Simak
@simak.bsky.social
Researching breast & prostate cancer.
Molecular biology, genetics, biochemistry. Cancer genes of special focus: estrogen & androgen receptors, cyclin-dependent kinases.
http://imperial.ac.uk/people/simak.ali
Molecular biology, genetics, biochemistry. Cancer genes of special focus: estrogen & androgen receptors, cyclin-dependent kinases.
http://imperial.ac.uk/people/simak.ali
Super insight into regulation of CDK activities @vcushing.bsky.social, @bjgreber.bsky.social
October 17, 2025 at 8:38 PM
Super insight into regulation of CDK activities @vcushing.bsky.social, @bjgreber.bsky.social
Our work flags new therapeutic opportunities for patients who progress on/after hormone therapies, including VGLL1/TEAD inhibitors & drugs targeting EGFR
Thanks to a super collaboration with @magnanilab.bsky.social, funding from @cancerresearchuk.org and support from @imperialsandc.bsky.social
Thanks to a super collaboration with @magnanilab.bsky.social, funding from @cancerresearchuk.org and support from @imperialsandc.bsky.social
January 4, 2025 at 1:14 PM
Our work flags new therapeutic opportunities for patients who progress on/after hormone therapies, including VGLL1/TEAD inhibitors & drugs targeting EGFR
Thanks to a super collaboration with @magnanilab.bsky.social, funding from @cancerresearchuk.org and support from @imperialsandc.bsky.social
Thanks to a super collaboration with @magnanilab.bsky.social, funding from @cancerresearchuk.org and support from @imperialsandc.bsky.social
Reposted by Simak
From these data, we derived the mechanism of CDK7-selectivity of the clinical compound and formulated a hypothesis for a secondary mechanism of selectivity in this compound class. We tested this hypothesis successfully by analysis of the compound CT7030.
March 14, 2024 at 10:03 AM
From these data, we derived the mechanism of CDK7-selectivity of the clinical compound and formulated a hypothesis for a secondary mechanism of selectivity in this compound class. We tested this hypothesis successfully by analysis of the compound CT7030.
Reposted by Simak
A number of artists and creators have made their home on Bluesky, and we hear their concerns with other platforms training on their data. We do not use any of your content to train generative AI, and have no intention of doing so.
November 15, 2024 at 5:22 PM
A number of artists and creators have made their home on Bluesky, and we hear their concerns with other platforms training on their data. We do not use any of your content to train generative AI, and have no intention of doing so.