@samirwatson.bsky.social
Reposted
🌟📢 The September 1st issue of RNA Modifications Digest is here 🧬
From frameshift-preventing tRNA mods to aa-tRNA-seq breakthroughs and hidden damage by Tgt, and check also the preprints. 🦠💫 #microsku #rnasky open.substack.com/pub/rnamodif...
From frameshift-preventing tRNA mods to aa-tRNA-seq breakthroughs and hidden damage by Tgt, and check also the preprints. 🦠💫 #microsku #rnasky open.substack.com/pub/rnamodif...
RNA modifications digest - 2025, September 1st
Bimonthly newsletter: RNA modifications and related topics, mostly in bacteria. Issue #2
open.substack.com
September 1, 2025 at 7:26 AM
🌟📢 The September 1st issue of RNA Modifications Digest is here 🧬
From frameshift-preventing tRNA mods to aa-tRNA-seq breakthroughs and hidden damage by Tgt, and check also the preprints. 🦠💫 #microsku #rnasky open.substack.com/pub/rnamodif...
From frameshift-preventing tRNA mods to aa-tRNA-seq breakthroughs and hidden damage by Tgt, and check also the preprints. 🦠💫 #microsku #rnasky open.substack.com/pub/rnamodif...
Reposted
New manuscript from the Novoa lab was published this week in Genome Biology! You can give it a read here: rdcu.be/ebiIs
February 28, 2025 at 4:18 PM
New manuscript from the Novoa lab was published this week in Genome Biology! You can give it a read here: rdcu.be/ebiIs
Reposted
🚨 New preprint alert 🚨
We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
Systematic benchmarking of basecalling models for RNA modification detection with highly multiplexed nanopore sequencing
Nanopore direct RNA sequencing (DRS) holds promise for advancing our understanding of the epitranscriptome by detecting RNA modifications in native RNA molecules. Recently, Oxford Nanopore Technologie...
bit.ly
July 14, 2025 at 4:00 PM
🚨 New preprint alert 🚨
We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
Reposted
Just casually doing some SUP basecalling on an AMD 7900XTX GPU 😅 with ROCm in a workstation at home.
A work in progress by Hasindu and Bonson in the lab.
A work in progress by Hasindu and Bonson in the lab.
May 7, 2025 at 2:51 AM
Just casually doing some SUP basecalling on an AMD 7900XTX GPU 😅 with ROCm in a workstation at home.
A work in progress by Hasindu and Bonson in the lab.
A work in progress by Hasindu and Bonson in the lab.
Reposted
Our latest paper is out in NAR! 🥳
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...
DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects
Abstract. The 22q11.2 deletion syndrome (22qDS) is a human disorder where the majority of clinical manifestations originate during embryonic development. 2
academic.oup.com
March 27, 2025 at 10:13 AM
Our latest paper is out in NAR! 🥳
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...
Reposted
Our latest paper is out in NAR! 🥳
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...
DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects
Abstract. The 22q11.2 deletion syndrome (22qDS) is a human disorder where the majority of clinical manifestations originate during embryonic development. 2
academic.oup.com
March 28, 2025 at 11:59 AM
Reposted
#RNAsky friends, how come this super cool lab has only 15 followers? They deserve more !!!!
bsky.app/profile/misk...
bsky.app/profile/misk...
a man with a mustache and a blue jacket is holding a bottle of bluesky .
ALT: a man with a mustache and a blue jacket is holding a bottle of bluesky .
media.tenor.com
March 21, 2025 at 10:45 PM
#RNAsky friends, how come this super cool lab has only 15 followers? They deserve more !!!!
bsky.app/profile/misk...
bsky.app/profile/misk...
Reposted
Wow this is super cool! Single-cell resolution imaging of #mRNA-LNP biodistribution in cleared mouse bodies.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning - Nature Biotechnology
An integrated experimental and deep learning pipeline reveals cell-level targeting of nanocarriers in whole bodies.
www.nature.com
January 20, 2025 at 8:15 PM
Wow this is super cool! Single-cell resolution imaging of #mRNA-LNP biodistribution in cleared mouse bodies.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
recruiting a PhD student interested in the role of RNA binding proteins 🧬for antiviral defence 🦠during embryonic development🐁 👶. Funding routes for both UK and international students are available 🌻. Please send your CV and motivation letter if interested
saramaciasribela.wixsite.com/maciaslab
saramaciasribela.wixsite.com/maciaslab
November 18, 2024 at 4:16 PM
recruiting a PhD student interested in the role of RNA binding proteins 🧬for antiviral defence 🦠during embryonic development🐁 👶. Funding routes for both UK and international students are available 🌻. Please send your CV and motivation letter if interested
saramaciasribela.wixsite.com/maciaslab
saramaciasribela.wixsite.com/maciaslab
Reposted
Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list!
go.bsky.app/SinqoJU
go.bsky.app/SinqoJU
November 10, 2024 at 2:43 PM
Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list!
go.bsky.app/SinqoJU
go.bsky.app/SinqoJU