@roman-melnyk.bsky.social
Excited to be a part of this important work. Congrats to everyone involved! www.nature.com/articles/s41...
Atomically accurate de novo design of antibodies with RFdiffusion - Nature
The combination of computational design, laboratory-based screening and biophysical validation enables the de novo generation of variable heavy-chain antibody fragments and antibodies that precis...
www.nature.com
November 20, 2025 at 2:14 PM
Excited to be a part of this important work. Congrats to everyone involved! www.nature.com/articles/s41...
Reposted
Really fun collaboration with Roman Melnyk from The Hospital for Sick Children Research Institute and Peter Dosa from University of Minnesota, making synthetic bile acids to be gut-restricted prevents C. difficile infection in a preclinical mouse model
#NewResearch
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
www.nature.com
November 18, 2025 at 2:26 PM
Really fun collaboration with Roman Melnyk from The Hospital for Sick Children Research Institute and Peter Dosa from University of Minnesota, making synthetic bile acids to be gut-restricted prevents C. difficile infection in a preclinical mouse model