Satoshi Yoshiji, MD, PhD
@satoshiyoshiji.bsky.social
Assistant Prof & PI at McGill University (@mcgill.ca) using human genetics & multi-omics for drug discovery | Endocrinologist | PhD at McGill & KyotoU | Visiting Scholar at the Broad Institute of MIT and Harvard & MGH
Twitter: https://x.com/satoshiyoshiji
Twitter: https://x.com/satoshiyoshiji
Pinned
Just started on bsky!
My lab at McGill uses genomics and proteomics to understand human diseases. Check out our preprint!
📣Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targets:
www.medrxiv.org/content/10.1...
My lab at McGill uses genomics and proteomics to understand human diseases. Check out our preprint!
📣Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targets:
www.medrxiv.org/content/10.1...
Our commentary is out in Diabetes!
• MODY panels are undergoing refinement in the population-scale genetics era.
• We discuss how the Exeter team provides strong evidence for NEUROD1 and PDX1, but not for APPL1 or WFS1, using data from UK Biobank and gnomAD.
diabetesjournals.org/diabetes/art...
• MODY panels are undergoing refinement in the population-scale genetics era.
• We discuss how the Exeter team provides strong evidence for NEUROD1 and PDX1, but not for APPL1 or WFS1, using data from UK Biobank and gnomAD.
diabetesjournals.org/diabetes/art...
October 21, 2025 at 2:21 PM
Our commentary is out in Diabetes!
• MODY panels are undergoing refinement in the population-scale genetics era.
• We discuss how the Exeter team provides strong evidence for NEUROD1 and PDX1, but not for APPL1 or WFS1, using data from UK Biobank and gnomAD.
diabetesjournals.org/diabetes/art...
• MODY panels are undergoing refinement in the population-scale genetics era.
• We discuss how the Exeter team provides strong evidence for NEUROD1 and PDX1, but not for APPL1 or WFS1, using data from UK Biobank and gnomAD.
diabetesjournals.org/diabetes/art...
Join us today at 4:40 pm at the Festival of Genomics & Biodata (@fogenomics.bsky.social) in Boston to explore how proteomics and genomics drive drug-target discovery!
June 24, 2025 at 3:39 PM
Join us today at 4:40 pm at the Festival of Genomics & Biodata (@fogenomics.bsky.social) in Boston to explore how proteomics and genomics drive drug-target discovery!
Reposted by Satoshi Yoshiji, MD, PhD
Canada’s federal scholarship is changing for the better! New scheme:
• Master’s: 1yr, $27K
• Doctoral: 3yrs, $40K/yr
• Postdoc: 2yrs, $70K/yr
300, 1200, 220 more awards added, respectively.
Plus, international PhD students & postdocs now eligible!
Details: www.nserc-crsng.gc.ca/NewsDetail-D...
• Master’s: 1yr, $27K
• Doctoral: 3yrs, $40K/yr
• Postdoc: 2yrs, $70K/yr
300, 1200, 220 more awards added, respectively.
Plus, international PhD students & postdocs now eligible!
Details: www.nserc-crsng.gc.ca/NewsDetail-D...
NSERC - Latest News - Launch of the new Harmonized Tri-agency Scholarship and Fellowship programs
As announced in Budget 2024, the scholarship and fellowship programs administered by the three federal research funding agencies – the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council (NSERC), and the Social Sciences and Humanities Research Council (SSHRC) – have been streamlined into a new harmonized talent program called the Canada Research Training Awards Suite (CRTAS) that will open for applications in summer 2025.
www.nserc-crsng.gc.ca
March 18, 2025 at 3:53 PM
Canada’s federal scholarship is changing for the better! New scheme:
• Master’s: 1yr, $27K
• Doctoral: 3yrs, $40K/yr
• Postdoc: 2yrs, $70K/yr
300, 1200, 220 more awards added, respectively.
Plus, international PhD students & postdocs now eligible!
Details: www.nserc-crsng.gc.ca/NewsDetail-D...
• Master’s: 1yr, $27K
• Doctoral: 3yrs, $40K/yr
• Postdoc: 2yrs, $70K/yr
300, 1200, 220 more awards added, respectively.
Plus, international PhD students & postdocs now eligible!
Details: www.nserc-crsng.gc.ca/NewsDetail-D...
Reposted by Satoshi Yoshiji, MD, PhD
McGill’s MSc & PhD in Human Genetics Program is accepting applications for Fall 2025 from Canadian citizens & permanent residents (Deadline: May 31). International students are encouraged to apply for Winter 2026 (Deadline: Oct 15).
Join our vibrant research community!
www.mcgill.ca/humangenetic...
Join our vibrant research community!
www.mcgill.ca/humangenetic...
Application Deadlines
MSc in Genetic Counselling Program (Non-Thesis) Fall Winter Non-Canadian Citizens (International) January 01 N/A Canadian Citizens & Permanent Residents in Canada January 01 N/A * The M.Sc. ...
www.mcgill.ca
March 17, 2025 at 2:18 PM
McGill’s MSc & PhD in Human Genetics Program is accepting applications for Fall 2025 from Canadian citizens & permanent residents (Deadline: May 31). International students are encouraged to apply for Winter 2026 (Deadline: Oct 15).
Join our vibrant research community!
www.mcgill.ca/humangenetic...
Join our vibrant research community!
www.mcgill.ca/humangenetic...
Reposted by Satoshi Yoshiji, MD, PhD
Excited to share this position for a computational biologist to work on Translational Diabetes Genomics in Diverse populations. Great opportunities to learn and grow and expand your career ! Please share!
broadinstitute.avature.net/en_US/career...
broadinstitute.avature.net/en_US/career...
Computational Associate II- Translational Diabetes Genomics In Diverse Populations
Job DescriptionApply your computational and mathematical skills to solving the hardest problems in big-data genomics and have a wide impact on science and clinical practice, including diabetes and...
broadinstitute.avature.net
March 10, 2025 at 2:02 AM
Excited to share this position for a computational biologist to work on Translational Diabetes Genomics in Diverse populations. Great opportunities to learn and grow and expand your career ! Please share!
broadinstitute.avature.net/en_US/career...
broadinstitute.avature.net/en_US/career...
Honored to receive the Canadian Institutes of Health Research @CIHR_IRSC Catalyst Grant! We appreciate this valuable support for our research.
March 7, 2025 at 1:54 PM
Honored to receive the Canadian Institutes of Health Research @CIHR_IRSC Catalyst Grant! We appreciate this valuable support for our research.
Exciting news! Masashi Hasebe, a PhD student in our lab, has been awarded a JASSO doctoral scholarship ($45K CAD/year for 3 years). Congrats, Masashi! 🎉
ラボの大学院生 長谷部さんがJASSO 2025年度海外留学支援奨学金に特別枠で採択されました!
月額38.8万円を3年間支援いただける素晴らしい奨学金です。おめでとうございます!
yoshiji-lab.org/team/
www.jasso.go.jp/about/press/...
ラボの大学院生 長谷部さんがJASSO 2025年度海外留学支援奨学金に特別枠で採択されました!
月額38.8万円を3年間支援いただける素晴らしい奨学金です。おめでとうございます!
yoshiji-lab.org/team/
www.jasso.go.jp/about/press/...
Using human genetics and multi-omics to identify drug targets and improve clinical care
yoshiji-lab.org
March 6, 2025 at 10:05 PM
Exciting news! Masashi Hasebe, a PhD student in our lab, has been awarded a JASSO doctoral scholarship ($45K CAD/year for 3 years). Congrats, Masashi! 🎉
ラボの大学院生 長谷部さんがJASSO 2025年度海外留学支援奨学金に特別枠で採択されました!
月額38.8万円を3年間支援いただける素晴らしい奨学金です。おめでとうございます!
yoshiji-lab.org/team/
www.jasso.go.jp/about/press/...
ラボの大学院生 長谷部さんがJASSO 2025年度海外留学支援奨学金に特別枠で採択されました!
月額38.8万円を3年間支援いただける素晴らしい奨学金です。おめでとうございます!
yoshiji-lab.org/team/
www.jasso.go.jp/about/press/...
Reposted by Satoshi Yoshiji, MD, PhD
Faculty position opening in bioinformatics at the University of Montreal! There is a great bioinfo and comp bio community in Montreal.
www.umontreal.ca/carrieres/pr...
www.umontreal.ca/carrieres/pr...
Professeurs
www.umontreal.ca
February 28, 2025 at 4:44 PM
Faculty position opening in bioinformatics at the University of Montreal! There is a great bioinfo and comp bio community in Montreal.
www.umontreal.ca/carrieres/pr...
www.umontreal.ca/carrieres/pr...
Happy to be back at the Broad! Excited to reconnect with amazing colleagues and speak at the Diabetes Genetics Research Group😊
February 25, 2025 at 1:22 PM
Happy to be back at the Broad! Excited to reconnect with amazing colleagues and speak at the Diabetes Genetics Research Group😊
If you’re in Philly attending US HUPO, join us for the morning session tomorrow at 7:15 AM on "Leveraging Publicly Available Large-Scale Proteo-Genomics Data to Identify Proteomic Drivers of Human Diseases: A Catalog of Proteome–Phenome-Wide Associations"
somalogic.com/us-hupo-2025/
somalogic.com/us-hupo-2025/
February 23, 2025 at 10:24 PM
If you’re in Philly attending US HUPO, join us for the morning session tomorrow at 7:15 AM on "Leveraging Publicly Available Large-Scale Proteo-Genomics Data to Identify Proteomic Drivers of Human Diseases: A Catalog of Proteome–Phenome-Wide Associations"
somalogic.com/us-hupo-2025/
somalogic.com/us-hupo-2025/
Interested in using proteomics to understand disease biology?
Join us at US HUPO 2025 in Philly for the Feb 24 SomaLogic breakfast session
I'll discuss our recent study in Nature Genetics on a protein mediating obesity’s effect on CAD & our MR atlas project.
somalogic.com/us-hupo-2025...
Join us at US HUPO 2025 in Philly for the Feb 24 SomaLogic breakfast session
I'll discuss our recent study in Nature Genetics on a protein mediating obesity’s effect on CAD & our MR atlas project.
somalogic.com/us-hupo-2025...
February 19, 2025 at 7:54 PM
Interested in using proteomics to understand disease biology?
Join us at US HUPO 2025 in Philly for the Feb 24 SomaLogic breakfast session
I'll discuss our recent study in Nature Genetics on a protein mediating obesity’s effect on CAD & our MR atlas project.
somalogic.com/us-hupo-2025...
Join us at US HUPO 2025 in Philly for the Feb 24 SomaLogic breakfast session
I'll discuss our recent study in Nature Genetics on a protein mediating obesity’s effect on CAD & our MR atlas project.
somalogic.com/us-hupo-2025...
Reposted by Satoshi Yoshiji, MD, PhD
The McGill Department of Human Genetics is now on Bluesky!
@mcgill-hg.bsky.social
@mcgill-hg.bsky.social
February 10, 2025 at 7:39 PM
The McGill Department of Human Genetics is now on Bluesky!
@mcgill-hg.bsky.social
@mcgill-hg.bsky.social
Reposted by Satoshi Yoshiji, MD, PhD
McGill Human Genetics is now on Bluesky! Follow us for updates on our department’s research, events, and achievements. Stay tuned for exciting discoveries!
February 10, 2025 at 11:33 PM
McGill Human Genetics is now on Bluesky! Follow us for updates on our department’s research, events, and achievements. Stay tuned for exciting discoveries!
Reposted by Satoshi Yoshiji, MD, PhD
I see lots of patients with obesity who develop heart attacks. Often they have normal cholesterol, blood pressure and glucose levels are normal.
So why do they get heart attacks?
We identified endotrophin as a mechanism whereby obesity causes heart disease. 🧵
www.nature.com/articles/s41...
So why do they get heart attacks?
We identified endotrophin as a mechanism whereby obesity causes heart disease. 🧵
www.nature.com/articles/s41...
Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease - Nature Genetics
Two-step Mendelian randomization, combined with multiple layers of omics evidence, implicates COL6A3-derived endotrophin as a mediator of coronary artery disease risk in the context of obesity.
www.nature.com
January 26, 2025 at 9:08 PM
I see lots of patients with obesity who develop heart attacks. Often they have normal cholesterol, blood pressure and glucose levels are normal.
So why do they get heart attacks?
We identified endotrophin as a mechanism whereby obesity causes heart disease. 🧵
www.nature.com/articles/s41...
So why do they get heart attacks?
We identified endotrophin as a mechanism whereby obesity causes heart disease. 🧵
www.nature.com/articles/s41...
Reposted by Satoshi Yoshiji, MD, PhD
Very exciting work from the newest recruit to the Dept Human Genetics at McGill!
January 26, 2025 at 7:43 PM
Very exciting work from the newest recruit to the Dept Human Genetics at McGill!
Reposted by Satoshi Yoshiji, MD, PhD
A great collaboration led by @satoshiyoshiji.bsky.social , an impressive Assistant Professor at McGill University!
January 26, 2025 at 9:08 PM
A great collaboration led by @satoshiyoshiji.bsky.social , an impressive Assistant Professor at McGill University!
📣 We are hiring!
Join Yoshiji Lab at McGill University Dept of Human Genetics in Montreal, Canada!
yoshiji-lab.org/joinus
✅Fully Funded Positions
• 2 MSc Students
• 1 PhD Student
• 1 Postdoc
✅Goal: Using human genetics and multi-omics for drug target discovery and precision medicine
Join Yoshiji Lab at McGill University Dept of Human Genetics in Montreal, Canada!
yoshiji-lab.org/joinus
✅Fully Funded Positions
• 2 MSc Students
• 1 PhD Student
• 1 Postdoc
✅Goal: Using human genetics and multi-omics for drug target discovery and precision medicine
January 26, 2025 at 2:00 PM
📣 We are hiring!
Join Yoshiji Lab at McGill University Dept of Human Genetics in Montreal, Canada!
yoshiji-lab.org/joinus
✅Fully Funded Positions
• 2 MSc Students
• 1 PhD Student
• 1 Postdoc
✅Goal: Using human genetics and multi-omics for drug target discovery and precision medicine
Join Yoshiji Lab at McGill University Dept of Human Genetics in Montreal, Canada!
yoshiji-lab.org/joinus
✅Fully Funded Positions
• 2 MSc Students
• 1 PhD Student
• 1 Postdoc
✅Goal: Using human genetics and multi-omics for drug target discovery and precision medicine
my cat reviewing my paper
January 24, 2025 at 2:59 PM
my cat reviewing my paper
Reposted by Satoshi Yoshiji, MD, PhD
We’re hiring soon!
1–2 MSc positions, one PhD position (all fully funded), and a post-doc position will be available. Stay tuned and join us at McGill in the vibrant city of Montreal, Canada!
Lab webpage: yoshiji-lab.org
1–2 MSc positions, one PhD position (all fully funded), and a post-doc position will be available. Stay tuned and join us at McGill in the vibrant city of Montreal, Canada!
Lab webpage: yoshiji-lab.org
January 24, 2025 at 1:41 PM
We’re hiring soon!
1–2 MSc positions, one PhD position (all fully funded), and a post-doc position will be available. Stay tuned and join us at McGill in the vibrant city of Montreal, Canada!
Lab webpage: yoshiji-lab.org
1–2 MSc positions, one PhD position (all fully funded), and a post-doc position will be available. Stay tuned and join us at McGill in the vibrant city of Montreal, Canada!
Lab webpage: yoshiji-lab.org
📣Excited to share our paper in Nature Genetics!
rdcu.be/d7mo0
Do plasma proteins mediate obesity’s effect on CAD risk?
→Using two-step proteome-wide MR, domain-aware MR, epigenomics & scRNA-seq, we prioritized endotrophin, cleaved from COL6A3, as a mediator & potential therapeutic target.
A 🧵↓
rdcu.be/d7mo0
Do plasma proteins mediate obesity’s effect on CAD risk?
→Using two-step proteome-wide MR, domain-aware MR, epigenomics & scRNA-seq, we prioritized endotrophin, cleaved from COL6A3, as a mediator & potential therapeutic target.
A 🧵↓
January 24, 2025 at 1:41 PM
📣Excited to share our paper in Nature Genetics!
rdcu.be/d7mo0
Do plasma proteins mediate obesity’s effect on CAD risk?
→Using two-step proteome-wide MR, domain-aware MR, epigenomics & scRNA-seq, we prioritized endotrophin, cleaved from COL6A3, as a mediator & potential therapeutic target.
A 🧵↓
rdcu.be/d7mo0
Do plasma proteins mediate obesity’s effect on CAD risk?
→Using two-step proteome-wide MR, domain-aware MR, epigenomics & scRNA-seq, we prioritized endotrophin, cleaved from COL6A3, as a mediator & potential therapeutic target.
A 🧵↓
Excited to fly to South Korea to give a talk on using proteomics and genomics to understand complex traits and identify drug targets!
Very grateful to the Korean Society of Medical Genetics and Genomics for the invitation.
Join us at KSMGG&EAUHGS2024 on Dec 6 at Symposium 4.
Very grateful to the Korean Society of Medical Genetics and Genomics for the invitation.
Join us at KSMGG&EAUHGS2024 on Dec 6 at Symposium 4.
December 3, 2024 at 5:32 PM
Excited to fly to South Korea to give a talk on using proteomics and genomics to understand complex traits and identify drug targets!
Very grateful to the Korean Society of Medical Genetics and Genomics for the invitation.
Join us at KSMGG&EAUHGS2024 on Dec 6 at Symposium 4.
Very grateful to the Korean Society of Medical Genetics and Genomics for the invitation.
Join us at KSMGG&EAUHGS2024 on Dec 6 at Symposium 4.
Reposted by Satoshi Yoshiji, MD, PhD
We're looking forward to hearing @satoshiyoshiji.bsky.social speak @broadinstitute.org MPG this morning as part of Jason Flannick's overall lab seminar
November 21, 2024 at 2:13 PM
We're looking forward to hearing @satoshiyoshiji.bsky.social speak @broadinstitute.org MPG this morning as part of Jason Flannick's overall lab seminar
I’ll be speaking (virtually) at the Medical and Population Genetics Seminar @broadinstitute.org tomorrow at 9:30 AM with Dr. Jason Flannick and colleagues. If you’re at the Broad, please join us!
November 20, 2024 at 11:17 PM
I’ll be speaking (virtually) at the Medical and Population Genetics Seminar @broadinstitute.org tomorrow at 9:30 AM with Dr. Jason Flannick and colleagues. If you’re at the Broad, please join us!
Reposted by Satoshi Yoshiji, MD, PhD
🚨NEW PREPRINT!
Interested in Mendelian randomization and proteomics? 🧬
We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries!
Preprint: www.medrxiv.org/content/10.1...
Website: broad.io/protein_mr_a...
Interested in Mendelian randomization and proteomics? 🧬
We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries!
Preprint: www.medrxiv.org/content/10.1...
Website: broad.io/protein_mr_a...
November 18, 2024 at 8:19 PM
🚨NEW PREPRINT!
Interested in Mendelian randomization and proteomics? 🧬
We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries!
Preprint: www.medrxiv.org/content/10.1...
Website: broad.io/protein_mr_a...
Interested in Mendelian randomization and proteomics? 🧬
We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries!
Preprint: www.medrxiv.org/content/10.1...
Website: broad.io/protein_mr_a...
Just started on bsky!
My lab at McGill uses genomics and proteomics to understand human diseases. Check out our preprint!
📣Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targets:
www.medrxiv.org/content/10.1...
My lab at McGill uses genomics and proteomics to understand human diseases. Check out our preprint!
📣Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targets:
www.medrxiv.org/content/10.1...
November 18, 2024 at 7:15 PM
Just started on bsky!
My lab at McGill uses genomics and proteomics to understand human diseases. Check out our preprint!
📣Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targets:
www.medrxiv.org/content/10.1...
My lab at McGill uses genomics and proteomics to understand human diseases. Check out our preprint!
📣Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targets:
www.medrxiv.org/content/10.1...