Stefan Isaac
@rsisaac.bsky.social
Assistant Professor at Boston University | mtDNA packaging and regulation | he/him | views are my own | 🏳️🌈
Reposted by Stefan Isaac
I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress
Quantitative imaging of the mitochondrial central dogma identifies translation hubs that are suppressed during stress.
www.science.org
April 18, 2025 at 10:56 PM
I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4
Reposted by Stefan Isaac
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
www.cnn.com
April 9, 2025 at 11:30 AM
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
Reposted by Stefan Isaac
Reposted by Stefan Isaac
Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...
Engineering mtDNA deletions by reconstituting end joining in human mitochondria
Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled precise base substitutions and the efficient elimination of…
www.sciencedirect.com
March 10, 2025 at 6:38 PM
Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...
Reposted by Stefan Isaac
“It’s extremely alarming that grants that have been vetted by the scientific community and deemed important and impactful to understand the world are now being cancelled because of political ideology,” says @lkfazio.bsky.social.
“This is direct censorship of scientific research.”
“This is direct censorship of scientific research.”
Exclusive: NIH to terminate hundreds of active research grants
Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.
www.nature.com
March 6, 2025 at 2:17 AM
“It’s extremely alarming that grants that have been vetted by the scientific community and deemed important and impactful to understand the world are now being cancelled because of political ideology,” says @lkfazio.bsky.social.
“This is direct censorship of scientific research.”
“This is direct censorship of scientific research.”
Everyone should be alarmed by McMahon's "Final Mission" for the DoE: "restoring patriotic education" and aligning education with "workforce needs." On track to completely eliminate critical thinking/intellectual curiosity to focus on nationalist ideology. Among countless other issues.
Secretary McMahon: Our Department's Final Mission
The Department of Education’s role in this new era of accountability is to restore the rightful role of state oversight in education and to end the overreach from Washington.
www.ed.gov
March 5, 2025 at 5:59 PM
Everyone should be alarmed by McMahon's "Final Mission" for the DoE: "restoring patriotic education" and aligning education with "workforce needs." On track to completely eliminate critical thinking/intellectual curiosity to focus on nationalist ideology. Among countless other issues.
Reposted by Stefan Isaac
If you are interested in mitochondria, Nashville is the place to be June 1-5. Check out this FASEB meeting. Please RT. events.faseb.org/event/mitoch...
Mechanisms of Mitochondrial DNA Mutation and Repair
events.faseb.org
March 5, 2025 at 2:32 PM
If you are interested in mitochondria, Nashville is the place to be June 1-5. Check out this FASEB meeting. Please RT. events.faseb.org/event/mitoch...
Reposted by Stefan Isaac
Last weekend I wrote a letter to the editor to my hometown newspaper as part of the Sciencehomecoming.com movement.
I will share my letter in this thread, and share my approach to lower the activation energy for y'all to join me.
🧪 #microsky
I will share my letter in this thread, and share my approach to lower the activation energy for y'all to join me.
🧪 #microsky
Science Homecoming
Sciencehomecoming.com
March 1, 2025 at 4:03 AM
Last weekend I wrote a letter to the editor to my hometown newspaper as part of the Sciencehomecoming.com movement.
I will share my letter in this thread, and share my approach to lower the activation energy for y'all to join me.
🧪 #microsky
I will share my letter in this thread, and share my approach to lower the activation energy for y'all to join me.
🧪 #microsky