ShanYanLab
@shanyanlab.bsky.social
Professor, PI, Cell and Molecular Biologist. Study genome integrity and cancer etiology. Fun of Xenopus laevis. views=own
Reposted by ShanYanLab
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 30, 2025 at 8:41 PM
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by ShanYanLab
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Human RPA is an essential telomerase processivity factor for maintaining telomeres
Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical ...
www.science.org
October 30, 2025 at 10:07 PM
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Reposted by ShanYanLab
Our #EMGS2025 Sam Wilson Award Lecturer, Mark Hedglin is presenting a wonderful talk in Platform 1: DNA Repair, "Rad6 Is Dynamically Accessible for Activation Within the Rad6(Rad18)2 Complex: Mechanistic Insights into a Ubiquitin Cascade Critical for Human DNA Damage Tolerance"!
September 7, 2025 at 8:44 PM
Our #EMGS2025 Sam Wilson Award Lecturer, Mark Hedglin is presenting a wonderful talk in Platform 1: DNA Repair, "Rad6 Is Dynamically Accessible for Activation Within the Rad6(Rad18)2 Complex: Mechanistic Insights into a Ubiquitin Cascade Critical for Human DNA Damage Tolerance"!
Reposted by ShanYanLab
Our #EMGS2025 Hollaender Award Lecturer, Dr. Carole Yauk is speaking now!
Attendees: Don’t say you would’ve, could’ve, should’ve been there, and go see her talk, “The Eras Tour: A Genomic Journey Through the Evolution of Applied Genetic Toxicology.”
Attendees: Don’t say you would’ve, could’ve, should’ve been there, and go see her talk, “The Eras Tour: A Genomic Journey Through the Evolution of Applied Genetic Toxicology.”
September 7, 2025 at 9:02 PM
Our #EMGS2025 Hollaender Award Lecturer, Dr. Carole Yauk is speaking now!
Attendees: Don’t say you would’ve, could’ve, should’ve been there, and go see her talk, “The Eras Tour: A Genomic Journey Through the Evolution of Applied Genetic Toxicology.”
Attendees: Don’t say you would’ve, could’ve, should’ve been there, and go see her talk, “The Eras Tour: A Genomic Journey Through the Evolution of Applied Genetic Toxicology.”
2025 EMGS annual meeting
September 7, 2025 at 12:50 PM
2025 EMGS annual meeting