Sara J. Weaver
@sarajweaver.bsky.social
Structural biologist in drug discovery. #CryoEM specialist. #MicroED. X-ray #crystallography. #teamtomo Industry.
Reposted by Sara J. Weaver
Our work is the first study to provide structures of several tRNAs before and after the introduction of modifications at specific sites. In detail, we analyzed 4 human tRNA species to decipher structural and stability effects induced by the installation of Ψ at single or multiple sites.
April 30, 2025 at 4:12 AM
Our work is the first study to provide structures of several tRNAs before and after the introduction of modifications at specific sites. In detail, we analyzed 4 human tRNA species to decipher structural and stability effects induced by the installation of Ψ at single or multiple sites.
Reposted by Sara J. Weaver
We used single particle cryo-EM to directly visualize several human tRNAs and analyze the effects of individual tRNA modifications. To our knowledge, the work presents interpretable maps of the smallest asymmetric particles analyzed by single-particle cryo-EM so far.
April 30, 2025 at 4:12 AM
We used single particle cryo-EM to directly visualize several human tRNAs and analyze the effects of individual tRNA modifications. To our knowledge, the work presents interpretable maps of the smallest asymmetric particles analyzed by single-particle cryo-EM so far.
Reposted by Sara J. Weaver
- identifies crucial contacts; very useful for selecting mutagenesis targets
- fixes model geometry. In cryo-EM, stereochemistry is usually the best priors you have!
- helps predicting models of weak complexes that AlphaFold3 cannot
- fixes model geometry. In cryo-EM, stereochemistry is usually the best priors you have!
- helps predicting models of weak complexes that AlphaFold3 cannot
February 6, 2025 at 10:07 AM
- identifies crucial contacts; very useful for selecting mutagenesis targets
- fixes model geometry. In cryo-EM, stereochemistry is usually the best priors you have!
- helps predicting models of weak complexes that AlphaFold3 cannot
- fixes model geometry. In cryo-EM, stereochemistry is usually the best priors you have!
- helps predicting models of weak complexes that AlphaFold3 cannot
Reposted by Sara J. Weaver
Our findings emphasize how we use PDB models. It is critical to understand that PDB models are just that, models. They do not fully explain the underlying experimental data, have nuances in how they are representing the data, and as we show, can vary in how well the underlying data is explained.
December 16, 2024 at 3:14 PM
Our findings emphasize how we use PDB models. It is critical to understand that PDB models are just that, models. They do not fully explain the underlying experimental data, have nuances in how they are representing the data, and as we show, can vary in how well the underlying data is explained.