Silvia Cappello
@silvianeuro.bsky.social
Developmental Neurobiologist, Mountain Lover.
Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids | EMBO reports www.embopress.org/doi/full/10....
Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids | EMBO reports
imageimageHuman progenitors are programmed into ependymal cells in brain organoids via GEMC1
and MCIDAS expression. This strategy recapitulates hallmarks of the adult human V-SVZ
niche, providing a pl...
www.embopress.org
November 10, 2025 at 12:22 PM
Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids | EMBO reports www.embopress.org/doi/full/10....
Reposted by Silvia Cappello
Application to present at the Second Italian Glia Network Symposium is closing next week. Apply your abstract by Oct 10!!! Do not miss the opportunity to discuss your research in a young and informal community !!! #Glia
October 5, 2025 at 5:59 PM
Application to present at the Second Italian Glia Network Symposium is closing next week. Apply your abstract by Oct 10!!! Do not miss the opportunity to discuss your research in a young and informal community !!! #Glia
Reposted by Silvia Cappello
New research identifies Galectin-3 as a key regulator of neural development, establishing its contribution to brain growth.
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/46mJrGO
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/46mJrGO
September 5, 2025 at 10:39 PM
New research identifies Galectin-3 as a key regulator of neural development, establishing its contribution to brain growth.
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/46mJrGO
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/46mJrGO
Reposted by Silvia Cappello
Neue Heisenberg-Professur für die FAU: Prof. Dr. Ruth Beckervordersandforth wird von der @dfg.de gefördert 👏
Beckervordersandforth untersucht Astrozyten, die die Funktion von Nervenzellen im Gehirn unterstützen und regulieren.
Mehr über ihre Forschung erfahren: www.fau.de/2025/09/news...
Beckervordersandforth untersucht Astrozyten, die die Funktion von Nervenzellen im Gehirn unterstützen und regulieren.
Mehr über ihre Forschung erfahren: www.fau.de/2025/09/news...
Neue Heisenberg-Professur für die FAU
Großer Erfolg für die FAU: Die Deutsche Forschungsgemeinschaft (DFG) hat Prof. Dr. Ruth Beckervordersandforth, Professur für Molekulare Neuropathologie an der Friedrich-Alexander-Universität Erlangen…
www.fau.de
September 3, 2025 at 7:04 AM
Neue Heisenberg-Professur für die FAU: Prof. Dr. Ruth Beckervordersandforth wird von der @dfg.de gefördert 👏
Beckervordersandforth untersucht Astrozyten, die die Funktion von Nervenzellen im Gehirn unterstützen und regulieren.
Mehr über ihre Forschung erfahren: www.fau.de/2025/09/news...
Beckervordersandforth untersucht Astrozyten, die die Funktion von Nervenzellen im Gehirn unterstützen und regulieren.
Mehr über ihre Forschung erfahren: www.fau.de/2025/09/news...
Reposted by Silvia Cappello
The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3
May 22, 2025 at 6:10 PM
The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3
Reposted by Silvia Cappello
Three amazing days of the #neurogen2025 conference at @humantechnopole.bsky.social in Milan. Many thanks to all the participants, speakers and fellow co-organizers. We heard fantastic talks in #neurodevelopment #brainevolution #cancerneuroscience #neuroimmunology #neurodegeneration #neurodiversity
May 21, 2025 at 6:18 PM
Three amazing days of the #neurogen2025 conference at @humantechnopole.bsky.social in Milan. Many thanks to all the participants, speakers and fellow co-organizers. We heard fantastic talks in #neurodevelopment #brainevolution #cancerneuroscience #neuroimmunology #neurodegeneration #neurodiversity
Reposted by Silvia Cappello
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
www.nature.com
May 14, 2025 at 4:09 PM
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
Reposted by Silvia Cappello
Excellent work from @silvianeuro.bsky.social lab, led by a brilliant young scholar, @mveronicapravata.bsky.social, on
the impact of a mutation in DCHS1 distinguishing sapiens from Neandertals: shifting the ratio between cortical & striatal progenitors
(Nice to see work going beyond the cortex) 🧪🧠🧬🧫
the impact of a mutation in DCHS1 distinguishing sapiens from Neandertals: shifting the ratio between cortical & striatal progenitors
(Nice to see work going beyond the cortex) 🧪🧠🧬🧫
DCHS1 Modulates Forebrain Proportions in Modern Humans via a Glycosylation Change
Comparative anatomical studies of primates and extinct hominins, including Neanderthals, show that the modern human brain is characterised by a disproportionately enlarged neocortex relative to the st...
www.biorxiv.org
May 15, 2025 at 5:59 AM
Excellent work from @silvianeuro.bsky.social lab, led by a brilliant young scholar, @mveronicapravata.bsky.social, on
the impact of a mutation in DCHS1 distinguishing sapiens from Neandertals: shifting the ratio between cortical & striatal progenitors
(Nice to see work going beyond the cortex) 🧪🧠🧬🧫
the impact of a mutation in DCHS1 distinguishing sapiens from Neandertals: shifting the ratio between cortical & striatal progenitors
(Nice to see work going beyond the cortex) 🧪🧠🧬🧫
Reposted by Silvia Cappello
Latest publication from the lab just out in @dev-journal.bsky.social.
Find out what happens to the cerebral cortex when depleted from Cajal-Retzius cells...
doi.org/10.1242/dev....
Congrats to all authors, and special thanks to Vicente Elorriaga, Benoit Bouloudi and Nathalie Spassky
Find out what happens to the cerebral cortex when depleted from Cajal-Retzius cells...
doi.org/10.1242/dev....
Congrats to all authors, and special thanks to Vicente Elorriaga, Benoit Bouloudi and Nathalie Spassky
May 8, 2025 at 3:39 PM
Latest publication from the lab just out in @dev-journal.bsky.social.
Find out what happens to the cerebral cortex when depleted from Cajal-Retzius cells...
doi.org/10.1242/dev....
Congrats to all authors, and special thanks to Vicente Elorriaga, Benoit Bouloudi and Nathalie Spassky
Find out what happens to the cerebral cortex when depleted from Cajal-Retzius cells...
doi.org/10.1242/dev....
Congrats to all authors, and special thanks to Vicente Elorriaga, Benoit Bouloudi and Nathalie Spassky
Regional differences in progenitor metabolism shape brain growth during development: Cell www.cell.com/cell/fulltex...
Regional differences in progenitor metabolism shape brain growth during development
Brain-wide birthdate mapping reveals that while hindbrain neurogenesis is transient,
forebrain neurogenesis is temporally sustained through spatiotemporal regulation of
progenitor mitochondrial functi...
www.cell.com
May 2, 2025 at 11:10 AM
Regional differences in progenitor metabolism shape brain growth during development: Cell www.cell.com/cell/fulltex...
Exploring human brain development and disease using assembloids: Neuron www.cell.com/neuron/fullt...
Exploring human brain development and disease using assembloids
Wu and Nowakowski review the progression of in vitro human brain models, highlighting
the applications of assembloids in studying development and disease. They further
discuss the current challenges a...
www.cell.com
May 1, 2025 at 2:37 PM
Exploring human brain development and disease using assembloids: Neuron www.cell.com/neuron/fullt...
Reposted by Silvia Cappello
🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex?
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...
3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development
The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...
www.biorxiv.org
March 13, 2025 at 9:59 AM
🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex?
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...
Reposted by Silvia Cappello
💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 13, 2025 at 10:11 AM
💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Silvia Cappello
In this week’s @nature.com, we publish a group effort to outline a framework for studies with neural #organoids, #assembloids and transplantation. More details below 1/n
March 14, 2025 at 8:20 PM
In this week’s @nature.com, we publish a group effort to outline a framework for studies with neural #organoids, #assembloids and transplantation. More details below 1/n
Reposted by Silvia Cappello
This detailed volume explores techniques for the study of neurogenic niches and neural lineage progression, specifically addressing major methodological challenges in studying neural stem cells (NSCs) and related cell populations, such as astrocytes, oligodendrocytes, and neurons.
March 13, 2025 at 2:09 PM
This detailed volume explores techniques for the study of neurogenic niches and neural lineage progression, specifically addressing major methodological challenges in studying neural stem cells (NSCs) and related cell populations, such as astrocytes, oligodendrocytes, and neurons.
...excited to be back home ☺️
📅 Next week, @silvianeuro.bsky.social from @bmc-lmu.bsky.social will share her research on early brain development, hosted by our director @binderlabmpip.bsky.social. The talk will take place at our MPI in Munich and is open to everyone!
🔗 All details here: www.psych.mpg.de/seminars
#neuroskyence
🔗 All details here: www.psych.mpg.de/seminars
#neuroskyence
March 9, 2025 at 3:55 PM
...excited to be back home ☺️
Aging activates escape of the silent X chromosome in the female mouse hippocampus | Science Advances www.science.org/doi/10.1126/...
Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
www.science.org
March 6, 2025 at 8:29 PM
Aging activates escape of the silent X chromosome in the female mouse hippocampus | Science Advances www.science.org/doi/10.1126/...
Reposted by Silvia Cappello
Three fantastic @science.org papers on convergent development & evolution of neurons + their connections in the bird &
mammalian pallia, by @kaessmannlab.bsky.social @steinaerts.bsky.social & Fernando García-Moreno.
Expertly synthesised by @giacomogattoni.bsky.social & Maria Antonietta Tosches 🧪🧠
mammalian pallia, by @kaessmannlab.bsky.social @steinaerts.bsky.social & Fernando García-Moreno.
Expertly synthesised by @giacomogattoni.bsky.social & Maria Antonietta Tosches 🧪🧠
Constrained roads to complex brains
Neural development and brain circuit evolution converged in birds and mammals
www.science.org
February 14, 2025 at 6:52 AM
Three fantastic @science.org papers on convergent development & evolution of neurons + their connections in the bird &
mammalian pallia, by @kaessmannlab.bsky.social @steinaerts.bsky.social & Fernando García-Moreno.
Expertly synthesised by @giacomogattoni.bsky.social & Maria Antonietta Tosches 🧪🧠
mammalian pallia, by @kaessmannlab.bsky.social @steinaerts.bsky.social & Fernando García-Moreno.
Expertly synthesised by @giacomogattoni.bsky.social & Maria Antonietta Tosches 🧪🧠
Reposted by Silvia Cappello
✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 20, 2025 at 8:11 AM
✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids | Science Advances www.science.org/doi/10.1126/...
Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids
Chronic exposure to glucocorticoids during brain development leads to priming of the inhibitory neuron lineages in organoids.
www.science.org
February 14, 2025 at 7:16 PM
Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids | Science Advances www.science.org/doi/10.1126/...
Reposted by Silvia Cappello
Why do people still use the term "Malformations of Cortical Development" (MCD)?
A malformation is a developmental process, there is no need for redundancy; development cannot be malformed.
"Cortical Malformations" (CM) alone does the job.
Just like the gulf of Mexico is the gulf of Mexico.
A malformation is a developmental process, there is no need for redundancy; development cannot be malformed.
"Cortical Malformations" (CM) alone does the job.
Just like the gulf of Mexico is the gulf of Mexico.
February 11, 2025 at 7:49 AM
Why do people still use the term "Malformations of Cortical Development" (MCD)?
A malformation is a developmental process, there is no need for redundancy; development cannot be malformed.
"Cortical Malformations" (CM) alone does the job.
Just like the gulf of Mexico is the gulf of Mexico.
A malformation is a developmental process, there is no need for redundancy; development cannot be malformed.
"Cortical Malformations" (CM) alone does the job.
Just like the gulf of Mexico is the gulf of Mexico.