Saheli Sadanand
@sahelisadanand.bsky.social
Deputy Editor at Nature Medicine | Handling & overseeing research in #Oncology #Immunology #Immunotherapy #InfectiousDiseases | Fan of vaccines, 🦖 & democracy | Views all mine
Reposted by Saheli Sadanand
Three studies that leverage blood-based gene expression data identify host response signatures in #sepsis and critical illnesses, opening a pathway to mechanism-anchored #precisiontherapy.
News & Views from Robert Stevens and Carl Harris @jhu.edu
https://www.nature.com/articles/s41591-025-04005-x
News & Views from Robert Stevens and Carl Harris @jhu.edu
https://www.nature.com/articles/s41591-025-04005-x
Unlocking host response signatures in sepsis and critical illnesses - Nature Medicine
Three studies that leverage blood-based gene expression data identify molecular and cellular host response signatures in sepsis and critical illnesses, opening a pathway to mechanism-anchored precision therapy.
www.nature.com
October 14, 2025 at 4:30 PM
Three studies that leverage blood-based gene expression data identify host response signatures in #sepsis and critical illnesses, opening a pathway to mechanism-anchored #precisiontherapy.
News & Views from Robert Stevens and Carl Harris @jhu.edu
https://www.nature.com/articles/s41591-025-04005-x
News & Views from Robert Stevens and Carl Harris @jhu.edu
https://www.nature.com/articles/s41591-025-04005-x
Reposted by Saheli Sadanand
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
nyti.ms
October 8, 2025 at 11:29 PM
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
📰 Please read this important news feature in @natmed.nature.com written by @marianneguenot.bsky.social
It is impossible to reconcile this administration's alleged commitment to "Gold Standard Science" with their harmful actions against important biomedical research
www.nature.com/articles/s41...
It is impossible to reconcile this administration's alleged commitment to "Gold Standard Science" with their harmful actions against important biomedical research
www.nature.com/articles/s41...
The damage done - Nature Medicine
When clinical trials are suddenly halted by US funding cuts, there are repercussions for investigators and patients, and they do not stop at borders.
www.nature.com
October 2, 2025 at 12:19 AM
📰 Please read this important news feature in @natmed.nature.com written by @marianneguenot.bsky.social
It is impossible to reconcile this administration's alleged commitment to "Gold Standard Science" with their harmful actions against important biomedical research
www.nature.com/articles/s41...
It is impossible to reconcile this administration's alleged commitment to "Gold Standard Science" with their harmful actions against important biomedical research
www.nature.com/articles/s41...
Reposted by Saheli Sadanand
Ever since I learned about this study enrolling I have been eagerly awaiting the results. Researchers in Uganda took a centuries-old cultural practice mothers carrying babies on their backs in cloth wraps and turned it into a public health tool. You got to love it!
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Permethrin-Treated Baby Wraps for the Prevention of Malaria | NEJM
Malaria remains a major cause of childhood death in sub-Saharan Africa. We leveraged
the traditional practice of mothers carrying children on their backs in cloth wraps
to assess whether treating t...
www.nejm.org
September 24, 2025 at 9:13 PM
Ever since I learned about this study enrolling I have been eagerly awaiting the results. Researchers in Uganda took a centuries-old cultural practice mothers carrying babies on their backs in cloth wraps and turned it into a public health tool. You got to love it!
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
SO the people actively sowing distrust in vaccines (i.e. many of the people in RFK's new ACIP) are also saying that we need to change safe and highly effective vaccine schedules because of this same lack of trust. Make it make sense!
Finally, an answer came back: we must make changes because trust in vaccines has decreased. “The signal that is prompting this is not one of safety, but one of trust,” said member Robert Malone. 3/
September 19, 2025 at 2:19 PM
SO the people actively sowing distrust in vaccines (i.e. many of the people in RFK's new ACIP) are also saying that we need to change safe and highly effective vaccine schedules because of this same lack of trust. Make it make sense!
Reposted by Saheli Sadanand
ACIP voted 7-3 to NOT recommend MMRV combo vaccine for kids <4yo. Then in a confusing second vote (1 yes, 8 no, 3 abstentions - some citing confusion), they kept VFC coverage for the same vaccine they just said not to use.
This chaos matters for every family. 1/8
This chaos matters for every family. 1/8
September 18, 2025 at 10:50 PM
ACIP voted 7-3 to NOT recommend MMRV combo vaccine for kids <4yo. Then in a confusing second vote (1 yes, 8 no, 3 abstentions - some citing confusion), they kept VFC coverage for the same vaccine they just said not to use.
This chaos matters for every family. 1/8
This chaos matters for every family. 1/8
Reposted by Saheli Sadanand
Here's the upshot on hepatitis B vaccination at birth:
- it's extremely safe
- the earlier it's given, the better it protects against transmission from mother-to-child
- screening fails to capture many cases and is not done at all in many cases
- perinatal HBV infection is catastrophic
- it's extremely safe
- the earlier it's given, the better it protects against transmission from mother-to-child
- screening fails to capture many cases and is not done at all in many cases
- perinatal HBV infection is catastrophic
September 18, 2025 at 6:40 PM
Here's the upshot on hepatitis B vaccination at birth:
- it's extremely safe
- the earlier it's given, the better it protects against transmission from mother-to-child
- screening fails to capture many cases and is not done at all in many cases
- perinatal HBV infection is catastrophic
- it's extremely safe
- the earlier it's given, the better it protects against transmission from mother-to-child
- screening fails to capture many cases and is not done at all in many cases
- perinatal HBV infection is catastrophic
A horrible horrible decision with NO rationale.
NEWS: By vaccinating babies at birth, the U.S. nearly eradicated hepatitis-B in children.
Kennedy's vaccine advisory panel is expected this week to recommend delaying the shot, opening a window for kids to be infected.
Exclusive by @jackie-fortier.bsky.social
kffhealthnews.org/news/article...
Kennedy's vaccine advisory panel is expected this week to recommend delaying the shot, opening a window for kids to be infected.
Exclusive by @jackie-fortier.bsky.social
kffhealthnews.org/news/article...
RFK Jr.’s Vaccine Panel Expected To Recommend Delaying Hepatitis B Shot for Children - KFF Health News
A federal vaccine panel, recently reshaped by Health and Human Services Secretary Robert F. Kennedy Jr., is expected to vote on delaying the hepatitis B shot for newborns. Pediatricians warn that coul...
kffhealthnews.org
September 16, 2025 at 3:16 PM
A horrible horrible decision with NO rationale.
Reposted by Saheli Sadanand
On the Trump administration's cruel disbanding of the Pediatric Brain Tumor Consortium: my op-ed @statnews.com
My 12-year-old son died from brain cancer. This research would have helped children like him
www.statnews.com/2025/09/15/p...
My 12-year-old son died from brain cancer. This research would have helped children like him
www.statnews.com/2025/09/15/p...
The Trump admin’s cruel disbanding of the Pediatric Brain Tumor Consortium
My 12-year-old son died from brain cancer. The defunding of the Pediatric Brain Tumor Consortium will deny treatments to children like him.
www.statnews.com
September 15, 2025 at 10:12 AM
On the Trump administration's cruel disbanding of the Pediatric Brain Tumor Consortium: my op-ed @statnews.com
My 12-year-old son died from brain cancer. This research would have helped children like him
www.statnews.com/2025/09/15/p...
My 12-year-old son died from brain cancer. This research would have helped children like him
www.statnews.com/2025/09/15/p...
Reposted by Saheli Sadanand
Do NOT allow them to rewrite history with disinformation. #COVID vaccines worked remarkably well and allowed us to come out of a global pandemic. A picture is worth a thousand words.
August 28, 2025 at 2:43 PM
Do NOT allow them to rewrite history with disinformation. #COVID vaccines worked remarkably well and allowed us to come out of a global pandemic. A picture is worth a thousand words.
🌟Proud to publish these exciting data in #NatureMedicine -- final results from a phase 1/2 trial + a case series show strong efficacy of GD2 CAR-T cells in children with high risk #Neuroblastoma
#immunotherapy #OncSky #PedSky @natureportfolio.nature.com
www.nature.com/articles/s41...
#immunotherapy #OncSky #PedSky @natureportfolio.nature.com
www.nature.com/articles/s41...
GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/phase 2 trial - Nature Medicine
In the final analysis of a phase 1/phase 2 trial of autologous GD2-targeting CAR T cells in pediatric patients with high-risk metastatic, relapsed or refractory neuroblastoma, treatment was overall we...
www.nature.com
August 21, 2025 at 6:18 PM
🌟Proud to publish these exciting data in #NatureMedicine -- final results from a phase 1/2 trial + a case series show strong efficacy of GD2 CAR-T cells in children with high risk #Neuroblastoma
#immunotherapy #OncSky #PedSky @natureportfolio.nature.com
www.nature.com/articles/s41...
#immunotherapy #OncSky #PedSky @natureportfolio.nature.com
www.nature.com/articles/s41...
Reposted by Saheli Sadanand
AAP's immunization recommendations are based only in the science, the needs of children, and the care that pediatricians have for the children in every community. If you have any questions about our recommended schedule, reach out to your pediatrician.
aao.org
aao.org
August 20, 2025 at 2:34 PM
AAP's immunization recommendations are based only in the science, the needs of children, and the care that pediatricians have for the children in every community. If you have any questions about our recommended schedule, reach out to your pediatrician.
aao.org
aao.org
New and important #NatureMedicine correspondence on the health consequences of forced displacement in Gaza
"These proposals are not humanitarian...Every effort must center on the health, humanity and rights of Palestinians, not their removal."
www.nature.com/articles/d41...
"These proposals are not humanitarian...Every effort must center on the health, humanity and rights of Palestinians, not their removal."
www.nature.com/articles/d41...
Health consequences of forced displacements from Gaza
Discover the world’s best science and medicine | Nature.com
www.nature.com
August 15, 2025 at 5:13 PM
New and important #NatureMedicine correspondence on the health consequences of forced displacement in Gaza
"These proposals are not humanitarian...Every effort must center on the health, humanity and rights of Palestinians, not their removal."
www.nature.com/articles/d41...
"These proposals are not humanitarian...Every effort must center on the health, humanity and rights of Palestinians, not their removal."
www.nature.com/articles/d41...
🌟NEW in #NatureMedicine: Results from a phase 2 trial suggest that anti-PD-1 #immunotherapy should be the preferred treatment choice for patients with unresectable desmoplastic #melanoma -- complete response rate of 37% and a post hoc ORR of 89% (!!) #OncSky #MedSky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase 2 SWOG S1512 trial - Nature Medicine
In cohort B of the phase 2 SWOG S1512 trial, pembrolizumab monotherapy in patients with unresectable desmoplastic melanoma elicited a complete response rate of 37% and an objective response rate of 89...
www.nature.com
August 14, 2025 at 3:30 PM
🌟NEW in #NatureMedicine: Results from a phase 2 trial suggest that anti-PD-1 #immunotherapy should be the preferred treatment choice for patients with unresectable desmoplastic #melanoma -- complete response rate of 37% and a post hoc ORR of 89% (!!) #OncSky #MedSky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Saheli Sadanand
I cannot emphasize enough that the playbook being used against mRNA vaccines (and vaccines in general) is IDENTICAL to the playbook used to restrict voting rights after the 2020 election: actively sow public distrust, then cite the distrust you sowed as an independent reason for your desired policy
Opinion | Jay Bhattacharya: Why the NIH is pivoting away from mRNA vaccines
As a vaccine for broad public use, mRNA technology has failed to earn the public’s trust.
www.washingtonpost.com
August 12, 2025 at 9:40 PM
I cannot emphasize enough that the playbook being used against mRNA vaccines (and vaccines in general) is IDENTICAL to the playbook used to restrict voting rights after the 2020 election: actively sow public distrust, then cite the distrust you sowed as an independent reason for your desired policy
⭐NEW in #NatureMedicine: final results from a phase 1 trial of an off-the-shelf, lymph node-targeted mKRAS peptide #vaccine for patients with #PancreaticCancer and #ColorectalCancer! Great efficacy results when T cell responses are strong 💪 AND signs of antigen spread!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: phase 1 AMPLIFY-201 trial final results - Nature Medicine
In the final analysis of a phase 1 trial evaluating a lymph node-targeting mutant KRAS peptide vaccine combined with CpG in the adjuvant setting for patients with KRAS mutant pancreatic or colorectal ...
www.nature.com
August 12, 2025 at 6:43 PM
⭐NEW in #NatureMedicine: final results from a phase 1 trial of an off-the-shelf, lymph node-targeted mKRAS peptide #vaccine for patients with #PancreaticCancer and #ColorectalCancer! Great efficacy results when T cell responses are strong 💪 AND signs of antigen spread!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The mainstream media has already forgotten about this, of course. It's not convenient to explore the fact that the HHS secretary and his MAHA movement are quite literally jeopardizing the safety of healthcare workers by amplifying dangerous (and incorrect!) conspiracy theories.
Rocky start for new #CDC director Susan Monarez, whose first week was punctuated by Friday's attack. Her first all-hands meeting lasted ~13 minutes, with technical challenges with dead air for a time & some staff unable to join the call. "This is a mess," one said. www.statnews.com/2025/08/12/c...
CDC leaders attempt to reassure staff after shooting, but meeting is brief
An all-hands meeting at the CDC to discuss the attack on the agency on Friday was brief and chaotic, staffers say.
www.statnews.com
August 12, 2025 at 5:10 PM
The mainstream media has already forgotten about this, of course. It's not convenient to explore the fact that the HHS secretary and his MAHA movement are quite literally jeopardizing the safety of healthcare workers by amplifying dangerous (and incorrect!) conspiracy theories.
Important to remember that Russell Vought has directly benefitted from NIH-funded research. His daughter, who has cystic fibrosis, takes Trikafta: www.motherjones.com/politics/202...
Sadly, it seems that he is perfectly OK destroying innovative research that could benefit other families.
Sadly, it seems that he is perfectly OK destroying innovative research that could benefit other families.
August 8, 2025 at 5:18 PM
Important to remember that Russell Vought has directly benefitted from NIH-funded research. His daughter, who has cystic fibrosis, takes Trikafta: www.motherjones.com/politics/202...
Sadly, it seems that he is perfectly OK destroying innovative research that could benefit other families.
Sadly, it seems that he is perfectly OK destroying innovative research that could benefit other families.
🤔I am curious about the ethics and logistics of demonstrating efficacy of an anti-measles antibody & about the strangely optimistic perspective that anti-vaccine/vaccine-hesitant parents would be willing to give their children a drug like this given their general attitudes towards modern medicine.
As the US hits a 33-year high in measles infections, there is now a "race" to find a treatment for the disease.
One pharma company "is banking on a continuing decline in vaccination rates to fuel a need for measles treatments—and in turn, more investor interest"
🎁 link
www.wsj.com/health/healt...
One pharma company "is banking on a continuing decline in vaccination rates to fuel a need for measles treatments—and in turn, more investor interest"
🎁 link
www.wsj.com/health/healt...
The Race to Find a Measles Treatment as Infections Surge
The measles vaccine was so effective the disease was considered eliminated in the U.S., but a resurgence of outbreaks is spurring a need for drugs.
www.wsj.com
August 8, 2025 at 3:31 PM
🤔I am curious about the ethics and logistics of demonstrating efficacy of an anti-measles antibody & about the strangely optimistic perspective that anti-vaccine/vaccine-hesitant parents would be willing to give their children a drug like this given their general attitudes towards modern medicine.
(1/2) "At the outset of his tenure, it seemed that Mr. Kennedy might not allow his skepticism of vaccines to influence national policy"
Huh? Lots of people warned that this would happen...
www.nytimes.com/2025/08/07/h...
Huh? Lots of people warned that this would happen...
www.nytimes.com/2025/08/07/h...
On Vaccines, Kennedy Has Broken Sharply With the Mainstream
www.nytimes.com
August 8, 2025 at 2:52 PM
(1/2) "At the outset of his tenure, it seemed that Mr. Kennedy might not allow his skepticism of vaccines to influence national policy"
Huh? Lots of people warned that this would happen...
www.nytimes.com/2025/08/07/h...
Huh? Lots of people warned that this would happen...
www.nytimes.com/2025/08/07/h...
Reposted by Saheli Sadanand
Reposted by Saheli Sadanand
The mRNA vaccine platform has already been assessed across diverse clinical indications, many with remarkable progress:
—cancer neoantigen vaccines [in patients with refractory disease (e.g. pancreatic)]
—more than 15 infectious diseases
—autoimmune diseases
—rare disease for genome editing
—cancer neoantigen vaccines [in patients with refractory disease (e.g. pancreatic)]
—more than 15 infectious diseases
—autoimmune diseases
—rare disease for genome editing
August 6, 2025 at 1:37 AM
The mRNA vaccine platform has already been assessed across diverse clinical indications, many with remarkable progress:
—cancer neoantigen vaccines [in patients with refractory disease (e.g. pancreatic)]
—more than 15 infectious diseases
—autoimmune diseases
—rare disease for genome editing
—cancer neoantigen vaccines [in patients with refractory disease (e.g. pancreatic)]
—more than 15 infectious diseases
—autoimmune diseases
—rare disease for genome editing
Horrible decision but sadly par for the course for the HHS secretary.
Pandemic preparedness in the US has been leveled a crippling blow with the cancellation of multiple #BARDA contracts to help develop mRNA vaccines. No other vaccine platform produces vaccine so quickly; without mRNA, Americans will have a long wait for pandemic vax. www.statnews.com/2025/08/05/m...
Health secretary RFK Jr. shuts door on U.S. investment in mRNA vaccine research
Vaccine experts and people steeped in pandemic preparedness expressed horror at the news that RFK Jr. has shut the door in U.S. investment in mRNA vaccine research.
www.statnews.com
August 6, 2025 at 12:36 AM
Horrible decision but sadly par for the course for the HHS secretary.
Reposted by Saheli Sadanand
NEW: Massive and confusing inconsistencies at NIH. New director says health disparities research is critical yet grants are being cut left and right. With @aniloza.bsky.social and @ericboodman.bsky.social. (Also my last story for STAT. 😢) www.statnews.com/2025/08/01/n...
Jay Bhattacharya once studied health disparities. As NIH director, he’s allowed such research to wither
Jay Bhattacharya’s tenure as NIH director has seen health disparities research swept up in the Trump administration’s attack on DEI
www.statnews.com
August 1, 2025 at 11:28 AM
NEW: Massive and confusing inconsistencies at NIH. New director says health disparities research is critical yet grants are being cut left and right. With @aniloza.bsky.social and @ericboodman.bsky.social. (Also my last story for STAT. 😢) www.statnews.com/2025/08/01/n...
Reposted by Saheli Sadanand
Kevin Hall can now speak freely. He's the top nutrition scientist who is clashing with MAHA www.statnews.com/2025/07/30/k... via @statnews.com
Kevin Hall, uncensored: Top nutrition scientist on clashing with MAHA and what he actually eats
'They’re not interested in the science': Former NIH nutrition scientist Kevin Hall on how his work with MAHA fell apart.
www.statnews.com
July 30, 2025 at 3:50 PM
Kevin Hall can now speak freely. He's the top nutrition scientist who is clashing with MAHA www.statnews.com/2025/07/30/k... via @statnews.com