simon-...
Reposted by Simon Bayly
This image shows a mass of human stem cells, collectively known as an ‘organoid’.
We stained the neural crest cells of this organoid to better understand diseases related to defects in their development, such as Hirschsprung's disease and Neuroblastoma.
Image credit: @carmenmorenogon.bsky.social
We stained the neural crest cells of this organoid to better understand diseases related to defects in their development, such as Hirschsprung's disease and Neuroblastoma.
Image credit: @carmenmorenogon.bsky.social
November 10, 2025 at 9:27 AM
This image shows a mass of human stem cells, collectively known as an ‘organoid’.
We stained the neural crest cells of this organoid to better understand diseases related to defects in their development, such as Hirschsprung's disease and Neuroblastoma.
Image credit: @carmenmorenogon.bsky.social
We stained the neural crest cells of this organoid to better understand diseases related to defects in their development, such as Hirschsprung's disease and Neuroblastoma.
Image credit: @carmenmorenogon.bsky.social
Do you think this deal will work out for Pfizer?
My feeling is that the earning lifetime of Metsera’s lead products will be short as better (e.g. oral, muscle preserving) anti obesity drugs are just around the corner
www.ft.com/content/d9f5...
My feeling is that the earning lifetime of Metsera’s lead products will be short as better (e.g. oral, muscle preserving) anti obesity drugs are just around the corner
www.ft.com/content/d9f5...
Pfizer wins $10bn bidding war for weight-loss start-up Metsera
Biotech says it opted for revised offer from US pharma company after rival Novo bid raised antitrust concerns
www.ft.com
November 8, 2025 at 10:22 AM
Do you think this deal will work out for Pfizer?
My feeling is that the earning lifetime of Metsera’s lead products will be short as better (e.g. oral, muscle preserving) anti obesity drugs are just around the corner
www.ft.com/content/d9f5...
My feeling is that the earning lifetime of Metsera’s lead products will be short as better (e.g. oral, muscle preserving) anti obesity drugs are just around the corner
www.ft.com/content/d9f5...
Reposted by Simon Bayly
Scientific breakthroughs are rarely unique; someone else would’ve made them soon enough. But when prominent scientists cause harm, that harm isn’t inevitable; the world might simply have been better had the harm not been inflicted.
liorpachter.wordpress.com/2018/05/18/j...
liorpachter.wordpress.com/2018/05/18/j...
James Watson in his own words
“Some anti-Semitism is justified” “Whenever you interview fat people, you feel bad, because you know you’re not going to hire them” “Japan should be bombed for d…
liorpachter.wordpress.com
November 8, 2025 at 4:29 AM
Scientific breakthroughs are rarely unique; someone else would’ve made them soon enough. But when prominent scientists cause harm, that harm isn’t inevitable; the world might simply have been better had the harm not been inflicted.
liorpachter.wordpress.com/2018/05/18/j...
liorpachter.wordpress.com/2018/05/18/j...
Reposted by Simon Bayly
Happy 158th Birthday, Marie Skłodowska Curie! She was the first woman to receive a Nobel Prize and the first person to receive the honor twice.
In 2017, #ScienceBooks toured the dynamics that established her as "the most iconic of all female scientists." https://scim.ag/47tkKYA
In 2017, #ScienceBooks toured the dynamics that established her as "the most iconic of all female scientists." https://scim.ag/47tkKYA
The making and remaking of Marie Curie
The famous physicist's legacy looms large 150 years after her birth
www.science.org
November 7, 2025 at 2:47 PM
Happy 158th Birthday, Marie Skłodowska Curie! She was the first woman to receive a Nobel Prize and the first person to receive the honor twice.
In 2017, #ScienceBooks toured the dynamics that established her as "the most iconic of all female scientists." https://scim.ag/47tkKYA
In 2017, #ScienceBooks toured the dynamics that established her as "the most iconic of all female scientists." https://scim.ag/47tkKYA
Reposted by Simon Bayly
In today's episode of Biomolecules Doing Unexpected Things - Telomerase Reverse Transcriptase messes about in mitochondria
'Because of its main activity on telomeric DNA, TERT is expected to localize in the nucleus, but its sequence is characterized by a nuclear exporting signal and a mitochondrial translocation signal, which together confer the ability to migrate in the cytoplasm and subsequently into mitochondria'
journals.plos.org
November 7, 2025 at 5:10 PM
In today's episode of Biomolecules Doing Unexpected Things - Telomerase Reverse Transcriptase messes about in mitochondria
Reposted by Simon Bayly
More strange shenanigans in #biotech "Biohub spokesperson said it was acquiring EvolutionaryScale’s team of about 50 people, but not buying the company itself. It’s unclear what will happen to any of its assets."
endpoints.news/zuckerberg-b...
endpoints.news/zuckerberg-b...
Zuckerberg-backed Biohub hires EvolutionaryScale team in apparent end of AI startup
EvolutionaryScale's top team of founders has been hired by a new nonprofit called Biohub backed by Mark Zuckerberg and his wife Priscilla Chan.
endpoints.news
November 7, 2025 at 4:56 PM
More strange shenanigans in #biotech "Biohub spokesperson said it was acquiring EvolutionaryScale’s team of about 50 people, but not buying the company itself. It’s unclear what will happen to any of its assets."
endpoints.news/zuckerberg-b...
endpoints.news/zuckerberg-b...
In today's episode of Biomolecules Doing Unexpected Things - Telomerase Reverse Transcriptase messes about in mitochondria
'Because of its main activity on telomeric DNA, TERT is expected to localize in the nucleus, but its sequence is characterized by a nuclear exporting signal and a mitochondrial translocation signal, which together confer the ability to migrate in the cytoplasm and subsequently into mitochondria'
journals.plos.org
November 7, 2025 at 5:10 PM
In today's episode of Biomolecules Doing Unexpected Things - Telomerase Reverse Transcriptase messes about in mitochondria
More strange shenanigans in #biotech "Biohub spokesperson said it was acquiring EvolutionaryScale’s team of about 50 people, but not buying the company itself. It’s unclear what will happen to any of its assets."
endpoints.news/zuckerberg-b...
endpoints.news/zuckerberg-b...
Zuckerberg-backed Biohub hires EvolutionaryScale team in apparent end of AI startup
EvolutionaryScale's top team of founders has been hired by a new nonprofit called Biohub backed by Mark Zuckerberg and his wife Priscilla Chan.
endpoints.news
November 7, 2025 at 4:56 PM
More strange shenanigans in #biotech "Biohub spokesperson said it was acquiring EvolutionaryScale’s team of about 50 people, but not buying the company itself. It’s unclear what will happen to any of its assets."
endpoints.news/zuckerberg-b...
endpoints.news/zuckerberg-b...
Reposted by Simon Bayly
My favorite comment on the FT story
November 6, 2025 at 7:49 PM
My favorite comment on the FT story
Reposted by Simon Bayly
Beautiful discovery by the Huber and Kubicek labs and a wonderful example of using targeted protein degradation to probe novel non-catalytic functions.
New in @science.org 🧬
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis
Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...
www.science.org
November 6, 2025 at 8:12 PM
Beautiful discovery by the Huber and Kubicek labs and a wonderful example of using targeted protein degradation to probe novel non-catalytic functions.
Today I learned that Fokker-Planck is an important equation and not just what science students say when they learn who is responsible for the birth of quantum physics
(1/n) Can diffusion models simulate molecular dynamics instead of just generating independent samples?
In our NeurIPS 2025 paper, we train energy-based diffusion models that can do both:
- Generate independent samples
- Learn the underlying potential 𝑼
🧵👇
Paper: arxiv.org/abs/2506.17139
In our NeurIPS 2025 paper, we train energy-based diffusion models that can do both:
- Generate independent samples
- Learn the underlying potential 𝑼
🧵👇
Paper: arxiv.org/abs/2506.17139
November 6, 2025 at 8:42 PM
Today I learned that Fokker-Planck is an important equation and not just what science students say when they learn who is responsible for the birth of quantum physics
Saturation genome editing and why it's important
We each carry around six million variations in our DNA.
Henry Scowcroft explores how scientists like @gregfindlay.bsky.social and @carovinuesa.bsky.social are helping unravel the effects of these variants, where even a small change can have a big impact on our lives.
www.crick.ac.uk/news/2025-10...
Henry Scowcroft explores how scientists like @gregfindlay.bsky.social and @carovinuesa.bsky.social are helping unravel the effects of these variants, where even a small change can have a big impact on our lives.
www.crick.ac.uk/news/2025-10...
Variants: the typos turning loss into hope
Across the 3 billion ‘letters’ of our DNA, we each carry around 6 million variations. Researchers are unravelling their effects on our lives.
www.crick.ac.uk
November 6, 2025 at 4:02 PM
Saturation genome editing and why it's important
Reposted by Simon Bayly
How does immunotherapy work, and why do some patients respond while others don’t?
Book our free talk by Samra Turajlic, head of the Cancer Dynamics Lab here at the Crick, Director of @cruk-mi.bsky.social and head of the UK-wide MANIFEST programme.
www.eventbrite.co.uk/e/crick-cras...
Book our free talk by Samra Turajlic, head of the Cancer Dynamics Lab here at the Crick, Director of @cruk-mi.bsky.social and head of the UK-wide MANIFEST programme.
www.eventbrite.co.uk/e/crick-cras...
Crick Crash Course: Immunotherapy
Our series of morning lectures sharing science from across the Crick in a simple and accessible way continues.
www.eventbrite.co.uk
November 6, 2025 at 9:15 AM
How does immunotherapy work, and why do some patients respond while others don’t?
Book our free talk by Samra Turajlic, head of the Cancer Dynamics Lab here at the Crick, Director of @cruk-mi.bsky.social and head of the UK-wide MANIFEST programme.
www.eventbrite.co.uk/e/crick-cras...
Book our free talk by Samra Turajlic, head of the Cancer Dynamics Lab here at the Crick, Director of @cruk-mi.bsky.social and head of the UK-wide MANIFEST programme.
www.eventbrite.co.uk/e/crick-cras...
"How to spin research into profits" #spinout moneyweek.com/investments/...
Investing in UK universities: how to spin research into profits
UK universities are a vital economic asset, but they are also Britain's 'equivalent of Gulf oil.' There are opportunities here for investors, says Matthew Partridge
moneyweek.com
November 6, 2025 at 8:28 AM
"How to spin research into profits" #spinout moneyweek.com/investments/...
For a very long time the USA has been the obvious first choice of where to seek approval for new drugs. People are starting to question that.
Experts worry FDA’s credibility is being shredded by scandal and 'embarassing' ‘soap opera’ 'clown show' www.statnews.com/2025/11/04/f...
Experts worry FDA’s credibility is being shredded by scandal and 'soap opera'
Experts worry that the FDA’s credibility is being shredded by scandal and "soap opera."
www.statnews.com
November 5, 2025 at 2:09 PM
For a very long time the USA has been the obvious first choice of where to seek approval for new drugs. People are starting to question that.
Reposted by Simon Bayly
Burry’s Palantir trade is roughly an order of magnitude bigger—and more interesting imo—than the Nvidia puts.
The guy who got famous betting against the housing market in 2007 just before that bubble burst - played by Christian Bale jn “The Big Short” - just wagered $1 billion on the collapse of the AI boom.
www.wsj.com/livecoverage...
www.wsj.com/livecoverage...
Michael Burry Returns With Two Big Shorts: Palantir and Nvidia
Signs of an AI bubble abound: Stock valuations have become uncomfortably rich, AI-related debt is ballooning, and a sustainable financial model for the technology has largely yet to emerge. Now Michae...
www.wsj.com
November 4, 2025 at 9:55 PM
Burry’s Palantir trade is roughly an order of magnitude bigger—and more interesting imo—than the Nvidia puts.
This is a bit weird. Did the backers have unrealistic expectations?https://www.statnews.com/2025/11/04/arena-bioworks-research-institute-shuts-down/
Arena BioWorks, an ambitious biomedical institute backed by billionaires, abruptly shuts down
Exclusive: Arena Bioworks, the buzzy research institute that launched with $500 million to support a decade of scientific R&D, is abruptly shutting down, STAT has learned.
www.statnews.com
November 4, 2025 at 9:58 PM
This is a bit weird. Did the backers have unrealistic expectations?https://www.statnews.com/2025/11/04/arena-bioworks-research-institute-shuts-down/
Reposted by Simon Bayly
Da da da dum dee dum dee dum
November 3, 2025 at 1:28 PM
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Da da da dum dee dum dee dum
November 3, 2025 at 1:28 PM
Da da da dum dee dum dee dum
Reposted by Simon Bayly
This was written in 2017. The current political moment was completely avoidable. ”the pain of looking back and seeing that there was a small window in which it was possible to act, and then discovering how suddenly and irrevocably that window can be slammed shut.”
www.newyorker.com/books/page-t...
www.newyorker.com/books/page-t...
When It’s Too Late to Stop Fascism, According to Stefan Zweig
I wonder how far along the scale of moral degeneration Zweig would judge America to be in its current state.
www.newyorker.com
November 1, 2025 at 6:52 AM
This was written in 2017. The current political moment was completely avoidable. ”the pain of looking back and seeing that there was a small window in which it was possible to act, and then discovering how suddenly and irrevocably that window can be slammed shut.”
www.newyorker.com/books/page-t...
www.newyorker.com/books/page-t...
Terrifying!
When all your PCRs fail, except for the negative control 😱
October 31, 2025 at 8:31 AM
Terrifying!
Two really interesting LinkedIn posts (IKR!) on modelling biological systems. Read the quoted one first. www.linkedin.com/pulse/right-...
October 30, 2025 at 2:55 PM
Two really interesting LinkedIn posts (IKR!) on modelling biological systems. Read the quoted one first. www.linkedin.com/pulse/right-...
Reposted by Simon Bayly
Opportunity for lab-based medicinal chemist/chemical biologist at The Francis Crick Institute (London UK) ref: R2461 | closing: 11-Nov-2025 #MedChem #ChemBiol #SynChem #ChemJobs #UKChemJobs #chemsky 🧪
crick.wd3.myworkdayjobs.com/External/job...
crick.wd3.myworkdayjobs.com/External/job...
Senior Laboratory Research Scientist - Medicinal Chemist/Chemical Biologist
Salary for this Role: From £45,700 with benefits, subject to skills & experience Job Title: Senior Laboratory Research Scientist - Medicinal Chemist/Chemical Biologist Reports to: Christelle Soudy...
crick.wd3.myworkdayjobs.com
October 29, 2025 at 7:22 AM
Opportunity for lab-based medicinal chemist/chemical biologist at The Francis Crick Institute (London UK) ref: R2461 | closing: 11-Nov-2025 #MedChem #ChemBiol #SynChem #ChemJobs #UKChemJobs #chemsky 🧪
crick.wd3.myworkdayjobs.com/External/job...
crick.wd3.myworkdayjobs.com/External/job...