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rob
@rrrrrob.bsky.social
51 followers 19 following 5 posts
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Reposted by rob
tomkindlon.bsky.social
Interesting new research from Sweden:

Low Vasopressin In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

www.endocrinepractice.org/article/S153...

Vasopressin or antidiuretic hormone helps the body hold on to fluid

#MEcfs #CFS #PwME #MyalgicEncephalomyelitis #ChronicFatigueSyndrome
orthostatic intolerance and polyuria-polydipsia typify disabling forms of ME/CFS • in a consecutive series of ME-CFS patients, majority had very low vasopressin levels, relatively high plasma osmolality and low urine osmolality, in absence of overt hypothalamic or hypophyseal pathology • chronic down-regulation of vasopressin mimicking central diabetes insipidus may contribute to the core symptoms of ME/CFS ABSTRACT Objective The complex clinical picture of ME/CFS includes orthostatic intolerance with symptoms and signs suggesting abnormal water homeostasis and hypovolemia. Since many ME/CFS patients report polyuria-polydipsia, we conducted an observational study based on series of plasma and urine osmolality (P-Osm and U-Osm) as well as plasma levels of vasopressin (P-VP) or copeptin in consecutive patients diagnosed with ME/CFS according to the International Consensus Criteria. Methods P-VP as well as P-Osm and U-Osm were measured in 111 patients after 10 hour overnight fasting and fluid deprivation. Additional 13 patients were assessed for copeptin, when P-VP measurements were no longer available. The clinical routine also included brain MRI and blood chemistry. Results P-Osm was abnormally high (>292 mOsm/kg) in 71/124 (57.3 %) and U-Osm below the reference interval (< 750 mOsm/kg) in 82/124 (66.1%) patients. P-VP was below the level of detection (<1.6 pg/mL) in 91/111 (82.0 %) patients. A normal P-VP level compared with their P-Osm was found in 11/111 (9.9 %) patients. Copeptin levels were all within the given reference range, albeit in the lower end in most patients. No indication of relevant pathology in either hypothalamus or hypophysis was present. Conclusions Our findings suggest that chronic down-regulation of VP mimicking central diabetes insipidus is an important measurable part of the disease mechanism that potentially contributes to criterial symptoms of ME/CFS.
January 1, 2026 at 1:19 PM
Reposted by rob
postviraltrials.bsky.social
Provides theoretical support for the practice of prescribing desmopressin, which I’ve been on for years, and which has had a successful small RCT for POTS (pubmed.ncbi.nlm.nih.gov/22561596/)
January 1, 2026 at 1:32 PM
Reposted by rob
tomkindlon.bsky.social
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID

onlinelibrary.wiley.com/doi/10.1002/...

"We show for first time widespread abnormalities in the function of unmyelinated somatosensory & autonomic axons that may explain the multiplicity of symptoms in #longCOVID”
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
Objective To review the microneurography findings of long coronavirus disease 2019 (COVID) patients who presented to the clinic with multisystem involvement affecting neurological, cardiovascular, g.....
onlinelibrary.wiley.com
September 28, 2025 at 1:22 PM
Reposted by rob
liapas.bsky.social
Fascinating research on issues with blood flow in the brain in MDD (Major Depressive Disorder). Low blood volume and low blood flow are issues in #MECFS as well.
Functional vs Structural Cortical Deficit Pattern Biomarkers for MDD
This case-control study investigates if a regional homogeneity–magnetic resonance imaging cortical deficit pattern provides a more robust biomarker for major depressive disorder (MDD) than its…
jamanetwork.com
September 24, 2025 at 10:27 PM
Reposted by rob
kgandersen.bsky.social
Imagine that.
roslininstitute.bsky.social The Roslin Institute @roslininstitute.bsky.social · Jul 10
A hybrid coronavirus, formed of cat and dog coronaviruses, caused a severe outbreak of disease among cats in Cyprus, researchers found.

Their work, in Nature, showed how this new virus was able to cause widespread cases of Feline Infectious Peritonitis (FIP) among the island’s cats.
Coronavirus causes fatal disease outbreak in cats | The Roslin Institute | The Royal (Dick) School of Veterinary Studies
A harmful strain of coronavirus has caused a fast-spreading outbreak of a harmful feline disease.
edin.ac
July 11, 2025 at 9:25 AM
Reposted by rob
trishgreenhalgh.bsky.social
New report from UK Healthcare Services Safety Investigations Body (HSSIB): People with long term conditions are being harmed because care is fragmented and care coordinator roles are suboptimal. #healthpolicy #medsky

www.hssib.org.uk/patient-safe...
Workforce and patient safety: primary and community care co-ordination for people with long-term conditions
This is the fourth of five investigation reports that consider how working conditions in the NHS can be optimised to support patient safety, while maintaining and improving staff wellbeing.
www.hssib.org.uk
April 11, 2025 at 6:47 AM
Reposted by rob
postviraltrials.bsky.social
“…we detected anti-ganglioside antibodies (AGAs) in 25% of patients with LC neuropathy, a comparable rate to other AGA-associated neuropathies.” www.medrxiv.org/content/10.1...
Analysis of 977 Long COVID Patients Reveals Prevalent Neuropathy and Association with Anti-Ganglioside Antibodies
Background: Long COVID (LC) is a novel condition that is characterized by persistent symptoms that last from months to years following a SARS-CoV-2 infection. While LC symptoms vary widely, neuropathy...
www.medrxiv.org
March 11, 2025 at 2:10 PM
Reposted by rob
postviraltrials.bsky.social
A phase 2 RCT of plitidepsin for Long Covid has launched at Germans Trias Hospital in Barcelona. They are looking to enroll 90 patients, and the participation criteria are broad clinicaltrials.gov/study/NCT067...
Detailed Description Plitidepsin, a marine-derived cyclic depsipeptide that inhibits SARS-CoV-2 replication at nanomolar concentrations by targeting the host protein eukaryotic translation elongation factor 1A, could be a suitable candidate treatment for "Long COVID" because of a triple mechanism of action; a) it has demonstrated potent anti-SARS-CoV-2 in vitro activity, (b) it has a systemic anti-inflammatory effect, detailed in the text below, and (c) has an anti-herpes antiviral effect, which could provide additional therapeutic benefits to prevent herpesvirus reactivation seen in Long-COVID. Study Contact Name: Lourdes Mateu Pruñonosa, phD, MD Phone Number: +34 93 465 78 97 Email: Imateu@lluita.org Study Contact Backup Name: Cora Loste, phD, MD Phone Number: +34 93 465 78 97 Email: closte@lluita.org
January 30, 2025 at 3:22 PM
Reposted by rob
trishgreenhalgh.bsky.social
If they pull PubMed, do we have a plan B? #academicsky?
January 28, 2025 at 8:51 PM
Reposted by rob
trishgreenhalgh.bsky.social
Oh my goodness. Cochrane behaving badly. Worth doing the long read on this one. #medsky #healthpolicy #medtwitter #episky
January 24, 2025 at 9:22 AM
Reposted by rob
peaseroland.bsky.social
We re-explored key lessons in two specials over Xmas, with @marionkoopmans.bsky.social @virusesimmunity.bsky.social @linseymarr.bsky.social David Hayman and others www.bbc.co.uk/programmes/w...
BBC World Service - Science In Action, Five years of Covid: Part one
Five years on from the emergence of Sars CoV-2, what have we learned?
www.bbc.co.uk
January 23, 2025 at 3:22 PM
Reposted by rob
sunsopeningband.bsky.social
Good to see PEM/PENE finally discussed for what it is—failure of the body’s cells, tissues, and systems to accommodate and recover from loading. A simple, intuitive, and amply support shift in mindset with potentially revolutionary implications for the field.
valebodi.bsky.social valebodi.bsky.social @valebodi.bsky.social · Jan 5
A 2024 #MECFS Year in Review Points to Progress – A Profound Disruption in Energy Production www.healthrising.org/blog/2025/01... In study after study, two themes popped up again & again. Cells across #pwME’s bodies are exhausted & exhibit a “failure to respond” when exposed to stress"
A 2024 ME/CFS Year in Review Points to Progress - and a Profound Disruption in Energy Production - Health Rising
A year in review for chronic fatigue syndrome or ME/CFS findings evidence of cellular exhaustion in many levels caused by mitochondrial dysfunction.
www.healthrising.org
January 5, 2025 at 8:40 PM