Sam Connell
@samuelconnell.bsky.social
Scientist and Global Sales Director at 3i (@the.3i.social), foodie, family man. Tai Chi and meditation matter. Compassion Heals. Microscopes Rock. https://www.intelligent-imaging.com
Reposted by Sam Connell
The new glutamate indicators were announced today in
@natmethods.nature.com.
🔗 www.nature.com/articles/s41...
@natmethods.nature.com.
🔗 www.nature.com/articles/s41...
Glutamate indicators with increased sensitivity and tailored deactivation rates - Nature Methods
iGluSnFR4f and iGluSnFR4s are the latest generation of genetically encoded glutamate sensors. They are advantageous for detecting rapid dynamics and large population activity, respectively, as demonst...
www.nature.com
December 23, 2025 at 6:01 PM
The new glutamate indicators were announced today in
@natmethods.nature.com.
🔗 www.nature.com/articles/s41...
@natmethods.nature.com.
🔗 www.nature.com/articles/s41...
I think @michael-syglass.bsky.social would absolutely try to talk you into it. Not sure if you have played with 3D Light Sheet data with Syglass yet, but it's a particularly unique experience and an enabling technology in unexpected ways. Let us know if you'd like to explore more...
December 22, 2025 at 8:34 PM
I think @michael-syglass.bsky.social would absolutely try to talk you into it. Not sure if you have played with 3D Light Sheet data with Syglass yet, but it's a particularly unique experience and an enabling technology in unexpected ways. Let us know if you'd like to explore more...
Reposted by Sam Connell
We have a number of fluorescent protein pairs here that are great for FLIM www.addgene.org/browse/artic...
A conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cells - PubMed
Conformational changes in endocytic proteins are regulators of clathrin-mediated endocytosis. Three clathrin heavy chains associated with clathrin light chains (CLC) assemble into triskelia that link into a geometric lattice that curves to drive endocytosis. Structural changes in CLC have been shown …
pubmed.ncbi.nlm.nih.gov
December 22, 2025 at 2:34 PM
We have a number of fluorescent protein pairs here that are great for FLIM www.addgene.org/browse/artic...