@sedakoyuncu.bsky.social
Postdoctoral researcher @CECAD, interested in #aging, #age-relateddiseases #proteostasis, #neurodegenerativediseases #proteinaggregation #ubiquitination #PTM
Reposted
Online now! @thevilchezlab.bsky.social @sedakoyuncu.bsky.social identify age-related hyperactivation of EPS8/RAC signaling in C.elegans as a driver of pathological protein aggregation, highlighting EPS8 and its regulators as potential therapeutic targets.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging
Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...
www.nature.com
September 4, 2025 at 11:01 AM
Online now! @thevilchezlab.bsky.social @sedakoyuncu.bsky.social identify age-related hyperactivation of EPS8/RAC signaling in C.elegans as a driver of pathological protein aggregation, highlighting EPS8 and its regulators as potential therapeutic targets.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Trilled to share our new work🥳We show that age-related hyperactivation of the EPS8/RAC signaling pathway drives protein aggregation and neurodegeneration — hallmarks of Huntington’s disease and ALS. #proteostasis #aging #neurodegenerativediseases
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
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www.nature.com/articles/s43...
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
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www.nature.com/articles/s43...
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging
Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...
www.nature.com
September 3, 2025 at 10:00 AM
Trilled to share our new work🥳We show that age-related hyperactivation of the EPS8/RAC signaling pathway drives protein aggregation and neurodegeneration — hallmarks of Huntington’s disease and ALS. #proteostasis #aging #neurodegenerativediseases
Happy to have contributed to this exciting work in collaboration with Prof. Dr. Irina Dudanova’s group! If you're interested in learning more about the role of Anle138b in regulating pathological phenotypes in mouse and cellular models of #Huntington’sDisease, check it out!
Happy to share our new preprint, where we find that anle138b reduces Huntingtin inclusions and improves disease phenotypes in #Huntington’sDisease models, showing its potential as an HD treatment.
Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social
Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social
March 22, 2025 at 10:30 AM
Happy to have contributed to this exciting work in collaboration with Prof. Dr. Irina Dudanova’s group! If you're interested in learning more about the role of Anle138b in regulating pathological phenotypes in mouse and cellular models of #Huntington’sDisease, check it out!