Stefano Crespi
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screspi.bsky.social
Stefano Crespi
@screspi.bsky.social
Assistant Professor in Organic Photochemistry at Uppsala University
Editor of the Journal of Molecular Structure
Reposted by Stefano Crespi
We developed an AND-gated chemiluminescent photosensitizer that only generates light inside tumor cells, activating under 2 cancer cell-specific conditions.
Many thanks to Wenwu Peng @pengww.bsky.social from Seah Ling Kuan's group @seahling.bsky.social & our collaborators! shorturl.at/uXTg3
Autonomous Activation of a Gated Chemiluminescent Photosensitizer Enables Targeted Photodynamic Therapy in Tumor Cells
Chemiluminescence-based photodynamic therapy (CLPDT) offers a promising solution to the light penetration limits of traditional PDT. However, it lacks spatiotemporal control. Intracellularly activated...
pubs.acs.org
July 24, 2025 at 12:21 PM
Our pipeline to compute thermal barriers of photoswitches💡 is out!🥳 We especially focused on NBDs for MOST🔋 and imines, but also stilbenes and DAEs. Try it out! You need just chemdraws and freeware to get libraries computed

doi.org/10.1002/cptc...
Semi‐Automated Pipeline for Transition State Search of Molecular Photoswitches
A semi-automated pipeline for the transition state search of molecular switches (PiTS3) is reported, which facilitates the search, optimization, and conformational analysis of transition states of ph...
doi.org
July 21, 2025 at 12:22 PM
Reposted by Stefano Crespi
Over the moon that the first paper from Anja's studies on metal chelate rotaxanes is now online in @angewandtechemie.bsky.social. doi.org/10.1002/anie...
Massive congratulations Anja,
@daisypooler.bsky.social Huseyn, Monika and @screspi.bsky.social 🥳🎉🎊🍀🥃

Thread below --》
Modulation of Lanthanide Luminescence with the Mechanical Bond: Antenna‐Emitter Confinement in a Compact [2]Rotaxane
Luminescent emitters based on lanthanide ions are of ubiquitous importance in the biological sciences, but typically need sensitisation from a covalently attached adjacent chromophore – an “antenna” ....
doi.org
June 5, 2025 at 4:12 AM
Mati's work on aldehyde and COOH effect on HTIs is out! Nice collaboration with the Ott group for the inclusion and switching of HTIs in MOFs💡 doi.org/10.1002/chem...
The Effect of Aldehyde and Carboxylic Acid Substitution on the Isomerization of Hemithioindigo Photoswitches
Hemithioindigo (HTI) photoswitches exhibit robust photoisomerization under visible light and relatively high thermal bistability. In this work, we report various modifications of the HTI core, namely....
doi.org
April 19, 2025 at 7:40 AM
Reposted by Stefano Crespi
Tert-butylamine as a labile ligand and base enables cross-coupling reactions with various nucleophile classes. A great collaboration of Jonas with the Sigman lab and Gschwind group
#ChemSky #ChemCollabs #photocatalysis

doi.org/10.1021/acsc...
Cross-Coupling Reactions with Nickel, Visible Light, and tert-Butylamine as a Bifunctional Additive
Transition metal catalysis is crucial for the synthesis of complex molecules, with ligands and bases playing a pivotal role in optimizing cross-coupling reactions. Despite advancements in ligand desig...
doi.org
January 16, 2025 at 4:16 PM
Reposted by Stefano Crespi
Reposting this #molswitch #molmachine starter pack. If you want to be included in it, please let me know
go.bsky.app/EwimNbK
January 16, 2025 at 3:10 PM
Reposted by Stefano Crespi
Here is a tentative Supramolecular Chemistry starter kit. Please let me know if you wish to be added ! #ChemSky
go.bsky.app/RjRgi6n
January 6, 2025 at 5:16 PM
Great to be highlighted by @chemistryviews.bsky.social! Go pnictogen switches 😀 💡
Molecular Switch with a Variety of External Triggers:
Reversible molecular switching of a phosphaethene polyaromatic hydrocarbon by irradiation, metal coordination, or deprotonation
www.chemistryviews.org/molecular-sw...
December 26, 2024 at 11:07 AM
Reposted by Stefano Crespi
Molecular Switch with a Variety of External Triggers:
Reversible molecular switching of a phosphaethene polyaromatic hydrocarbon by irradiation, metal coordination, or deprotonation
www.chemistryviews.org/molecular-sw...
December 26, 2024 at 6:32 AM
Another C=P switch💡🅿️, this time with a metal twist 😀 great collaboration with @orthaberlab.bsky.social
December 24, 2024 at 12:29 PM
Reposted by Stefano Crespi
December 13, 2024 at 3:51 PM
Reposted by Stefano Crespi
Our OrgChem Starter Pack is growing with already 122 entries, but we will start a volume 2 if we go over the 150 limit!
go.bsky.app/NSEFPFJ
December 5, 2024 at 6:37 PM
Reposted by Stefano Crespi
Absolutely delighted to see the light of this collaborative work between the @screspi.bsky.social team and our group, with all the spectroscopy help.
Demonstrating degenerate isomerisation of phosphaalkenes using NMR spectroscopy #chemsky #NMRchat
onlinelibrary.wiley.com/doi/10.1002/...
Probing the Hidden Photoisomerization of a Symmetric Phosphaalkene Switch
In this study, we present the synthesis and analysis of a novel, air-stable, and solvent-resistant phosphaalkene switch. Using this symmetric switch, we have demonstrated degenerate photoisomerizatio...
onlinelibrary.wiley.com
December 4, 2024 at 7:47 AM
Hey #Chemsky! For my first post, I am hyped to share our latest efforts on main group C=P photoswitches💡, where we explored their isomerization mechanisms and observed experimentally symmetric molecules switch via NMR!🧲🔍a great international collaboration! onlinelibrary.wiley.com/doi/10.1002/...
Probing the Hidden Photoisomerization of a Symmetric Phosphaalkene Switch
In this study, we present the synthesis and analysis of a novel, air-stable, and solvent-resistant phosphaalkene switch. Using this symmetric switch, we have demonstrated degenerate photoisomerizatio...
onlinelibrary.wiley.com
December 3, 2024 at 1:33 PM
Reposted by Stefano Crespi
You ever have one of those amazing weeks when everything clicks in your multiple roles as an academic PI- scientist, mentor, parent, partner, colleague, psychologist, fundraiser, salesperson?

(Yeah, me neither.)

But screwing up each of these roles takes special talent.

(I am that talented.)
November 26, 2024 at 12:41 AM
Reposted by Stefano Crespi
What better first post than to advertise this position. Come join our group!

Our group is recruiting a postdoctoral researcher for a project on reactive machine learning potentials. Reposts and spreading the word to interested people in your network appreciated!

jobs.ethz.ch/job/view/JOP...
Postdoc position in reactive machine learning potentials
jobs.ethz.ch
November 21, 2024 at 12:43 PM
Reposted by Stefano Crespi
Here is a starter pack for folks into tiny switches and machines. I am sure I missed many. Please let me know if you should be included and I will add you
go.bsky.app/EwimNbK
November 21, 2024 at 4:28 PM
Reposted by Stefano Crespi
Would you like to spend the next summer in beautiful Hamburg doing some uranium chemistry? If you're an undergraduate student from the UK, Ireland or North America, you have 11 days left to apply for two fully funded research internships via the DAAD: www.daad.de/rise/en/rise... #chemsky
November 19, 2024 at 2:19 PM