Nature Medicine
@natmed.nature.com
Nature Medicine is a research journal devoted to publishing the latest advances in translational and clinical research for scientists and physicians.
www.nature.com/nm
www.nature.com/nm
Pinned
⚡Our January issue is live! Including the first Nature Medicine Commission Report (introduced in our Editorial), new research on #infertility, #huntingtonsdisease, #cancer #cachexia, #HIV, #genetherapy, #microbiome therapy, News & Opinion and much more
https://www.nature.com/nm/volumes/32/issues/1
https://www.nature.com/nm/volumes/32/issues/1
⚡Our January issue is live! Including the first Nature Medicine Commission Report (introduced in our Editorial), new research on #infertility, #huntingtonsdisease, #cancer #cachexia, #HIV, #genetherapy, #microbiome therapy, News & Opinion and much more
https://www.nature.com/nm/volumes/32/issues/1
https://www.nature.com/nm/volumes/32/issues/1
January 21, 2026 at 4:50 PM
⚡Our January issue is live! Including the first Nature Medicine Commission Report (introduced in our Editorial), new research on #infertility, #huntingtonsdisease, #cancer #cachexia, #HIV, #genetherapy, #microbiome therapy, News & Opinion and much more
https://www.nature.com/nm/volumes/32/issues/1
https://www.nature.com/nm/volumes/32/issues/1
A new trial provides direct human evidence that the #placeboeffect can shape humoral #immunity and vaccine responses, opening new avenues for biomedical research. News & Views from Jonathan Kipnis & colleagues
https://www.nature.com/articles/s41591-025-04168-7
https://www.nature.com/articles/s41591-025-04168-7
Placebo effect influences vaccine responses - Nature Medicine
A randomized trial provides direct human evidence that the placebo effect can shape humoral immunity, showing that reward-related brain activity correlates with vaccine-induced antibody production and opening new avenues for treating many medical conditions.
www.nature.com
January 21, 2026 at 12:01 PM
A new trial provides direct human evidence that the #placeboeffect can shape humoral #immunity and vaccine responses, opening new avenues for biomedical research. News & Views from Jonathan Kipnis & colleagues
https://www.nature.com/articles/s41591-025-04168-7
https://www.nature.com/articles/s41591-025-04168-7
Following the negative phase 3 BRAIN-AF trial with anticoagulant rivaroxaban, Marco Proietti MD PhD and Giulio Francesco Romiti argue that we need to better understand the mechanisms linking #atrialfibrillation and #dementia. Read the News & Views:
https://www.nature.com/articles/s41591-025-04127-2
https://www.nature.com/articles/s41591-025-04127-2
Understanding the link between atrial fibrillation and cognitive decline - Nature Medicine
A phase 3 trial shows no impact of the anticoagulant rivaroxaban on the risk of cognitive decline in individuals with atrial fibrillation and low thromboembolic risk — highlighting the need for a better understanding of the mechanisms that link these conditions.
www.nature.com
January 19, 2026 at 8:01 PM
Following the negative phase 3 BRAIN-AF trial with anticoagulant rivaroxaban, Marco Proietti MD PhD and Giulio Francesco Romiti argue that we need to better understand the mechanisms linking #atrialfibrillation and #dementia. Read the News & Views:
https://www.nature.com/articles/s41591-025-04127-2
https://www.nature.com/articles/s41591-025-04127-2
A randomized trial illustrates the challenges of passive cooling in Africa, where temperatures are rising and millions of new housing units will be needed by the middle of the century. Read the News & Views from Lorenz von Seidlein & colleagues
https://www.nature.com/articles/s41591-025-04155-y
https://www.nature.com/articles/s41591-025-04155-y
Housing modifications for heat adaptation - Nature Medicine
A randomized controlled trial illustrates the challenges of passive cooling in hot humid Africa, where temperatures are rising and millions of new housing units will be needed by the middle of the century.
www.nature.com
January 19, 2026 at 7:00 PM
A randomized trial illustrates the challenges of passive cooling in Africa, where temperatures are rising and millions of new housing units will be needed by the middle of the century. Read the News & Views from Lorenz von Seidlein & colleagues
https://www.nature.com/articles/s41591-025-04155-y
https://www.nature.com/articles/s41591-025-04155-y
In a phase 3 trial, #HIV-negative Vietnamese adults with #TB meningitis were stratified by LTA4H genotype to assess whether this underlies corticosteroid response. The study found outcomes were not significantly better according to genotype. https://www.nature.com/articles/s41591-025-04138-z
January 19, 2026 at 1:01 PM
In a phase 3 trial, #HIV-negative Vietnamese adults with #TB meningitis were stratified by LTA4H genotype to assess whether this underlies corticosteroid response. The study found outcomes were not significantly better according to genotype. https://www.nature.com/articles/s41591-025-04138-z
A Bayesian analysis shows ~2M misdiagnosed with TB (false positives) & 1M false negatives. We need better bacteriological tests! #PublicHealth #WHO
https://www.nature.com/articles/s41591-025-04097-5
https://www.nature.com/articles/s41591-025-04097-5
January 17, 2026 at 8:05 PM
A Bayesian analysis shows ~2M misdiagnosed with TB (false positives) & 1M false negatives. We need better bacteriological tests! #PublicHealth #WHO
https://www.nature.com/articles/s41591-025-04097-5
https://www.nature.com/articles/s41591-025-04097-5
In a phase 2 trial, low-dose interleukin-2 boosted regulatory T cells and reduced arterial inflammation in acute coronary syndrome patients compared to placebo.
https://www.nature.com/articles/s41591-025-04090-y
https://www.nature.com/articles/s41591-025-04090-y
January 17, 2026 at 5:40 PM
In a phase 2 trial, low-dose interleukin-2 boosted regulatory T cells and reduced arterial inflammation in acute coronary syndrome patients compared to placebo.
https://www.nature.com/articles/s41591-025-04090-y
https://www.nature.com/articles/s41591-025-04090-y
This study highlights a dried/capillary blood spot test as a minimally invasive method for #Alzheimer’s #biomarker testing, ideal for resource-limited settings. @wagnersbrum.bsky.social https://www.nature.com/articles/s41591-025-04080-0
January 17, 2026 at 3:30 PM
This study highlights a dried/capillary blood spot test as a minimally invasive method for #Alzheimer’s #biomarker testing, ideal for resource-limited settings. @wagnersbrum.bsky.social https://www.nature.com/articles/s41591-025-04080-0
🧬 New Nature Medicine Comment from Jeffery K. Taubenberger, John H. Powers & Jay Bhattacharya outlines NIAID’s updated research vision, focusing on infectious diseases and immunology.
Read here: https://ow.ly/Ymp550XY6Uy
Read here: https://ow.ly/Ymp550XY6Uy
The new vision from the National Institute of Allergy and Infectious Diseases (NIAID) - Nature Medicine
Preparing for tomorrow’s threats by enhancing our ability to help patients today.
ow.ly
January 16, 2026 at 8:05 PM
🧬 New Nature Medicine Comment from Jeffery K. Taubenberger, John H. Powers & Jay Bhattacharya outlines NIAID’s updated research vision, focusing on infectious diseases and immunology.
Read here: https://ow.ly/Ymp550XY6Uy
Read here: https://ow.ly/Ymp550XY6Uy
#Multiomic single-cell analyses of 15 #DownSyndrome fetal cortical samples identify widespread disruption of neurodevelopmental transcriptional programs, driven by three dosage-sensitive chromosome 21 transcription factors. #Neurodevelopment
https://www.nature.com/articles/s41591-026-04211-1
https://www.nature.com/articles/s41591-026-04211-1
January 16, 2026 at 6:20 PM
#Multiomic single-cell analyses of 15 #DownSyndrome fetal cortical samples identify widespread disruption of neurodevelopmental transcriptional programs, driven by three dosage-sensitive chromosome 21 transcription factors. #Neurodevelopment
https://www.nature.com/articles/s41591-026-04211-1
https://www.nature.com/articles/s41591-026-04211-1
In the phase 1/2 CASTLE basket trial, autologous CD19 CART therapy in patients with treatment-refractory SLE, SSc or IIM was safe with improved disease activity and patient-reported global health in most patients.
https://www.nature.com/articles/s41591-025-04185-6
https://www.nature.com/articles/s41591-025-04185-6
January 16, 2026 at 3:00 PM
In the phase 1/2 CASTLE basket trial, autologous CD19 CART therapy in patients with treatment-refractory SLE, SSc or IIM was safe with improved disease activity and patient-reported global health in most patients.
https://www.nature.com/articles/s41591-025-04185-6
https://www.nature.com/articles/s41591-025-04185-6
In a prespecified secondary analysis of the SURMOUNT-OSA trial it was found that #tirzepatide improves #cardiometabolic outcomes in patients with moderate-to-severe OSA and #obesity.
https://www.nature.com/articles/s41591-025-04071-1
https://www.nature.com/articles/s41591-025-04071-1
January 16, 2026 at 2:40 PM
In a prespecified secondary analysis of the SURMOUNT-OSA trial it was found that #tirzepatide improves #cardiometabolic outcomes in patients with moderate-to-severe OSA and #obesity.
https://www.nature.com/articles/s41591-025-04071-1
https://www.nature.com/articles/s41591-025-04071-1
Long-term follow-up of the FAME 2 trial shows FFR-guided PCI plus medical therapy reduces cardiovascular events vs medical therapy alone.
https://www.nature.com/articles/s41591-025-04132-5
https://www.nature.com/articles/s41591-025-04132-5
January 16, 2026 at 2:02 PM
Long-term follow-up of the FAME 2 trial shows FFR-guided PCI plus medical therapy reduces cardiovascular events vs medical therapy alone.
https://www.nature.com/articles/s41591-025-04132-5
https://www.nature.com/articles/s41591-025-04132-5
Please join our editor Lia Parkin at Keystone Symposia Human Microbiome: From Models and Mechanism to Medicine January 19-22 in Banff! Hope to see you there! https://keysym.us/KSMicrobiome26 #KSMicrobiome26
January 16, 2026 at 1:30 PM
Please join our editor Lia Parkin at Keystone Symposia Human Microbiome: From Models and Mechanism to Medicine January 19-22 in Banff! Hope to see you there! https://keysym.us/KSMicrobiome26 #KSMicrobiome26
A biomarker study in metastatic renal cell carcinoma shows that blood levels of sMAdCAM-1 predict survival in patients on tyrosine kinase and immune checkpoint inhibitors, suggesting a link to gut dysbiosis from three clinical trials. https://www.nature.com/articles/s41591-025-04067-x
January 16, 2026 at 1:00 PM
A biomarker study in metastatic renal cell carcinoma shows that blood levels of sMAdCAM-1 predict survival in patients on tyrosine kinase and immune checkpoint inhibitors, suggesting a link to gut dysbiosis from three clinical trials. https://www.nature.com/articles/s41591-025-04067-x
Genomic and transcriptomic analysis of multiple myeloma samples shows mechanisms of antigen escape from the GPRC5D T cell engager talquetamab, including biallelic deletions, SNVs, insertions-deletions, and chromatin silencing https://www.nature.com/articles/s41591-025-04175-8
January 15, 2026 at 9:26 PM
Genomic and transcriptomic analysis of multiple myeloma samples shows mechanisms of antigen escape from the GPRC5D T cell engager talquetamab, including biallelic deletions, SNVs, insertions-deletions, and chromatin silencing https://www.nature.com/articles/s41591-025-04175-8
Interpersonal conflict & excessive #socialmedia use are linked to increased levels of depression during political protests — but we must not lose sight of the wider contexts in which such protests take place. News & Views from Jon Roozenbeek, Ili Ma
https://www.nature.com/articles/s41591-025-04110-x
https://www.nature.com/articles/s41591-025-04110-x
Political protests, social media use and mental well-being - Nature Medicine
A large, longitudinal study shows that interpersonal conflict and excessive social media use are associated with increased levels of depression during political protests — but we should not lose sight of the wider contexts in which such protests take place.
www.nature.com
January 14, 2026 at 6:30 PM
Interpersonal conflict & excessive #socialmedia use are linked to increased levels of depression during political protests — but we must not lose sight of the wider contexts in which such protests take place. News & Views from Jon Roozenbeek, Ili Ma
https://www.nature.com/articles/s41591-025-04110-x
https://www.nature.com/articles/s41591-025-04110-x
🚨 Worried about infections? Angela Rasmussen explains how removing six vaccines to match Denmark’s schedule risks a measles comeback amid immune amnesia & fragile public health systems. Urgent plea: return to science‑led vaccine policy🧬#VaccinesWork https://ow.ly/8Jkl50XWi9P
January 13, 2026 at 5:49 PM
🚨 Worried about infections? Angela Rasmussen explains how removing six vaccines to match Denmark’s schedule risks a measles comeback amid immune amnesia & fragile public health systems. Urgent plea: return to science‑led vaccine policy🧬#VaccinesWork https://ow.ly/8Jkl50XWi9P
When is yogurt not yogurt?
Moran, Khandpur & Roberto in Nature Medicine propose defining ultra‑processed foods by what they are not to better regulate these products—avoiding loopholes that the food industry exploits.
Read more👉https://ow.ly/Wszx50XTkg4 (Also in STAT News!) #nutrition #foodpolicy
Moran, Khandpur & Roberto in Nature Medicine propose defining ultra‑processed foods by what they are not to better regulate these products—avoiding loopholes that the food industry exploits.
Read more👉https://ow.ly/Wszx50XTkg4 (Also in STAT News!) #nutrition #foodpolicy
Identifying ultra-processed foods for policy - Nature Medicine
Defining non-ultra-processed foods, rather than ultra-processed foods, would better protect the public’s health.
ow.ly
January 13, 2026 at 4:05 PM
When is yogurt not yogurt?
Moran, Khandpur & Roberto in Nature Medicine propose defining ultra‑processed foods by what they are not to better regulate these products—avoiding loopholes that the food industry exploits.
Read more👉https://ow.ly/Wszx50XTkg4 (Also in STAT News!) #nutrition #foodpolicy
Moran, Khandpur & Roberto in Nature Medicine propose defining ultra‑processed foods by what they are not to better regulate these products—avoiding loopholes that the food industry exploits.
Read more👉https://ow.ly/Wszx50XTkg4 (Also in STAT News!) #nutrition #foodpolicy
Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.
https://www.nature.com/articles/s41591-025-04126-3
https://www.nature.com/articles/s41591-025-04126-3
Interpretable inflammation landscape of circulating immune cells - Nature Medicine
Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.
www.nature.com
January 12, 2026 at 3:26 PM
Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.
https://www.nature.com/articles/s41591-025-04126-3
https://www.nature.com/articles/s41591-025-04126-3
🛡️ Comment on “Lessons in public trust” by Heidi Larson (profheidilarson.bsky.social) & Alexander Toledo make a compelling case that strategies used to safeguard vaccine confidence are essential to restoring public faith in organ donation programs.
👉 Full Article: https://ow.ly/IXgn50XSpzQ
👉 Full Article: https://ow.ly/IXgn50XSpzQ
January 6, 2026 at 2:10 PM
🛡️ Comment on “Lessons in public trust” by Heidi Larson (profheidilarson.bsky.social) & Alexander Toledo make a compelling case that strategies used to safeguard vaccine confidence are essential to restoring public faith in organ donation programs.
👉 Full Article: https://ow.ly/IXgn50XSpzQ
👉 Full Article: https://ow.ly/IXgn50XSpzQ
📢 Don’t miss this!
“Eleven clinical trials that will shape medicine in 2026” — FREE to access in Nature Medicine.
See the editors' picks of next-gen vaccines, stem cell therapies and innovative cancer treatments to watch in 2026.
👉 https://ow.ly/ahfu50XLxka
“Eleven clinical trials that will shape medicine in 2026” — FREE to access in Nature Medicine.
See the editors' picks of next-gen vaccines, stem cell therapies and innovative cancer treatments to watch in 2026.
👉 https://ow.ly/ahfu50XLxka
Eleven clinical trials that will shape medicine in 2026 - Nature Medicine
Nature Medicine asks leading researchers to name their top clinical trial for 2026, from long-awaited vaccines for infectious diseases to new treatments for advanced cancers and long COVID.
ow.ly
December 19, 2025 at 3:01 PM
📢 Don’t miss this!
“Eleven clinical trials that will shape medicine in 2026” — FREE to access in Nature Medicine.
See the editors' picks of next-gen vaccines, stem cell therapies and innovative cancer treatments to watch in 2026.
👉 https://ow.ly/ahfu50XLxka
“Eleven clinical trials that will shape medicine in 2026” — FREE to access in Nature Medicine.
See the editors' picks of next-gen vaccines, stem cell therapies and innovative cancer treatments to watch in 2026.
👉 https://ow.ly/ahfu50XLxka
In a year that has dealt many blows to biomedical research, many breakthroughs nevertheless continued to inspire us. Here is our selection of critical developments that moved medicine forward in 2025.
https://www.nature.com/articles/s41591-025-04098-4
https://www.nature.com/articles/s41591-025-04098-4
Notable advances 2025 - Nature Medicine
In a year that has dealt many blows to biomedical research, many breakthroughs nevertheless continued to inspire us. From regenerative medicine to reproductive technologies and everything in between — here is our selection of critical developments that moved medicine forward in 2025.
www.nature.com
December 18, 2025 at 2:02 PM
In a year that has dealt many blows to biomedical research, many breakthroughs nevertheless continued to inspire us. Here is our selection of critical developments that moved medicine forward in 2025.
https://www.nature.com/articles/s41591-025-04098-4
https://www.nature.com/articles/s41591-025-04098-4
⚡Our December issue is live! Check out our Year in Review for 2025 highlights and a what to look out for in 2026; also featuring news, opinioin & new research on #agingclocks, #liquidbiopsies, #Alzheimersdisease, #PCOS, #sepsis, & more.
Read it here: https://www.nature.com/nm/volumes/31/issues/12
Read it here: https://www.nature.com/nm/volumes/31/issues/12
December 18, 2025 at 12:53 PM
⚡Our December issue is live! Check out our Year in Review for 2025 highlights and a what to look out for in 2026; also featuring news, opinioin & new research on #agingclocks, #liquidbiopsies, #Alzheimersdisease, #PCOS, #sepsis, & more.
Read it here: https://www.nature.com/nm/volumes/31/issues/12
Read it here: https://www.nature.com/nm/volumes/31/issues/12
Our latest Review discusses #liquidbiopsy approaches and their clinical validity and utility, highlighting opportunities to support implementation in cancer care. From Valsamo Anagnostou, Victor Velculescu et al. @hopkinsmedicine.bsky.social
https://www.nature.com/articles/s41591-025-04093-9
https://www.nature.com/articles/s41591-025-04093-9
Liquid biopsies across the cancer care continuum - Nature Medicine
This Review summarizes current and emerging liquid biopsy methods, together with their clinical validity and utility, and highlights opportunities to support their implementation throughout the cancer care continuum.
www.nature.com
December 11, 2025 at 1:01 PM
Our latest Review discusses #liquidbiopsy approaches and their clinical validity and utility, highlighting opportunities to support implementation in cancer care. From Valsamo Anagnostou, Victor Velculescu et al. @hopkinsmedicine.bsky.social
https://www.nature.com/articles/s41591-025-04093-9
https://www.nature.com/articles/s41591-025-04093-9