While most of Europe was already off holidaying, the European Food Safety Authority quietly released its long-awaited scientific opinion on the welfare of mink, foxes, raccoon dogs and chinchillas kep...

Despite accumulating evidence that bat-derived coronaviruses often require intermediate hosts to facilitate transmission to humans1, the potential role of fur animals in zoonotic coronavirus spillovers has largely been overlooked2. Here we report the isolation and characterization of a novel mink respiratory coronavirus (MRCoV) from farmed minks with pneumonia. Notably, MRCoV uses angiotensin-converting enzyme 2 (ACE2) as a receptor and can infect mink, bat, monkey, and human cells. Cryo-electron microscopy analysis revealed that the MRCoV receptor-binding domain (RBD) binds to the same interface on ACE2 receptors as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RBD, despite exhibiting notable structural differences. We identify the key determinants on ACE2 and MRCoV RBD that confer efficient binding. HKU5-33S, a bat coronavirus closely related to MRCoV, utilizes ACE2 of bat Pipistrellus abramus and requires only two amino acid substitutions to adapt to mink ACE2. Furthermore, SARS-CoV-2 protease and polymerase inhibitors potently block MRCoV infection, indicating a potential therapeutic strategy. Collectively, these findings enhance the understanding of coronavirus receptor dynamics and highlight their zoonotic potential. Given the risks posed by fur farms as reservoirs for emerging pathogens, our study underscores the urgent need for enhanced surveillance to mitigate future coronavirus outbreaks.

Last year Channel 4 News reported on the Blackmore & Sparkford Vale Hunt, who were captured on drone cameras conducting what a court decided today was illegal hunting. Four men were found guilty of of...

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Fur farming represents an important hub of cross-species transmission for viral zoonoses.

Nature - More than five years on, studies suggest the animal is the most likely culprit, but other candidates haven't been ruled out.

More than five years on, studies suggest the animal is the most likely culprit, but other candidates haven't been ruled out.

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The role of farmed animals in the viral spillover from wild animals to humans is of growing importance. Between July and September of 2023 infectious disease outbreaks were reported on six Arctic f...