@rosellilab.bsky.social
Open position for graduate student at the Roselli lab!
May 23, 2025 at 11:45 AM
Open position for graduate student at the Roselli lab!
To all colleagues here: have you ever built your own hardware upgrades, and is it worth compared to buying it?
May 16, 2025 at 7:05 AM
To all colleagues here: have you ever built your own hardware upgrades, and is it worth compared to buying it?
A new preprint from the lab: are there actionable entry points to treat intracranial hypertension? our investigation of a porcine subdural haematoma model: www.biorxiv.org/content/10.1...
May 8, 2025 at 10:10 PM
A new preprint from the lab: are there actionable entry points to treat intracranial hypertension? our investigation of a porcine subdural haematoma model: www.biorxiv.org/content/10.1...
Reposted
Excited to share our work by exceptional postdoc, Kyungdeok (KD) Kim. 2025 marks 10th anniversary of meningeal lymphatic discovery and I can’t be happier celebrating it with this work addressing how lymphatic dysfunction leads to cognitive deficits ||
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Meningeal lymphatics-microglia axis regulates synaptic physiology
Meningeal lymphatics serve as an outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions. Previo…
www.sciencedirect.com
March 21, 2025 at 3:53 PM
Excited to share our work by exceptional postdoc, Kyungdeok (KD) Kim. 2025 marks 10th anniversary of meningeal lymphatic discovery and I can’t be happier celebrating it with this work addressing how lymphatic dysfunction leads to cognitive deficits ||
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Heading to the Mario Negri Institute in Milan! New TBI research will be presented in our talk there tomorrow!
February 19, 2025 at 12:34 PM
Heading to the Mario Negri Institute in Milan! New TBI research will be presented in our talk there tomorrow!
Reposted
New treatment avenue for #Duchenne muscular dystrophy: researchers found that transcriptional adaptation can boost utrophin production in human cells, unlocking a promising new therapeutic approach!🎉@stainierlab.bsky.social, Lara Falcucci, @cmdooley.bsky.social, @douglasadamoski.bsky.social et al.
Mechanism for treating muscle degeneration discovered
Utrophin increase in muscle cells after transcriptional adaptation normalises cell function in Duchenne muscular dystrophy
www.mpg.de
February 17, 2025 at 10:18 AM
New treatment avenue for #Duchenne muscular dystrophy: researchers found that transcriptional adaptation can boost utrophin production in human cells, unlocking a promising new therapeutic approach!🎉@stainierlab.bsky.social, Lara Falcucci, @cmdooley.bsky.social, @douglasadamoski.bsky.social et al.
Reposted
CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach
https://go.nature.com/42XLYpK
https://go.nature.com/42XLYpK
Woman in cancer remission for record 19 years after CAR-T immune treatment
CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach.
go.nature.com
February 17, 2025 at 5:02 PM
CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach
https://go.nature.com/42XLYpK
https://go.nature.com/42XLYpK
A new collaborative paper is out... a surprising new non-conventional phenotype in ALS, and a way to treat it:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models
In amyotrophic lateral sclerosis, sleep defects occur in patients, risk gene carriers, and mouse models in which they are rescued preclinically by an orexin antagonist.
www.science.org
January 30, 2025 at 11:04 AM
A new collaborative paper is out... a surprising new non-conventional phenotype in ALS, and a way to treat it:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
We are glad to celebrate our associate Florian olde Heuvel, for the award of the Hannelore Kohl Foundation national prize for his work on biomarkers of synaptic damage in human severe TBI ! jnnp.bmj.com/content/95/1...
Dynamics of synaptic damage in severe traumatic brain injury revealed by cerebrospinal fluid SNAP-25 and VILIP-1
Background Biomarkers of neuronal, glial cells and inflammation in traumatic brain injury (TBI) are available but they do not specifically reflect the damage to synapses, which represent the bulk volu...
jnnp.bmj.com
January 24, 2025 at 8:54 AM
We are glad to celebrate our associate Florian olde Heuvel, for the award of the Hannelore Kohl Foundation national prize for his work on biomarkers of synaptic damage in human severe TBI ! jnnp.bmj.com/content/95/1...
Reposted
--- Seminar in #Neuroscience ---
Functional diversity of inhibitory amygdala microcircuits
🗣 Dr. Sabine Krabbe, DZNE, Bonn
📅 Jan 27, 2025 - 16:00
Lecture Hall, Biocenter @unicologne.bsky.social
zoologie.uni-koeln.de/forschung/ne...
@ibehave.bsky.social @ggatto.bsky.social
January 22, 2025 at 8:08 AM
--- Seminar in #Neuroscience ---
Functional diversity of inhibitory amygdala microcircuits
🗣 Dr. Sabine Krabbe, DZNE, Bonn
📅 Jan 27, 2025 - 16:00
Lecture Hall, Biocenter @unicologne.bsky.social
zoologie.uni-koeln.de/forschung/ne...
@ibehave.bsky.social @ggatto.bsky.social
Some more recent work in preprint format (we really like preprinting everything!) : www.biorxiv.org/content/10.1...
Spinal motoneuron excitability is homeostatically-regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice
Homeostatic feedback loops are essential to stabilize the activity of neurons and neuronal networks. It has been hypothesized that, in the context of Amyotrophic Lateral Sclerosis (ALS), an excessive ...
www.biorxiv.org
January 23, 2025 at 11:43 AM
Some more recent work in preprint format (we really like preprinting everything!) : www.biorxiv.org/content/10.1...
A very productive collaboration with the always-great Beato lab! www.cell.com/cell-reports...
Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration
Through in vitro and in vivo electrophysiology and super-resolution microscopy, Nascimento
et al. identify early-stage alterations in pre-motor spinal recurrent inhibition and
monosynaptic Ia excitati...
www.cell.com
January 23, 2025 at 11:41 AM
A very productive collaboration with the always-great Beato lab! www.cell.com/cell-reports...
More neuropathology forays for us, and third paper with the Braaks : actaneurocomms.biomedcentral.com/articles/10....
Patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study - Acta Neuropathologica Communications
Amyotrophic Lateral Sclerosis (ALS) is mainly characterized by the degeneration of corticospinal neurons and spinal α-motoneurons; vulnerable cells display prominent pTDP-43 inclusions. Evidence gathe...
actaneurocomms.biomedcentral.com
January 23, 2025 at 11:39 AM
More neuropathology forays for us, and third paper with the Braaks : actaneurocomms.biomedcentral.com/articles/10....
Forays into human neuropathology and the mistery of white-matter neurons (with the living legends Braak&delTredici): actaneurocomms.biomedcentral.com/articles/10....
Neuropeptide FF (NPFF)-positive nerve cells of the human cerebral cortex and white matter in controls, selected neurodegenerative diseases, and schizophrenia - Acta Neuropathologica Communications
We quantified and determined for the first time the distribution pattern of the neuropeptide NPFF in the human cerebral cortex and subjacent white matter. To do so, we studied n = 9 cases without neur...
actaneurocomms.biomedcentral.com
January 23, 2025 at 11:36 AM
Forays into human neuropathology and the mistery of white-matter neurons (with the living legends Braak&delTredici): actaneurocomms.biomedcentral.com/articles/10....
Highlights from the last three months of RoselliLab work! Marker of synaptic damage and neuroinflammation in human severe TBI pmc.ncbi.nlm.nih.gov/articles/PMC...
Dynamics of synaptic damage in severe traumatic brain injury revealed by cerebrospinal fluid SNAP-25 and VILIP-1
Biomarkers of neuronal, glial cells and inflammation in traumatic brain injury (TBI) are available but they do not specifically reflect the damage to synapses, which represent the bulk volume of the b...
pmc.ncbi.nlm.nih.gov
January 23, 2025 at 11:32 AM
Highlights from the last three months of RoselliLab work! Marker of synaptic damage and neuroinflammation in human severe TBI pmc.ncbi.nlm.nih.gov/articles/PMC...
Blood-CSF barrier in ALS: patterns and alterations across >1000 patients
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
Blood–CSF barrier integrity in amyotrophic lateral sclerosis
The blood–CSF barrier helps to regulate inflammation in the CNS, and to shield the CNS from potentially toxic external factors. Klose et al. show that the
academic.oup.com
January 23, 2025 at 11:28 AM
Blood-CSF barrier in ALS: patterns and alterations across >1000 patients
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
Hypothalamic atrophy as a new imaging endophenotype in ALS: how does it change in ALS variants? www.nature.com/articles/s41...
Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation - Scientific Reports
Scientific Reports - Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation
www.nature.com
January 23, 2025 at 11:26 AM
Hypothalamic atrophy as a new imaging endophenotype in ALS: how does it change in ALS variants? www.nature.com/articles/s41...
A good start into 2025 for the RoselliLab. A refined MR spectroscopy pipeline for the definition of absolute metabolite concentration in the mouse brain with sub-microliter spatial resolution: onlinelibrary.wiley.com/doi/10.1111/...
Sub‐Microliter 1H Magnetic Resonance Spectroscopy for In Vivo High‐Spatial Resolution Metabolite Quantification in the Mouse Brain
An optimized acquisition and post-processing pipeline for brain magnetic resonance spectroscopy based on the LASER sequence is reported, enabling metabolite spectra from 700 nL volume of interest in ...
onlinelibrary.wiley.com
January 23, 2025 at 11:24 AM
A good start into 2025 for the RoselliLab. A refined MR spectroscopy pipeline for the definition of absolute metabolite concentration in the mouse brain with sub-microliter spatial resolution: onlinelibrary.wiley.com/doi/10.1111/...
Here comes the RoselliLab also on BlueSky !
January 23, 2025 at 11:21 AM
Here comes the RoselliLab also on BlueSky !