Jack Schofield
@schofiej.bsky.social
PhD Student at CÚRAM, University of Galway. Researching glycosylation in the human cornea 👁️
Reposted by Jack Schofield
Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
October 6, 2025 at 1:36 PM
Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Reposted by Jack Schofield
Another piece of the #glycoRNA puzzle revealed by @raflynn5.bsky.social and @vijayrathinam.bsky.social!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
www.nature.com
August 19, 2025 at 7:43 PM
Another piece of the #glycoRNA puzzle revealed by @raflynn5.bsky.social and @vijayrathinam.bsky.social!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jack Schofield
Another interesting paper from Pascal Gagneux. The sialome of human retina is altered in AMD, which may affect binding of complement factor F, and, consequently, alternative complement pathway regulation.
tinyurl.com/2fzw4wxk
#glycotime
tinyurl.com/2fzw4wxk
#glycotime
July 9, 2025 at 12:04 PM
Another interesting paper from Pascal Gagneux. The sialome of human retina is altered in AMD, which may affect binding of complement factor F, and, consequently, alternative complement pathway regulation.
tinyurl.com/2fzw4wxk
#glycotime
tinyurl.com/2fzw4wxk
#glycotime