Greg Chojnowski
@gchojnowski.bsky.social
I build EM and MX models and write software to make it a bit less of a hassle. Some of the code I wrote is a part of CCP4 and CCP-EM.
https://gchojnowski.github.io
https://gchojnowski.github.io
Reposted by Greg Chojnowski
We are excited to share our latest work, where we unravel the structural and functional secrets of the once-mysterious protein Pex8 revealing how it controls the peroxisomal cargo import receptor Pex5.
Read more here: www.biorxiv.org/content/10.1101/2025.08.30.673231v1
Read more here: www.biorxiv.org/content/10.1101/2025.08.30.673231v1
September 3, 2025 at 10:28 AM
We are excited to share our latest work, where we unravel the structural and functional secrets of the once-mysterious protein Pex8 revealing how it controls the peroxisomal cargo import receptor Pex5.
Read more here: www.biorxiv.org/content/10.1101/2025.08.30.673231v1
Read more here: www.biorxiv.org/content/10.1101/2025.08.30.673231v1
Reposted by Greg Chojnowski
Today marks the 82nd anniversary of the Warsaw Ghetto Uprising, recognized as the largest act of armed resistance undertaken by Jews during WWII. Launched against insurmountable odds, the rebellion is often cited as one of the defining moments in modern Jewish history.
82 years since the Warsaw Ghetto Uprising
The doomed Uprising led to the complete annihilation of Jewish Warsaw.
tvpworld.com
April 19, 2025 at 7:05 AM
Today marks the 82nd anniversary of the Warsaw Ghetto Uprising, recognized as the largest act of armed resistance undertaken by Jews during WWII. Launched against insurmountable odds, the rebellion is often cited as one of the defining moments in modern Jewish history.
www.goodreads.com/quotes/99381...
a grim reflection on the past and a projection of the future that has just arrived.
a grim reflection on the past and a projection of the future that has just arrived.
A quote from A People’s History of the United States
The problem of democracy in the post-Revolutionary society was not, however, the Constitutional limitations on voting. It lay deeper, beyond the Constitu...
www.goodreads.com
February 15, 2025 at 11:06 AM
www.goodreads.com/quotes/99381...
a grim reflection on the past and a projection of the future that has just arrived.
a grim reflection on the past and a projection of the future that has just arrived.
Finally!
HOLE-y!
An implementation of Oliver Smart's HOLE now available in Coot 1
Linear Gramicidin D - 2y5m - behold the lipid phase!
Coot 1.1.12 out soon
#coot
An implementation of Oliver Smart's HOLE now available in Coot 1
Linear Gramicidin D - 2y5m - behold the lipid phase!
Coot 1.1.12 out soon
#coot
February 8, 2025 at 11:05 AM
Finally!
High time to understand what's going on in there. Sadly, the historian's perspective is as depressing as that of Faulkner, Steinbeck or Bukowski.
February 8, 2025 at 8:59 AM
High time to understand what's going on in there. Sadly, the historian's perspective is as depressing as that of Faulkner, Steinbeck or Bukowski.
I’m happy to share gapTrick, an AlphaFold2-based tool for characterising protein-protein complexes
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
gapTrick - Structural characterisation of protein-protein interactions using AlphaFold with multimeric templates
The structural characterisation of protein-protein interactions is a key step in understanding the functions of living cells. Models of protein complexes provide important insights into interaction me...
www.biorxiv.org
February 6, 2025 at 10:07 AM
I’m happy to share gapTrick, an AlphaFold2-based tool for characterising protein-protein complexes
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The book doesn't really explain why we sleep, but the message is very simple and convincing: "Go the f*k to sleep!". Highly recommended (the book too).
February 1, 2025 at 8:40 PM
The book doesn't really explain why we sleep, but the message is very simple and convincing: "Go the f*k to sleep!". Highly recommended (the book too).
Reposted by Greg Chojnowski
This might be a good opportunity to remind people that experimental data (diffraction or cryoEM maps) have to be provided with the submission of papers to the IUCr society journals on Structural Biology, Acta Cryst D and F. So referees don’t even have to ask any more!
Peer review pet peeve: I ask for maps & coordinates for review, editor says “yes, of course, we will get these to you”. And then nothing happens until the “your review is (over)due” reminders pour in. You want me to do a proper job or just submit whatever other ramblings I might have come up with?
January 18, 2025 at 12:41 PM
This might be a good opportunity to remind people that experimental data (diffraction or cryoEM maps) have to be provided with the submission of papers to the IUCr society journals on Structural Biology, Acta Cryst D and F. So referees don’t even have to ask any more!
Reposted by Greg Chojnowski
We have released version 2 of AlphaPulldown - a general pipeline for high-throughput structural modeling!
Software: github.com/KosinskiLab/...
Preprint: biorxiv.org/content/10.1...
Software: github.com/KosinskiLab/...
Preprint: biorxiv.org/content/10.1...
December 4, 2024 at 10:02 AM
We have released version 2 of AlphaPulldown - a general pipeline for high-throughput structural modeling!
Software: github.com/KosinskiLab/...
Preprint: biorxiv.org/content/10.1...
Software: github.com/KosinskiLab/...
Preprint: biorxiv.org/content/10.1...
Reposted by Greg Chojnowski
EMBL is Europe’s life sciences laboratory. 🧬🧪
At our sites in Barcelona, Grenoble, Hamburg, Heidelberg, Hinxton, and Rome, we seek to understand life in context, from molecules to ecosystems. 🔬🌍
Follow us for our latest news and updates about research, training, services and more. www.embl.org
At our sites in Barcelona, Grenoble, Hamburg, Heidelberg, Hinxton, and Rome, we seek to understand life in context, from molecules to ecosystems. 🔬🌍
Follow us for our latest news and updates about research, training, services and more. www.embl.org
European Molecular Biology Laboratory
With 29 member states, laboratories at six locations across Europe and thousands of scientists and engineers working together, the European Molecular Biology Laboratory is a powerhouse of biological e...
www.embl.org
November 21, 2024 at 2:07 PM
EMBL is Europe’s life sciences laboratory. 🧬🧪
At our sites in Barcelona, Grenoble, Hamburg, Heidelberg, Hinxton, and Rome, we seek to understand life in context, from molecules to ecosystems. 🔬🌍
Follow us for our latest news and updates about research, training, services and more. www.embl.org
At our sites in Barcelona, Grenoble, Hamburg, Heidelberg, Hinxton, and Rome, we seek to understand life in context, from molecules to ecosystems. 🔬🌍
Follow us for our latest news and updates about research, training, services and more. www.embl.org
Reposted by Greg Chojnowski
Really looking forward to welcoming & meeting the participants of our #EMBOStructBio course this morning!
Many of our speakers/tutors are here:
@moalquraishi.bsky.social
@sykhalid.bsky.social
@ezgikaraca.bsky.social
@amjjbonvin.bsky.social
@gchojnowski.bsky.social
@drmelissagraewert.bsky.social
Many of our speakers/tutors are here:
@moalquraishi.bsky.social
@sykhalid.bsky.social
@ezgikaraca.bsky.social
@amjjbonvin.bsky.social
@gchojnowski.bsky.social
@drmelissagraewert.bsky.social
November 18, 2024 at 7:07 AM
Really looking forward to welcoming & meeting the participants of our #EMBOStructBio course this morning!
Many of our speakers/tutors are here:
@moalquraishi.bsky.social
@sykhalid.bsky.social
@ezgikaraca.bsky.social
@amjjbonvin.bsky.social
@gchojnowski.bsky.social
@drmelissagraewert.bsky.social
Many of our speakers/tutors are here:
@moalquraishi.bsky.social
@sykhalid.bsky.social
@ezgikaraca.bsky.social
@amjjbonvin.bsky.social
@gchojnowski.bsky.social
@drmelissagraewert.bsky.social
Reposted by Greg Chojnowski
New GPU-based MMseqs2: 20x faster searches on a single L40S (approx. as fast as a RTX 4090) vs. a 128-core CPU. This work enables to set up a very cost-efficient ColabFold MSA GPU server. 🧵🧵
📄 www.biorxiv.org/content/10.1...
💾 mmseqs.com
🗞️ developer.nvidia.com/blog/boost-a...
📄 www.biorxiv.org/content/10.1...
💾 mmseqs.com
🗞️ developer.nvidia.com/blog/boost-a...
November 15, 2024 at 11:02 PM
New GPU-based MMseqs2: 20x faster searches on a single L40S (approx. as fast as a RTX 4090) vs. a 128-core CPU. This work enables to set up a very cost-efficient ColabFold MSA GPU server. 🧵🧵
📄 www.biorxiv.org/content/10.1...
💾 mmseqs.com
🗞️ developer.nvidia.com/blog/boost-a...
📄 www.biorxiv.org/content/10.1...
💾 mmseqs.com
🗞️ developer.nvidia.com/blog/boost-a...
Reposted by Greg Chojnowski
How many of the PDB models that were solved using experimental phasing could have been solved by molecular replacement using models obtained from AlphaFold? #MolecularReplacement #AlphaFold2 #ComputationalMethods t.co/s6EahtcYms
November 14, 2024 at 2:41 PM
How many of the PDB models that were solved using experimental phasing could have been solved by molecular replacement using models obtained from AlphaFold? #MolecularReplacement #AlphaFold2 #ComputationalMethods t.co/s6EahtcYms