To wish our friend and main O-glycan 3D structure contributor extraordinaire @silviadandrea.bsky.social all the best with the submission of her PhD thesis tomorrow, today's 🥄🍬 is dedicated to sialic acid 💜 with a mini 🧵 about all the wonderful functions Silvia worked on

In our contribution, @silviadandrea.bsky.social and I looked at the binding of GT1b (Siglec-10 fav buddy), which is polysialylated and has a very fancy structure 😍 MD simulations show how *multiple Arg* contribute to the recognition and binding, providing an atomistic perspective to experiment ⬇️ 2/3