Sara França
@sarassfranca.bsky.social
Biomedical Scientist interested in #Cancer #Metastasis Research | PhD applicant | Looking for Research Assistant positions in the US
https://www.linkedin.com/in/sara-susan-silva-de-fran%C3%A7a-140204204?trk=contact-info
https://www.linkedin.com/in/sara-susan-silva-de-fran%C3%A7a-140204204?trk=contact-info
7/7
Register here — it's free:
www.bihealth.org/en/translati...
Tag someone who should know about this!
And if you're already working in this space, please send me a DM, I’d love to connect 🤝🏼
Let’s make evidence stronger together.
#SysRev #MetaScience #AI #systematicreviews #research #science
Register here — it's free:
www.bihealth.org/en/translati...
Tag someone who should know about this!
And if you're already working in this space, please send me a DM, I’d love to connect 🤝🏼
Let’s make evidence stronger together.
#SysRev #MetaScience #AI #systematicreviews #research #science
May 22, 2025 at 3:30 PM
7/7
Register here — it's free:
www.bihealth.org/en/translati...
Tag someone who should know about this!
And if you're already working in this space, please send me a DM, I’d love to connect 🤝🏼
Let’s make evidence stronger together.
#SysRev #MetaScience #AI #systematicreviews #research #science
Register here — it's free:
www.bihealth.org/en/translati...
Tag someone who should know about this!
And if you're already working in this space, please send me a DM, I’d love to connect 🤝🏼
Let’s make evidence stronger together.
#SysRev #MetaScience #AI #systematicreviews #research #science
6/7
Want to be part of a generation that values both discovery and reflection?
This is a good place to start.
Let’s bring preclinical research into ✨the era of synthesis✨
#OpenScience #TranslationalResearch
Want to be part of a generation that values both discovery and reflection?
This is a good place to start.
Let’s bring preclinical research into ✨the era of synthesis✨
#OpenScience #TranslationalResearch
May 22, 2025 at 3:30 PM
6/7
Want to be part of a generation that values both discovery and reflection?
This is a good place to start.
Let’s bring preclinical research into ✨the era of synthesis✨
#OpenScience #TranslationalResearch
Want to be part of a generation that values both discovery and reflection?
This is a good place to start.
Let’s bring preclinical research into ✨the era of synthesis✨
#OpenScience #TranslationalResearch
5/7
Whether you're working on #cancer, #neuroscience, #immunology, or beyond, this approach is a powerful way to:
👉🏼 Reduce waste
👉🏼 Improve rigor
👉🏼 Strengthen the science we build on
And yes, it definitely applies to your 🐁 studies.
#RigorousScience #AnimalStudies
Whether you're working on #cancer, #neuroscience, #immunology, or beyond, this approach is a powerful way to:
👉🏼 Reduce waste
👉🏼 Improve rigor
👉🏼 Strengthen the science we build on
And yes, it definitely applies to your 🐁 studies.
#RigorousScience #AnimalStudies
May 22, 2025 at 3:30 PM
5/7
Whether you're working on #cancer, #neuroscience, #immunology, or beyond, this approach is a powerful way to:
👉🏼 Reduce waste
👉🏼 Improve rigor
👉🏼 Strengthen the science we build on
And yes, it definitely applies to your 🐁 studies.
#RigorousScience #AnimalStudies
Whether you're working on #cancer, #neuroscience, #immunology, or beyond, this approach is a powerful way to:
👉🏼 Reduce waste
👉🏼 Improve rigor
👉🏼 Strengthen the science we build on
And yes, it definitely applies to your 🐁 studies.
#RigorousScience #AnimalStudies
4/7
And guess what?
You don’t need to be a meta-analyst to start learning.
There’s an amazing free workshop coming up hosted by the Berlin Institute of Health & CAMARADES Berlin:
🗓️ May 26–28
⏰ 1–5pm CET (online)
I’ll be attending, and you can too!
#TrainingOpportunity #academia
And guess what?
You don’t need to be a meta-analyst to start learning.
There’s an amazing free workshop coming up hosted by the Berlin Institute of Health & CAMARADES Berlin:
🗓️ May 26–28
⏰ 1–5pm CET (online)
I’ll be attending, and you can too!
#TrainingOpportunity #academia
May 22, 2025 at 3:30 PM
4/7
And guess what?
You don’t need to be a meta-analyst to start learning.
There’s an amazing free workshop coming up hosted by the Berlin Institute of Health & CAMARADES Berlin:
🗓️ May 26–28
⏰ 1–5pm CET (online)
I’ll be attending, and you can too!
#TrainingOpportunity #academia
And guess what?
You don’t need to be a meta-analyst to start learning.
There’s an amazing free workshop coming up hosted by the Berlin Institute of Health & CAMARADES Berlin:
🗓️ May 26–28
⏰ 1–5pm CET (online)
I’ll be attending, and you can too!
#TrainingOpportunity #academia
3/7
Systematic reviews in preclinical research can:
✅ Reveal trends & contradictions
✅ Identify publication bias
✅ Quantify effect sizes
✅ Evaluate study quality
✅ Guide future experiments
They help us see the forest and the trees.
#EvidenceSynthesis #SysRev
Systematic reviews in preclinical research can:
✅ Reveal trends & contradictions
✅ Identify publication bias
✅ Quantify effect sizes
✅ Evaluate study quality
✅ Guide future experiments
They help us see the forest and the trees.
#EvidenceSynthesis #SysRev
May 22, 2025 at 3:30 PM
3/7
Systematic reviews in preclinical research can:
✅ Reveal trends & contradictions
✅ Identify publication bias
✅ Quantify effect sizes
✅ Evaluate study quality
✅ Guide future experiments
They help us see the forest and the trees.
#EvidenceSynthesis #SysRev
Systematic reviews in preclinical research can:
✅ Reveal trends & contradictions
✅ Identify publication bias
✅ Quantify effect sizes
✅ Evaluate study quality
✅ Guide future experiments
They help us see the forest and the trees.
#EvidenceSynthesis #SysRev
2/7
We often hear that translation fails from bench to bedside.
But the problem isn’t always the biology, it’s the evidence base.
Bias, poor reporting, underpowered studies...
#SystematicReviews help us clean up that foundation before we build on it.
doi.org/10.1186/s412...
We often hear that translation fails from bench to bedside.
But the problem isn’t always the biology, it’s the evidence base.
Bias, poor reporting, underpowered studies...
#SystematicReviews help us clean up that foundation before we build on it.
doi.org/10.1186/s412...
Lost in translation: the valley of death across preclinical and clinical divide – identification of problems and overcoming obstacles - Translational Medicine Communications
A rift that has opened up between basic research (bench) and clinical research and patients (bed) who need their new treatments, diagnostics and prevention, and this rift is widening and getting deepe...
doi.org
May 22, 2025 at 3:30 PM
2/7
We often hear that translation fails from bench to bedside.
But the problem isn’t always the biology, it’s the evidence base.
Bias, poor reporting, underpowered studies...
#SystematicReviews help us clean up that foundation before we build on it.
doi.org/10.1186/s412...
We often hear that translation fails from bench to bedside.
But the problem isn’t always the biology, it’s the evidence base.
Bias, poor reporting, underpowered studies...
#SystematicReviews help us clean up that foundation before we build on it.
doi.org/10.1186/s412...
💡 Repost & share with your peers who might find these papers useful! Also, drop any relevant paper I might have missed in the comments.
See you next week! 📝
#Cancer #NIH #Metastasis #immuno #BreastCancer #science #LCSM #melanoma #ProstateCancer #PancreaticCancer
See you next week! 📝
#Cancer #NIH #Metastasis #immuno #BreastCancer #science #LCSM #melanoma #ProstateCancer #PancreaticCancer
March 1, 2025 at 1:16 AM
💡 Repost & share with your peers who might find these papers useful! Also, drop any relevant paper I might have missed in the comments.
See you next week! 📝
#Cancer #NIH #Metastasis #immuno #BreastCancer #science #LCSM #melanoma #ProstateCancer #PancreaticCancer
See you next week! 📝
#Cancer #NIH #Metastasis #immuno #BreastCancer #science #LCSM #melanoma #ProstateCancer #PancreaticCancer
47. www.biorxiv.org/content/10.1...
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51. www.biorxiv.org/content/10.1...
Immunosuppressive myeloid cells induce mesenchymal-like breast cancer stem cells by a mechanism involving membrane-bound TGF-β1.
Suppressive myeloid cells play a central role in cancer escape from anti-tumor immunity. Beyond their immunosuppressive function, these cells are capable of exerting multiple other pro-tumoral activit...
www.biorxiv.org
March 1, 2025 at 1:16 AM
39. www.biorxiv.org/content/10.1...
40. aacrjournals.org/cancerres/ar...
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46. www.biorxiv.org/content/10.1...
Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism
The cellular programs that mediate therapy resistance are often important drivers of metastasis, a phenomenon that needs to be understood better to improve screening and treatment options for cancer p...
www.biorxiv.org
March 1, 2025 at 1:16 AM
31. www.nature.com/articles/s43...
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37. academic.oup.com/jnci/advance...
38. www.biorxiv.org/content/10.1...
Microbiome dysbiosis, neutrophil recruitment and mesenchymal transition of mesothelial cells promotes peritoneal metastasis of colorectal cancer - Nature Cancer
Li et al. show through single-cell and functional data that tumor microenvironment remodeling promotes peritoneal metastasis of colorectal cancer through microbiome dysbiosis, neutrophil recruitment a...
www.nature.com
March 1, 2025 at 1:16 AM
23. www.nature.com/articles/s41...
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Invasion and metastasis in cancer: molecular insights and therapeutic targets - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Invasion and metastasis in cancer: molecular insights and therapeutic targets
www.nature.com
March 1, 2025 at 1:16 AM
16. molecular-cancer.biomedcentral.com/articles/10....
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DCLK1-mediated regulation of invadopodia dynamics and matrix metalloproteinase trafficking drives invasive progression in head and neck squamous cell carcinoma - Molecular Cancer
Background HNSCC presents a significant health challenge due to its high mortality resulting from treatment resistance and locoregional invasion into critical structures in the head and neck region. U...
molecular-cancer.biomedcentral.com
March 1, 2025 at 1:16 AM
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SMARCA4 Inhibits Breast Cancer Progression and Metastasis through RHOA Suppression
Abstract. Triple-negative breast cancer (TNBC) presents the most challenging subtype of the disease due to its aggressive nature and lack of targeted therapy options. To identify regulators of TNBC, w...
aacrjournals.org
March 1, 2025 at 1:16 AM
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ATAD2 Drives Prostate Cancer Progression to Metastasis
Abstract. Metastasis accounts for the overwhelming majority of cancer deaths. In prostate cancer and many other solid tumors, progression to metastasis is associated with drastically reduced survival ...
aacrjournals.org
March 1, 2025 at 1:16 AM
8/ This study adds another piece to the metastatic #dormancy puzzle. Understanding how dormant cells wake up gives us new tools to fight #cancer. Read the full paper here:
www.nature.com/articles/s41...
What do you think of these findings? Let’s discuss! 🔬
#metastasis #Oncology #Immunology
www.nature.com/articles/s41...
What do you think of these findings? Let’s discuss! 🔬
#metastasis #Oncology #Immunology
Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche - Nature Communications
Metastasis-initiating cells can reawaken from a dormant state that initially allowed them to survive, triggering metastatic outgrowth. Here, authors show that loss of Brd7 promotes an immunosuppressiv...
www.nature.com
February 26, 2025 at 8:41 PM
8/ This study adds another piece to the metastatic #dormancy puzzle. Understanding how dormant cells wake up gives us new tools to fight #cancer. Read the full paper here:
www.nature.com/articles/s41...
What do you think of these findings? Let’s discuss! 🔬
#metastasis #Oncology #Immunology
www.nature.com/articles/s41...
What do you think of these findings? Let’s discuss! 🔬
#metastasis #Oncology #Immunology
7/ These findings highlight new strategies to combat metastatic recurrence, targeting both epigenetic regulation and immune interactions. Restoring Brd7 expression or modulating the immune response could be the future of metastasis treatment.
February 26, 2025 at 8:41 PM
7/ These findings highlight new strategies to combat metastatic recurrence, targeting both epigenetic regulation and immune interactions. Restoring Brd7 expression or modulating the immune response could be the future of metastasis treatment.
6/ The good news? This process can be reversed! Inhibiting NET formation with sivelestat or depleting neutrophils significantly reduced metastatic growth. Blocking CTLA-4 (an immune checkpoint) also restored anti-tumor immunity.
February 26, 2025 at 8:41 PM
6/ The good news? This process can be reversed! Inhibiting NET formation with sivelestat or depleting neutrophils significantly reduced metastatic growth. Blocking CTLA-4 (an immune checkpoint) also restored anti-tumor immunity.
5/ Neutrophils aren’t just bystanders. In this scenario, they create an immunosuppressive niche by releasing neutrophil extracellular traps (NETs), which help metastatic cells survive and contribute to T cell exhaustion.
February 26, 2025 at 8:41 PM
5/ Neutrophils aren’t just bystanders. In this scenario, they create an immunosuppressive niche by releasing neutrophil extracellular traps (NETs), which help metastatic cells survive and contribute to T cell exhaustion.
4/ Without Brd7, cancer cells downregulate MHC-I, making them less visible to the immune system. At the same time, they secrete pro-metastatic cytokines, attracting inflammatory neutrophils and exhausted CD8+ T cells.
February 26, 2025 at 8:41 PM
4/ Without Brd7, cancer cells downregulate MHC-I, making them less visible to the immune system. At the same time, they secrete pro-metastatic cytokines, attracting inflammatory neutrophils and exhausted CD8+ T cells.
3/ In breast cancer metastasis models, Brd7 loss reactivates dormant metastatic cells in the lung, leading to aggressive tumor growth. But it’s not just about the tumor cells—the immune microenvironment also shifts dramatically.
February 26, 2025 at 8:41 PM
3/ In breast cancer metastasis models, Brd7 loss reactivates dormant metastatic cells in the lung, leading to aggressive tumor growth. But it’s not just about the tumor cells—the immune microenvironment also shifts dramatically.
2/ The study focuses on Brd7, a subunit of the PBAF chromatin remodeling complex. This complex regulates DNA accessibility, influencing how cancer cells behave in new tissues. But what happens when Brd7 is lost?
February 26, 2025 at 8:41 PM
2/ The study focuses on Brd7, a subunit of the PBAF chromatin remodeling complex. This complex regulates DNA accessibility, influencing how cancer cells behave in new tissues. But what happens when Brd7 is lost?