Sam Barritt
@sambarritt.bsky.social
Industry scientist interested in cancer biology, radiologands, metabolism, cell signaling, et al.
HMS alum from Christian Dibble/Alex Toker labs
HMS alum from Christian Dibble/Alex Toker labs
Reposted by Sam Barritt
#GlycoPower! @vijayrathinam.bsky.social
@raflynn5.bsky.social @vinnieviruses.bsky.social &co show @nature.com that N-glycosylation of host small-RNAs present at cell surface prevents immune recognition by TLR3 and TLR7 upon apoptotic cells uptake avoiding autoinflammation!
@raflynn5.bsky.social @vinnieviruses.bsky.social &co show @nature.com that N-glycosylation of host small-RNAs present at cell surface prevents immune recognition by TLR3 and TLR7 upon apoptotic cells uptake avoiding autoinflammation!
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
www.nature.com
August 6, 2025 at 10:12 PM
#GlycoPower! @vijayrathinam.bsky.social
@raflynn5.bsky.social @vinnieviruses.bsky.social &co show @nature.com that N-glycosylation of host small-RNAs present at cell surface prevents immune recognition by TLR3 and TLR7 upon apoptotic cells uptake avoiding autoinflammation!
@raflynn5.bsky.social @vinnieviruses.bsky.social &co show @nature.com that N-glycosylation of host small-RNAs present at cell surface prevents immune recognition by TLR3 and TLR7 upon apoptotic cells uptake avoiding autoinflammation!
Reposted by Sam Barritt
AND IT'S DONE! A 🧵 on our recent article now out in @natsmb.nature.com! Co-led with @abbybartlett.bsky.social, Pagliarini Lab, @judisimcox.bsky.social, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯 doi.org/10.1038/s415...
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism - Nature Structural & Molecular Biology
Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and peroxisomal acyl-CoA dehydrogenases, respectively) ...
doi.org
June 22, 2025 at 11:30 PM
AND IT'S DONE! A 🧵 on our recent article now out in @natsmb.nature.com! Co-led with @abbybartlett.bsky.social, Pagliarini Lab, @judisimcox.bsky.social, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯 doi.org/10.1038/s415...
Reposted by Sam Barritt
Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Rhodoquinone carries electrons in the mammalian electron transport chain
Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian
mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal
electron acceptor. The authors de...
www.cell.com
February 4, 2025 at 9:40 PM
Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Sam Barritt
First post! Starting by pinning our review in Nature Metabolism on Coenzyme A biosynthesis and metabolism. Check it out if you didn't catch it when it was published!
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Coenzyme A biosynthesis: mechanisms of regulation, function and disease - Nature Metabolism
This Review summarizes the fundamental aspects related to coenzyme A synthesis and its implications as a central molecule in metabolism.
www.nature.com
January 31, 2025 at 7:45 PM
First post! Starting by pinning our review in Nature Metabolism on Coenzyme A biosynthesis and metabolism. Check it out if you didn't catch it when it was published!
www.nature.com/articles/s42...
www.nature.com/articles/s42...
This is the lab where I truly became a scientist! Awesome opportunity to make big discoveries and learn from the best in a deeply talented, supportive community.
We’re hiring a #postdoc! The Dibble Lab at Harvard Medical School and Beth Israel Deaconess Medical Center in Boston studies the regulatory relationship between #signaling and #metabolic pathways. Email me at ccdibble@bidmc.harvard.edu !
February 1, 2025 at 2:27 AM
This is the lab where I truly became a scientist! Awesome opportunity to make big discoveries and learn from the best in a deeply talented, supportive community.
Awesome to see this study from @mkleinert.bsky.social team on PANK4 function in vivo. Further evidence PANK4 suppresses acetyl-CoA (by KO AND overexpression) and that pT406 is downstream of insulin in humans! Excited to learn more about S63 and modes of regulation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications
Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...
www.nature.com
January 5, 2025 at 2:17 PM
Awesome to see this study from @mkleinert.bsky.social team on PANK4 function in vivo. Further evidence PANK4 suppresses acetyl-CoA (by KO AND overexpression) and that pT406 is downstream of insulin in humans! Excited to learn more about S63 and modes of regulation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sam Barritt
Beyond excited to share that the main work of my PhD on how aspartate signaling drives metastasis is finally out in @nature.com ✨
-> go.nature.com/4gCYtuL
A huge thank to the @fendtlab.bsky.social and all our collaborators for the terrific team work 🙏
A brief 🧵
-> go.nature.com/4gCYtuL
A huge thank to the @fendtlab.bsky.social and all our collaborators for the terrific team work 🙏
A brief 🧵
Aspartate signalling drives lung metastasis via alternative translation - Nature
Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.
go.nature.com
January 1, 2025 at 4:56 PM
Beyond excited to share that the main work of my PhD on how aspartate signaling drives metastasis is finally out in @nature.com ✨
-> go.nature.com/4gCYtuL
A huge thank to the @fendtlab.bsky.social and all our collaborators for the terrific team work 🙏
A brief 🧵
-> go.nature.com/4gCYtuL
A huge thank to the @fendtlab.bsky.social and all our collaborators for the terrific team work 🙏
A brief 🧵