Nature Communications - The oncogenic splicing factor TRA2β is reported to be upregulated in human cancers partly by increased TRA2β poison exon (PE) skipping. Here the authors show that...

Tumor-specific CD8+ T cells are dysfunctional within tumors. Espinosa-Carrasco et al. show that CD4+ T cells must engage with CD8+ T cells on the same antigen-presenting cell (APC) during the effector phase, forming a three-cell-cluster (triad) to license CD8+ T cell cytotoxicity and CD8+ T cell-mediated cancer cell elimination.

Nature - Cell-type-resolved spatial proteomics of the skin from patients with toxic epidermal necrolysis reveals that it is driven by JAK/STAT signaling, leading to successful treatment of this...

Whether PD-1 splicing isoforms impact T cell anti-tumor capacity has not been fully illustrated. Here the authors identify a human PD-1 isoform, PD-1^28, which functions to suppress anti-cancer immuni...

There is growing evidence that full-length mRNAs undergo intercellular transfer through long, thin c