SecureBio, Inc.
@securebio.org
Nucleic Acid Observatory updates:
- Major wastewater surveillance scaling: expanded to 31 sampling sites across 19 cities.
- Zephyr swab program scaling, now 400-800 swabs per week.
- New team members that lead response, wet-lab, and partnerships work.
- Major wastewater surveillance scaling: expanded to 31 sampling sites across 19 cities.
- Zephyr swab program scaling, now 400-800 swabs per week.
- New team members that lead response, wet-lab, and partnerships work.
November 12, 2025 at 6:30 PM
Nucleic Acid Observatory updates:
- Major wastewater surveillance scaling: expanded to 31 sampling sites across 19 cities.
- Zephyr swab program scaling, now 400-800 swabs per week.
- New team members that lead response, wet-lab, and partnerships work.
- Major wastewater surveillance scaling: expanded to 31 sampling sites across 19 cities.
- Zephyr swab program scaling, now 400-800 swabs per week.
- New team members that lead response, wet-lab, and partnerships work.
At the Nucleic Acid Observatory, we usually rely on Illumina technology for wastewater viral sequencing.
Recently we benchmarked different Oxford Nanopore sequencing workflows.
In a new post, we examine these workflows in detail and explain why one emerges as our top choice.
Recently we benchmarked different Oxford Nanopore sequencing workflows.
In a new post, we examine these workflows in detail and explain why one emerges as our top choice.
Benchmarking three ONT-based workflows for untargeted sequencing of RNA viruses in wastewater
At the NAO, we use short-read Illumina technology as the gold standard for untargeted sequencing of RNA viruses in wastewater because it provide...
naobservatory.org
September 16, 2025 at 5:24 PM
At the Nucleic Acid Observatory, we usually rely on Illumina technology for wastewater viral sequencing.
Recently we benchmarked different Oxford Nanopore sequencing workflows.
In a new post, we examine these workflows in detail and explain why one emerges as our top choice.
Recently we benchmarked different Oxford Nanopore sequencing workflows.
In a new post, we examine these workflows in detail and explain why one emerges as our top choice.
SecureBio’s NAO detection system flags suspicious reads, but doesn't recover the surrounding genome.
We can recover these genomes with our outward assembly pipeline.
We recently tested outward assembly on a flagged SARS-CoV-2/plasmid construct – it did extremely well!
We can recover these genomes with our outward assembly pipeline.
We recently tested outward assembly on a flagged SARS-CoV-2/plasmid construct – it did extremely well!
July 25, 2025 at 4:32 PM
SecureBio’s NAO detection system flags suspicious reads, but doesn't recover the surrounding genome.
We can recover these genomes with our outward assembly pipeline.
We recently tested outward assembly on a flagged SARS-CoV-2/plasmid construct – it did extremely well!
We can recover these genomes with our outward assembly pipeline.
We recently tested outward assembly on a flagged SARS-CoV-2/plasmid construct – it did extremely well!
Nucleic Acid Observatory updates:
- We’ve further increased our sequencing capacity, producing 487B read pairs.
- Our partners created dashboards that summarize which pathogens we routinely see in wastewater.
- We’ve been scaling up our Boston-based swab sampling program.
- We’ve further increased our sequencing capacity, producing 487B read pairs.
- Our partners created dashboards that summarize which pathogens we routinely see in wastewater.
- We’ve been scaling up our Boston-based swab sampling program.
July 10, 2025 at 9:31 PM
Nucleic Acid Observatory updates:
- We’ve further increased our sequencing capacity, producing 487B read pairs.
- Our partners created dashboards that summarize which pathogens we routinely see in wastewater.
- We’ve been scaling up our Boston-based swab sampling program.
- We’ve further increased our sequencing capacity, producing 487B read pairs.
- Our partners created dashboards that summarize which pathogens we routinely see in wastewater.
- We’ve been scaling up our Boston-based swab sampling program.
At the NAO, we’ve created new estimates on how well wastewater sequencing detects different pathogens.
SARS-CoV-2 is again highly detectable, but common cold viruses are harder to detect.
We will use this research to compare wastewater sequencing to other detection strategies.
SARS-CoV-2 is again highly detectable, but common cold viruses are harder to detect.
We will use this research to compare wastewater sequencing to other detection strategies.
June 26, 2025 at 1:50 PM
At the NAO, we’ve created new estimates on how well wastewater sequencing detects different pathogens.
SARS-CoV-2 is again highly detectable, but common cold viruses are harder to detect.
We will use this research to compare wastewater sequencing to other detection strategies.
SARS-CoV-2 is again highly detectable, but common cold viruses are harder to detect.
We will use this research to compare wastewater sequencing to other detection strategies.
SecureBio, partnering with Ginkgo Biosecurity will host an evening event on how to accelerate biosecurity on Thursday, July 31st, from 6:00-8:30 pm, in Boston (sign-up link in the next post).
June 18, 2025 at 7:06 PM
SecureBio, partnering with Ginkgo Biosecurity will host an evening event on how to accelerate biosecurity on Thursday, July 31st, from 6:00-8:30 pm, in Boston (sign-up link in the next post).
New Substack post from the Executive Director – an overview of some recent major accomplishments by our AI and biosurveillance teams, and some organizational updates.
substack.com/home/post/p-...
substack.com/home/post/p-...
Letter from the Executive Director
Some recent organizational updates
substack.com
May 23, 2025 at 3:38 PM
New Substack post from the Executive Director – an overview of some recent major accomplishments by our AI and biosurveillance teams, and some organizational updates.
substack.com/home/post/p-...
substack.com/home/post/p-...
SecureBio recently launched a Substack! You can subscribe here: securebio.substack.com
Our Substack lets you get blog posts from the Nucleic Acid Observatory and AIxBio team directly to your inbox.
Our Substack lets you get blog posts from the Nucleic Acid Observatory and AIxBio team directly to your inbox.
SecureBio | Substack
Click to read SecureBio, a Substack publication. Launched a month ago.
securebio.substack.com
May 20, 2025 at 6:50 PM
SecureBio recently launched a Substack! You can subscribe here: securebio.substack.com
Our Substack lets you get blog posts from the Nucleic Acid Observatory and AIxBio team directly to your inbox.
Our Substack lets you get blog posts from the Nucleic Acid Observatory and AIxBio team directly to your inbox.
The medical system collects millions of samples for medical diagnoses. After testing, leftover samples could be repurposed for early pathogen detection.
@jefftk.com and @lennijusten.bsky.social explore sequencing pooled lab discards: naobservatory.org/blog/lab-dis...
@jefftk.com and @lennijusten.bsky.social explore sequencing pooled lab discards: naobservatory.org/blog/lab-dis...
Pooled Lab Discards for Pathogen Detection
We’re excited about sampling strategies that can cheaply access many individual samples, approaching the coverage of municipal wastewater while ...
naobservatory.org
May 16, 2025 at 4:06 PM
The medical system collects millions of samples for medical diagnoses. After testing, leftover samples could be repurposed for early pathogen detection.
@jefftk.com and @lennijusten.bsky.social explore sequencing pooled lab discards: naobservatory.org/blog/lab-dis...
@jefftk.com and @lennijusten.bsky.social explore sequencing pooled lab discards: naobservatory.org/blog/lab-dis...
At the Nucleic Acid Observatory, we do a *lot* of wastewater metagenomic sequencing—currently ~25B read pairs weekly, soon scaling to 75B.
Both finding suspicious sequences and understanding their genomic context are crucial challenges in our pathogen monitoring. 1/4
Both finding suspicious sequences and understanding their genomic context are crucial challenges in our pathogen monitoring. 1/4
April 25, 2025 at 5:28 PM
At the Nucleic Acid Observatory, we do a *lot* of wastewater metagenomic sequencing—currently ~25B read pairs weekly, soon scaling to 75B.
Both finding suspicious sequences and understanding their genomic context are crucial challenges in our pathogen monitoring. 1/4
Both finding suspicious sequences and understanding their genomic context are crucial challenges in our pathogen monitoring. 1/4
Can AIs provide expert-level troubleshooting assistance for work with viruses?
We built a new benchmark to answer that question.
To our surprise, we found that leading models outperform the vast majority of practicing virologists we sampled. 🧵 1/13
We built a new benchmark to answer that question.
To our surprise, we found that leading models outperform the vast majority of practicing virologists we sampled. 🧵 1/13
April 23, 2025 at 9:51 PM
Can AIs provide expert-level troubleshooting assistance for work with viruses?
We built a new benchmark to answer that question.
To our surprise, we found that leading models outperform the vast majority of practicing virologists we sampled. 🧵 1/13
We built a new benchmark to answer that question.
To our surprise, we found that leading models outperform the vast majority of practicing virologists we sampled. 🧵 1/13