Glucagon-like peptide 1 receptor (GLP1R) agonists like semaglutide drive weight loss through the brain, but insights into their intracellular signaling mechanisms are lacking. Although canonically GLP...

Douglass et al. employ long-term, continuous fiber photometry to uncover new modes of agouti-related peptide (AgRP) neuron regulation in ad libitum, fasted, and circadian conditions. AgRP neuron activity exhibits a circadian rhythm, which controls daily feeding patterns through a neural circuit from the suprachiasmatic nucleus via the dorsomedial hypothalamus.

Ventral striatal dopamine D3 and D1 receptors regulate motivation and reinforcement, respectively, through dissociable physiological actions.

Expanding the bounds of a fear memory or linking it to a neutral memory can shape a mouse’s fear response, two new studies show.

The activation of autonomic and hypothalamo-pituitary-adrenal (HPA) systems occurs interdependently with behavioral adjustments under varying environmental demands. Nevertheless, laboratory rodent stu...