Radek Nowak
@rpnowak.bsky.social
Professor @UniBonn. Former @DanaFarber @harvardmed | Targeted Protein Degradation | Chemical and Structural Biology | @UniofOxford alumni. Tweets are my own.
Reposted by Radek Nowak
Congrats to Frontier Medicines on their covalent p53 Y220C activator FMC-220! www.globenewswire.com/news-release...
Frontier Medicines Announces FMC-220, the First Covalent p53 Y220C Activator Development Candidate, with Best-in-Class Potential
FMC-220 is a first-in-class covalent activator of p53Y220C designed to address potency and tolerability challenges of non-covalent approachesIn preclinical...
www.globenewswire.com
January 9, 2025 at 2:13 PM
Congrats to Frontier Medicines on their covalent p53 Y220C activator FMC-220! www.globenewswire.com/news-release...
Exciting science at the Advances in Therapeutic Symposium in Frankfurt! #goTPD #molecularGlues
www.theranova.eu/en/veranstal...
www.theranova.eu/en/veranstal...
Program Advances in Therapeutic Approaches
www.theranova.eu
December 5, 2024 at 1:52 PM
Exciting science at the Advances in Therapeutic Symposium in Frankfurt! #goTPD #molecularGlues
www.theranova.eu/en/veranstal...
www.theranova.eu/en/veranstal...
Reposted by Radek Nowak
So privileged that CHI-Healthtech brought their flagship #DDC conference to Europe, in sunny ☀️ Barcelona! Enjoying tapas and sangria with Heide Düvel @chemb.bsky.social @rpnowak.bsky.social Gopal Sapkota, Ed Tate @nurkocaturk.bsky.social Hannah Peters, Rima Alawar. Thanks for the invitation Tanuja!
December 3, 2024 at 8:48 PM
So privileged that CHI-Healthtech brought their flagship #DDC conference to Europe, in sunny ☀️ Barcelona! Enjoying tapas and sangria with Heide Düvel @chemb.bsky.social @rpnowak.bsky.social Gopal Sapkota, Ed Tate @nurkocaturk.bsky.social Hannah Peters, Rima Alawar. Thanks for the invitation Tanuja!
Reposted by Radek Nowak
Through a series of cryo-EM structures, this study shows how an E2 and ubiquitin itself can play a "structural" role to specify ubiquitin linkage. 🧪
Lovely work by Katrina Warner, @moritzhunkeler.bsky.social @kheewoongbaek.bsky.social, @katherinedonovan.bsky.social and others in the Fischer Lab!
Lovely work by Katrina Warner, @moritzhunkeler.bsky.social @kheewoongbaek.bsky.social, @katherinedonovan.bsky.social and others in the Fischer Lab!
New #preprint - a amazing study of HECT ligase Tom1. This paper is a treat for those of you who LOVE #cryoEM and for those who love #ubiquitin! Congrats to the Fischer lab, including @moritzhunkeler.bsky.social and @ssroyburman.bsky.social who are on #bluesky.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Structural ubiquitin contributes to K48 linkage-specificity of the HECT ligase Tom1
Homologous to E6AP C-Terminus (HECT) ubiquitin ligases play key roles in essential pathways such as DNA repair, cell cycle control or protein quality control. Tom1 is one of five HECT ubiquitin E3 lig...
www.biorxiv.org
November 27, 2024 at 7:37 PM
Through a series of cryo-EM structures, this study shows how an E2 and ubiquitin itself can play a "structural" role to specify ubiquitin linkage. 🧪
Lovely work by Katrina Warner, @moritzhunkeler.bsky.social @kheewoongbaek.bsky.social, @katherinedonovan.bsky.social and others in the Fischer Lab!
Lovely work by Katrina Warner, @moritzhunkeler.bsky.social @kheewoongbaek.bsky.social, @katherinedonovan.bsky.social and others in the Fischer Lab!
Reposted by Radek Nowak
Online! An engineered cereblon optimized for high throughput screening and molecular glue discovery by H. Bailey, J. Eisert, Fiona Sorrell @Fi_in_Frankfurt, Ivan Dikic @iDikic2 et al at @goetheuni @IBC2_GU @MPIBP @merckgroup http://dlvr.it/TGRD4Y
November 27, 2024 at 9:01 PM
Online! An engineered cereblon optimized for high throughput screening and molecular glue discovery by H. Bailey, J. Eisert, Fiona Sorrell @Fi_in_Frankfurt, Ivan Dikic @iDikic2 et al at @goetheuni @IBC2_GU @MPIBP @merckgroup http://dlvr.it/TGRD4Y
Hi BlueSky! Now expanding reach here as well. Go go #ScienceTwitter or should it be #ScienceBlueSky?
November 27, 2024 at 10:10 PM
Hi BlueSky! Now expanding reach here as well. Go go #ScienceTwitter or should it be #ScienceBlueSky?
Was great to contribute to this story together with
JanGerhartz Dominika Pienkowska Ina Dressel & Thomas Geiger from the lab. #CRBN #Interactome #GLUES
authors.elsevier.com/sd/article/S...
Animation credit PROXIDRUGs. Thanks for fantastic colaboration.
JanGerhartz Dominika Pienkowska Ina Dressel & Thomas Geiger from the lab. #CRBN #Interactome #GLUES
authors.elsevier.com/sd/article/S...
Animation credit PROXIDRUGs. Thanks for fantastic colaboration.
November 27, 2024 at 10:06 PM
Was great to contribute to this story together with
JanGerhartz Dominika Pienkowska Ina Dressel & Thomas Geiger from the lab. #CRBN #Interactome #GLUES
authors.elsevier.com/sd/article/S...
Animation credit PROXIDRUGs. Thanks for fantastic colaboration.
JanGerhartz Dominika Pienkowska Ina Dressel & Thomas Geiger from the lab. #CRBN #Interactome #GLUES
authors.elsevier.com/sd/article/S...
Animation credit PROXIDRUGs. Thanks for fantastic colaboration.