Sophia Levis, MD, PhD
@sclevis.bsky.social
PGY-1 UC Irvine Psychiatry | MD/PhD from UC Irvine MSTP | NIDA NRSA Fellow | Interested in early life adversity, reward circuits, addiction | sc_levis on Twitter
Reposted by Sophia Levis, MD, PhD
Re-sharing over here the final chapter of my PhD now online as part of a special issue of Addiction Neuroscience on stress and addiction! We explore the link between adversity, addiction, and the role of delta opioid receptors in mediating that link:
Opioid drug seeking after early-life adversity: a role for delta opioid receptors
Opioid use disorder (OUD) is associated with a history of early-life adversity (ELA), an association that is particularly strong in women. In a rodent…
www.sciencedirect.com
December 4, 2024 at 5:30 AM
Re-sharing over here the final chapter of my PhD now online as part of a special issue of Addiction Neuroscience on stress and addiction! We explore the link between adversity, addiction, and the role of delta opioid receptors in mediating that link:
Re-sharing over here the final chapter of my PhD now online as part of a special issue of Addiction Neuroscience on stress and addiction! We explore the link between adversity, addiction, and the role of delta opioid receptors in mediating that link:
Opioid drug seeking after early-life adversity: a role for delta opioid receptors
Opioid use disorder (OUD) is associated with a history of early-life adversity (ELA), an association that is particularly strong in women. In a rodent…
www.sciencedirect.com
December 4, 2024 at 5:30 AM
Re-sharing over here the final chapter of my PhD now online as part of a special issue of Addiction Neuroscience on stress and addiction! We explore the link between adversity, addiction, and the role of delta opioid receptors in mediating that link:
Reposted by Sophia Levis, MD, PhD
Our study on ketamine's effects on neural self-other-distinction is finally out! 🥳
This is the first really big project from my lab, so I am extra happy about this one 🤩.
#neuroskyence
#PsychSciSky
#AcademicSky
#philsci
This is the first really big project from my lab, so I am extra happy about this one 🤩.
#neuroskyence
#PsychSciSky
#AcademicSky
#philsci
Excited that our study on ketamine & self- and other-touch has now been published! doi.org/10.1038/s413...
Touch plays a major role in our sense of self and ketamine can disturb our sense of self. So, what happens with the processing of self- and other-generated touch when we receive ketamine? 🧵
Touch plays a major role in our sense of self and ketamine can disturb our sense of self. So, what happens with the processing of self- and other-generated touch when we receive ketamine? 🧵
Ketamine reduces the neural distinction between self- and other-produced affective touch: a randomized double-blind placebo-controlled study - Neuropsychopharmacology
Neuropsychopharmacology - Ketamine reduces the neural distinction between self- and other-produced affective touch: a randomized double-blind placebo-controlled study
doi.org
June 27, 2024 at 3:10 PM
Our study on ketamine's effects on neural self-other-distinction is finally out! 🥳
This is the first really big project from my lab, so I am extra happy about this one 🤩.
#neuroskyence
#PsychSciSky
#AcademicSky
#philsci
This is the first really big project from my lab, so I am extra happy about this one 🤩.
#neuroskyence
#PsychSciSky
#AcademicSky
#philsci
Reposted by Sophia Levis, MD, PhD
Denver gave people experiencing homelessness $1,000 a month.
Results showed that close to half of the participants secured housing, and nearly $600K saved in public service costs due to fewer ER visits & jail stays. They also saw improved mental health.
Results showed that close to half of the participants secured housing, and nearly $600K saved in public service costs due to fewer ER visits & jail stays. They also saw improved mental health.
Denver gave people experiencing homelessness $1,000 a month. A year later, nearly half of participants had housing.
Participants in Denver's basic income program received up to $1,000 a month. They became more housing secure and landed full-time jobs.
www.yahoo.com
June 25, 2024 at 9:25 PM
Denver gave people experiencing homelessness $1,000 a month.
Results showed that close to half of the participants secured housing, and nearly $600K saved in public service costs due to fewer ER visits & jail stays. They also saw improved mental health.
Results showed that close to half of the participants secured housing, and nearly $600K saved in public service costs due to fewer ER visits & jail stays. They also saw improved mental health.
Reposted by Sophia Levis, MD, PhD
The five stages of academic writing:
1. Procrastination
2. Panic
3. Caffeine overdose
4. Submitting a barely coherent mess
5. Swearing to do it differently next time
#academicsky
1. Procrastination
2. Panic
3. Caffeine overdose
4. Submitting a barely coherent mess
5. Swearing to do it differently next time
#academicsky
May 26, 2024 at 5:38 PM
The five stages of academic writing:
1. Procrastination
2. Panic
3. Caffeine overdose
4. Submitting a barely coherent mess
5. Swearing to do it differently next time
#academicsky
1. Procrastination
2. Panic
3. Caffeine overdose
4. Submitting a barely coherent mess
5. Swearing to do it differently next time
#academicsky
Reposted by Sophia Levis, MD, PhD
Some cool work showing negative valence of MOR-expressing neurons in the CeA during fentanyl withdrawal.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Distinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement - Nature
Experiments using fentanyl treatment of mice show that µ-opioid receptors mediate positive reinforcement in the ventral tegmental area and negative reinforcement in central amygdala, thereby identifyi...
www.nature.com
May 26, 2024 at 3:04 PM
Some cool work showing negative valence of MOR-expressing neurons in the CeA during fentanyl withdrawal.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sophia Levis, MD, PhD
Nice article pushing back on pop culture versions of dopamine
Featuring an all star dopamine scientist cast ⭐ - happy to see all these folks contributing!
www.vox.com/future-perfe...
Featuring an all star dopamine scientist cast ⭐ - happy to see all these folks contributing!
www.vox.com/future-perfe...
Dopamine, explained
Dopamine detoxing, hacking, and fasting: Is any of it real?
www.vox.com
May 22, 2024 at 4:21 PM
Nice article pushing back on pop culture versions of dopamine
Featuring an all star dopamine scientist cast ⭐ - happy to see all these folks contributing!
www.vox.com/future-perfe...
Featuring an all star dopamine scientist cast ⭐ - happy to see all these folks contributing!
www.vox.com/future-perfe...
Reposted by Sophia Levis, MD, PhD
Very happy to announce our paper!
"Sex mechanisms as nonbinary influences on cognitive diversity"
A pleasure to contribute to this special issue of Hormones and Behavior about how to be less binary and more inclusive in behavioral and cognitive neuroscience
www.sciencedirect.com/science/arti...
"Sex mechanisms as nonbinary influences on cognitive diversity"
A pleasure to contribute to this special issue of Hormones and Behavior about how to be less binary and more inclusive in behavioral and cognitive neuroscience
www.sciencedirect.com/science/arti...
May 20, 2024 at 7:26 PM
Very happy to announce our paper!
"Sex mechanisms as nonbinary influences on cognitive diversity"
A pleasure to contribute to this special issue of Hormones and Behavior about how to be less binary and more inclusive in behavioral and cognitive neuroscience
www.sciencedirect.com/science/arti...
"Sex mechanisms as nonbinary influences on cognitive diversity"
A pleasure to contribute to this special issue of Hormones and Behavior about how to be less binary and more inclusive in behavioral and cognitive neuroscience
www.sciencedirect.com/science/arti...
After 8 long years, finally get to call myself a double doc! So grateful to my mentors, family, and my MSTP cohort, who are some of the most amazing and inspiring physician-scientists I know! 🧪🩺🧠
May 20, 2024 at 2:43 AM
After 8 long years, finally get to call myself a double doc! So grateful to my mentors, family, and my MSTP cohort, who are some of the most amazing and inspiring physician-scientists I know! 🧪🩺🧠
Very honored to have received the Meyskens Family research award and the department of Psychiatry outstanding graduating student award! Such an honor to be recognized among so many of my accomplished peers, and extra proud to have my family with me tonight to help celebrate! #medsky
May 18, 2024 at 5:19 AM
Very honored to have received the Meyskens Family research award and the department of Psychiatry outstanding graduating student award! Such an honor to be recognized among so many of my accomplished peers, and extra proud to have my family with me tonight to help celebrate! #medsky
Reposted by Sophia Levis, MD, PhD
I’m looking for more post-docs to join our team at UCLA ☀️ Please share with your 🧠 networks recruit.apo.ucla.edu/JPF09330
Postdoctoral Scholar
University of California, Los Angeles is hiring. Apply now!
recruit.apo.ucla.edu
April 5, 2024 at 2:59 AM
I’m looking for more post-docs to join our team at UCLA ☀️ Please share with your 🧠 networks recruit.apo.ucla.edu/JPF09330
Reposted by Sophia Levis, MD, PhD
What I think I wrote vs what I realize I wrote when I’m editing
March 27, 2024 at 11:47 PM
What I think I wrote vs what I realize I wrote when I’m editing
Reposted by Sophia Levis, MD, PhD
🧠 hello #neuroskyence! happy to share my early career commentary in neuropsychopharmacology, highlighting the importance of understanding sex hormones for understanding the brain: www.nature.com/articles/s41...
February 19, 2024 at 7:06 PM
🧠 hello #neuroskyence! happy to share my early career commentary in neuropsychopharmacology, highlighting the importance of understanding sex hormones for understanding the brain: www.nature.com/articles/s41...
Reposted by Sophia Levis, MD, PhD
The first draft is for telling yourself the story, revisions are for telling your readers.
I don't like "Your first draft will be shitty" as advice, because it's a really negative framing.
I prefer, "You have the freedom to be messy creating your first draft."
Anyone crafter knows what their room looks like mid-creation. Writers should be as free to be as exhuberent and messy.
I prefer, "You have the freedom to be messy creating your first draft."
Anyone crafter knows what their room looks like mid-creation. Writers should be as free to be as exhuberent and messy.
February 16, 2024 at 3:37 PM
The first draft is for telling yourself the story, revisions are for telling your readers.
Reposted by Sophia Levis, MD, PhD
Excited to share a new paper w Dani Bassett on "Causation in neuroscience: keeping mechanism meaningful" in Nature Reviews Neuroscience
We explore different meanings of mechanism in the field, the challenges this presents & how to move forward. 🧠
www.nature.com/articles/s41...
We explore different meanings of mechanism in the field, the challenges this presents & how to move forward. 🧠
www.nature.com/articles/s41...
Causation in neuroscience: keeping mechanism meaningful - Nature Reviews Neuroscience
‘Mechanism’ is a frequently used causal concept in neuroscience but can have different meanings that are often not specified. In this Review, Ross and Bassett explore these different meanings and ...
www.nature.com
January 12, 2024 at 3:49 PM
Excited to share a new paper w Dani Bassett on "Causation in neuroscience: keeping mechanism meaningful" in Nature Reviews Neuroscience
We explore different meanings of mechanism in the field, the challenges this presents & how to move forward. 🧠
www.nature.com/articles/s41...
We explore different meanings of mechanism in the field, the challenges this presents & how to move forward. 🧠
www.nature.com/articles/s41...
Had my final residency interview today and am just so excited to be one small step closer to becoming a psychiatrist physician-scientist! Now back to the wards... #medsky #womeninstem #neuroskyence #addictionsci
January 11, 2024 at 3:06 AM
Had my final residency interview today and am just so excited to be one small step closer to becoming a psychiatrist physician-scientist! Now back to the wards... #medsky #womeninstem #neuroskyence #addictionsci
Reposted by Sophia Levis, MD, PhD
New year, new preprint! Cued invigoration of reward seeking promotes sustained population coding in the BLA, which is disrupted by OFC inactivation. Consistent with the notion that BLA represents motivational states.
Basolateral amygdala population coding of a cued reward seeking state depends on orbitofrontal cortex https://www.biorxiv.org/content/10.1101/2023.12.31.573789v1
Basolateral amygdala population coding of a cued reward seeking state depends on orbitofrontal cortex https://www.biorxiv.org/content/10.1101/2023.12.31.573789v1
Basolateral amygdala (BLA) neuronal responses to conditioned stimuli are closely linked to the expre
www.biorxiv.org
January 2, 2024 at 3:01 PM
New year, new preprint! Cued invigoration of reward seeking promotes sustained population coding in the BLA, which is disrupted by OFC inactivation. Consistent with the notion that BLA represents motivational states.
Reposted by Sophia Levis, MD, PhD
Our latest pub delves into the complex link between obstetric procedures OUD in women, highlighting how some procedures (e.g., ectopic pregnancy, cesarean) have a higher risk for OUD than others (e.g., vaginal delivery). bit.ly/OUDandObstet...
January 2, 2024 at 4:44 PM
Our latest pub delves into the complex link between obstetric procedures OUD in women, highlighting how some procedures (e.g., ectopic pregnancy, cesarean) have a higher risk for OUD than others (e.g., vaginal delivery). bit.ly/OUDandObstet...
Reposted by Sophia Levis, MD, PhD
December 29, 2023 at 4:26 PM
Proud of myself for getting two manuscripts submitted just under the 2023 wire! Stay tuned for some cool 🧪🩺🧠 stuff coming out in 2024! #medsky #neuroskyence #addictionsci
December 29, 2023 at 5:49 AM
Proud of myself for getting two manuscripts submitted just under the 2023 wire! Stay tuned for some cool 🧪🩺🧠 stuff coming out in 2024! #medsky #neuroskyence #addictionsci
Reposted by Sophia Levis, MD, PhD
Summer Undergraduate Research Fellowship (SURF) are invaluable opportunities for undergraduates to gain research experience. Join Black In Neuro on Friday, Jan. 12, 2024 at 1 PM ET for an information session with universities on the SURF application process. Register now! t.co/MuYLHgnG85 🟦🧠 🧪
December 26, 2023 at 5:37 PM
Summer Undergraduate Research Fellowship (SURF) are invaluable opportunities for undergraduates to gain research experience. Join Black In Neuro on Friday, Jan. 12, 2024 at 1 PM ET for an information session with universities on the SURF application process. Register now! t.co/MuYLHgnG85 🟦🧠 🧪
Merry Christmas ya filthy animals
December 26, 2023 at 3:24 AM
Merry Christmas ya filthy animals