@sedakoyuncu.bsky.social
Postdoctoral researcher @CECAD, interested in #aging, #age-relateddiseases #proteostasis, #neurodegenerativediseases #proteinaggregation #ubiquitination #PTM
I’d like to thank everyone in the Vilchez Lab @thevilchezlab.bsky.social
and our amazing collaborators Nuria Flames, Yaiza Domínguez Canterla, and Rafael Alis for their enormous help and support throughout this work🙂🥳
and our amazing collaborators Nuria Flames, Yaiza Domínguez Canterla, and Rafael Alis for their enormous help and support throughout this work🙂🥳
September 3, 2025 at 10:01 AM
I’d like to thank everyone in the Vilchez Lab @thevilchezlab.bsky.social
and our amazing collaborators Nuria Flames, Yaiza Domínguez Canterla, and Rafael Alis for their enormous help and support throughout this work🙂🥳
and our amazing collaborators Nuria Flames, Yaiza Domínguez Canterla, and Rafael Alis for their enormous help and support throughout this work🙂🥳
Our findings highlight EPS8, RAC, and USP4 as promising targets for future therapies aimed at slowing or preventing disease progression in ALS, Huntington’s disease, and potentially other age-related brain disorders.
September 3, 2025 at 10:01 AM
Our findings highlight EPS8, RAC, and USP4 as promising targets for future therapies aimed at slowing or preventing disease progression in ALS, Huntington’s disease, and potentially other age-related brain disorders.
By reducing EPS8/RAC activity, we were able to prevent the buildup of toxic protein aggregates and preserve neuronal function in C. elegans models of Huntington’s disease and ALS. Furthermore, we discovered that the deubiquitinating enzyme USP4 regulates EPS8 during aging.
September 3, 2025 at 10:00 AM
By reducing EPS8/RAC activity, we were able to prevent the buildup of toxic protein aggregates and preserve neuronal function in C. elegans models of Huntington’s disease and ALS. Furthermore, we discovered that the deubiquitinating enzyme USP4 regulates EPS8 during aging.