Simak
@simak.bsky.social
Researching breast & prostate cancer.
Molecular biology, genetics, biochemistry. Cancer genes of special focus: estrogen & androgen receptors, cyclin-dependent kinases.
http://imperial.ac.uk/people/simak.ali
Molecular biology, genetics, biochemistry. Cancer genes of special focus: estrogen & androgen receptors, cyclin-dependent kinases.
http://imperial.ac.uk/people/simak.ali
We show a single amino acid change in CDK7 causes acquired resistance to CDK7i in cancer cells. There are implications for patient selection,resistance monitoring and switching treatments. thanks to @vcushing.bsky.social @bjgreber.bsky.social @prostatecanceruk.bsky.social
doi.org/10.1038/s443...
doi.org/10.1038/s443...
September 8, 2025 at 7:18 PM
We show a single amino acid change in CDK7 causes acquired resistance to CDK7i in cancer cells. There are implications for patient selection,resistance monitoring and switching treatments. thanks to @vcushing.bsky.social @bjgreber.bsky.social @prostatecanceruk.bsky.social
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Our publication in Cancer Research (DOI: 10.1158/0008-5472.CAN-24-0013) reveals a route to hormone therapy resistance in #ER-positive breast cancer patients. We show that induction of #VGLL1 drives gene expression programmes that confer resistance to ER degraders.
January 4, 2025 at 1:14 PM
Our publication in Cancer Research (DOI: 10.1158/0008-5472.CAN-24-0013) reveals a route to hormone therapy resistance in #ER-positive breast cancer patients. We show that induction of #VGLL1 drives gene expression programmes that confer resistance to ER degraders.